Pure Lidocaine Powder

Lidocaine 

Pure Lidocaine powder is a type of local anesthetic that is commonly used to relieve pain, itching, and discomfort caused by various medical procedures such as injections, minor surgeries, laser treatments, and dental procedures. It works by blocking the nerve signals in the affected area, numbing the area, and reducing discomfort.

In addition to its use in medical settings, lidocaine is also sometimes used for non-medical purposes. Some people use it as a topical numbing agent or to relieve pain associated with conditions such as arthritis, sciatica, and shingles. Lidocaine can also be used recreationally and is sometimes abused as a drug due to its numbing effects, which can produce a temporary high or numbness.

However, it's important to note that the use of lidocaine without proper medical supervision can be dangerous and even life-threatening. Overuse or misuse of lidocaine can lead to serious side effects such as seizures, heart problems, and respiratory distress. Therefore, it's recommended that lidocaine only be used with proper medical guidance and supervision.

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Where To Buy Lidocaine
Xi'an Sonwu Biotech Co. Ltd. has rich experience in the global trade and health industry. Insisting on faith-based and quality first is our company’s principle. We strictly control product quality, which means selection starts from raw materials. Besides, we handle every detail and reduce the cost to the maximum extent, then our customers can get cost-effective products. Based on these, customers have given much good feedback to our products. So you can look for Xi'an Sonwu Biotech Co. Ltd. when you want to buy Lidocaine.

Xi'an Sonwu completely makes sure of the product’s quality, so samples can be supplied. Here is the quantity.

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Mechanism Of Action

Lidocaine is a local anesthetic of the amide-type. It is used to provide local anesthesia by nerve blockade at various sites in the body. It does so by stabilizing the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby affecting local anesthetic action. In particular, the lidocaine agent acts on sodium ion channels located on the internal surface of nerve cell membranes. At these channels, neutral uncharged lidocaine molecules diffuse through neural sheaths into the axoplasm where they are subsequently ionized by joining with hydrogen ions. The resultant lidocaine cations are then capable of reversibly binding the sodium channels from the inside, keeping them locked in an open state that prevents nerve depolarization. As a result, with sufficient blockage, the membrane of the postsynaptic neuron will ultimately not depolarize and will thus fail to transmit an action potential. This facilitates an anesthetic effect by not merely preventing pain signals from propagating to the brain but by aborting their generation in the first place.

In addition to blocking conduction in nerve axons in the peripheral nervous system, lidocaine has important effects on the central nervous system and cardiovascular system. After absorption, lidocaine may cause stimulation of the CNS followed by depression, and in the cardiovascular system, it acts primarily on the myocardium where it may produce decreases in electrical excitability, conduction rate, and force of contraction.

Medical Uses Of The Lidocaine

Lidocaine is a local anesthetic medication that is used for various medical purposes.

Pain relief:

Lidocaine has the effect of pain relief. It is a local anesthetic that works by blocking nerve signals in the body, which helps to reduce the sensation of pain and discomfort. Lidocaine can be administered through injection, topical application, or as a patch to provide pain relief.

Arrhythmia treatment:

Lidocaine can also be used to treat certain types of irregular heartbeat (arrhythmias). Lidocaine is a class I antiarrhythmic medication, which means it works by blocking sodium channels in the heart. By blocking these channels, Lidocaine helps to stabilize the heart's electrical activity and prevent certain types of irregular heartbeat (arrhythmias), particularly ventricular arrhythmias.

Lidocaine is usually administered intravenously (IV) in a hospital or clinical setting to treat ventricular arrhythmias, including ventricular tachycardia and ventricular fibrillation. These arrhythmias can be life-threatening, and Lidocaine can quickly restore normal heart rhythm and prevent further complications.

It is important to note that Lidocaine is not effective for all types of arrhythmias and should only be used under the guidance of a healthcare professional. Lidocaine can also cause serious side effects if not dosed correctly, so it is important to carefully monitor patients who are receiving this medication.

Before using Lidocaine to treat arrhythmias, your doctor will perform a thorough evaluation and may use other medications or treatments first, depending on the type and severity of the arrhythmia.

Topical anesthesia:

The efficacy profile of lidocaine as a local anesthetic is characterized by a rapid onset of action and intermediate duration of efficacy. Therefore, lidocaine is suitable for infiltration, block, and surface anesthesia. Longer-acting substances such as bupivacaine are sometimes given preference for spinal and epidural anesthesias; lidocaine, though, has the advantage of a rapid onset of action. Adrenaline vasoconstricts arteries, reducing bleeding and also delaying the resorption of lidocaine, almost doubling the duration of anesthesia.

Lidocaine can be applied topically in the form of gels, sprays, creams, or patches to numb the skin surface. This can make it useful for minor skin procedures like dermal fillers and laser resurfacing.

Dental procedures:

Lidocaine is one of the most commonly used local anesthetics in dentistry. It can be administered in multiple ways, most often as a nerve block or infiltration, depending on the type of treatment carried out and the area of the mouth worked on. Pure Lidocaine Powder is often used by dentists to numb the gums and teeth during procedures like root canal treatment, tooth extraction, and other oral surgeries.

Spinal anesthesia:

Lidocaine can also be used for spinal anesthesia. A small amount of the drug is injected into the spinal fluid, which numbs the lower half of the body, enabling pain-free surgical procedures.

Overall, lidocaine is a versatile medication that can be used for a variety of medical purposes. However, it should only be used under the guidance of a trained healthcare professional due to its potential side effects and risk of toxicity if not dosed correctly.

Absorption

In general, lidocaine is readily absorbed across mucous membranes and damaged skin but poorly through intact skin. The agent is quickly absorbed from the upper airway, tracheobronchial tree, and alveoli into the bloodstream. And although lidocaine is also well absorbed across the gastrointestinal tract the oral bioavailability is only about 35% as a result of a high degree of first-pass metabolism. After injection into tissues, lidocaine is also rapidly absorbed and the absorption rate is affected by both vascularity and the presence of tissue and fat capable of binding lidocaine in the particular tissues.

The concentration of lidocaine in the blood is subsequently affected by a variety of aspects, including its rate of absorption from the site of injection, the rate of tissue distribution, and the rate of metabolism and excretion. Subsequently, the systemic absorption of lidocaine is determined by the site of injection, the dosage given, and its pharmacological profile. The maximum blood concentration occurs following intercostal nerve blockade followed in order of decreasing concentration, the lumbar epidural space, brachial plexus site, and subcutaneous tissue. The total dose injected regardless of the site is the primary determinant of the absorption rate and blood levels achieved. There is a linear relationship between the amount of lidocaine injected and the resultant peak anesthetic blood levels.

Nevertheless, it has been observed that lidocaine hydrochloride is completely absorbed following parenteral administration, its rate of absorption depends also on lipid solubility and the presence or absence of a vasoconstrictor agent. Except for intravascular administration, the highest blood levels are obtained following intercostal nerve block and the lowest after subcutaneous administration.

Additionally, lidocaine crosses the blood-brain and placental barriers, presumably by passive diffusion.

Protein Binding

The protein binding recorded for lidocaine is about 60 to 80% and is dependent upon the plasma concentration of alpha-1-acid glycoprotein. Such percentage protein binding bestows lidocaine with a medium duration of action when placed in comparison to other local anesthetic agents.

Metabolism

Lidocaine is metabolized predominantly and rapidly by the liver, and metabolites and unchanged drugs are excreted by the kidneys. Biotransformation includes oxidative N-dealkylation, ring hydroxylation, cleavage of the amide linkage, and conjugation. N-dealkylation, a major pathway of biotransformation, yields the metabolites monoethylglycinexylidide and glycinexylidide. The pharmacological/toxicological actions of these metabolites are similar to but less potent than, those of lidocaine HCl. Approximately 90% of lidocaine HCl administered is excreted in the form of various metabolites, and less than 10% is excreted unchanged. The primary metabolite in urine is a conjugate of 4-hydroxy-2,6-dimethylaniline.

What Other Drugs Will Affect Lidocaine

Tell your doctor about all your other medicines, especially:

cimetidine, fluvoxamine, nefazodone, St John's wort;

antibiotic or antifungal medicine;

antiviral medicine to treat hepatitis or HIV/AIDS;

heart or blood pressure medicine--amiodarone, digoxin, nicardipine, procainamide, propranolol;

seizure medicine--carbamazepine, phenytoin; or

tuberculosis medicine--isoniazid, rifampin.

This list is not complete. Other drugs may affect lidocaine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

The Side Effects Of Topical Lidocaine

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.

The side effects below only apply to lidocaine 5% ointment and LiDORx (lidocaine) 3% gel:

Blood problems (methemoglobinemia): Seizures, loss of consciousness, fast heart beat, trouble breathing, feeling dizzy or faint, feeling tired, skin color turning blue

Too much lidocaine in your body: Drowsiness, confusion, slow heart beat, trouble breathing, difficulty controlling muscle movements

Serious allergic reactions: Swelling of the face, difficulty breathing, trouble speaking, throat tightening up, red and itchy rash, lightheadedness, clammy skin

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

The side effects below only apply to lidocaine 5% ointment and LiDORx (lidocaine) 3% gel:

Lightheadedness

Dizziness

Feeling sleepy and tired

Ringing in the ears

Blurry or double vision

Vomiting

Feeling hot, cold, or numb

Twitching, shaking

Seizures

Coma

Trouble breathing

Slow heart rate

Low blood pressure

Other Side Effects

The side effects below only apply to lidocaine 5% ointment and LiDORx (lidocaine) 3% gel:

Nervousness

Overwhelming feeling of happiness and joy

Feeling confused

Pharmacist Tips For Topical Lidocaine

1. Always wash your hands after applying topical lidocaine. Otherwise, leftover lidocaine on your hands can cause very bothersome irritation if it accidentally gets on sensitive areas of the skin, such as your eyes.

2. Avoid applying topical lidocaine to large areas of your skin, especially if you have blisters or open wounds. This can cause your skin to absorb more medication and lead to serious side effects.

3. If you're using the lidocaine 5% cream for hemorrhoids, only apply the medication to the irritated skin outside the anus. Don't use your finger or applicators to insert the cream inside the anus.

4. Make sure to shake the container before using the lidocaine spray and the lidocaine foaming soap.

5. Talk with your healthcare provider if your pain lasts more than 7 days, if your condition doesn't get better, or if your symptoms return after getting better.

6. It's not recommended to use more than one medication that contains lidocaine at the same time. Doing so can lead to skin irritations or more serious side effects, such as seizures, heart rhythm problems, and coma. Topical lidocaine can be found in many over-the-counter pain medications that you apply to your skin. These include pain patches, soaps, gels, and creams. Talk with your pharmacist or healthcare provider if you're not sure whether you're using multiple topical lidocaine products.

How Long Does Topical Lidocaine Take To Work

How long it takes for topical lidocaine to relieve pain can differ depending on what kind of product you use (e.g., cream, ointment, or gel) and where you apply the medication. A couple of studies looking at how well a particular lidocaine 4% gel worked in easing pain from cosmetic skin procedures showed that many people experienced pain relief in about 25 to 40 minutes.

Factory

1. Xi'an Sonwu Biotech Co., Ltd has its own factory, so it has adequate stock. Also, Xi'an Sonwu has a clean and tidy production department with advanced equipment. With the lead of Xi'an Sonwu, researchers are constantly developing new products to meet customers' needs.

2. Xi'an Sonwu Biotech Co., Ltd has advanced test equipment and professional testers, which all show that Xi'an Sonwu aims to supply accurate and effective data and good service.

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Logistics Update

In addition to guaranteeing product quality, the other most vital thing is clients could receive the goods smoothly. So, Xi’an Sonwu supplies all kinds of couriers according to different needs.

Company's Profile
Xi'an Sonwu Biotech Co., Ltd is a professional Chinese manufacturer and products supplier. It was founded in 2012 and is located in the Hi-Tech Industrial Zone, Xi'an City, Shannxi Province, China. lt pays all attention to the development, research, and production of food additives, plants, extract, APl, and other ingredients of health care products. The company supplies five kinds of raw material products: Anti-hair loss Powders, Nootropic, API, Muscle Building products， and Plant Extract. Xi'an Sonwu sincerely believes that the premise of great cooperation is the best service and good quality. So, welcome your inquiry.

And if you want to know the Pure Lidocaine powder price, please contact XI’an Sonwu Biotech Co., Ltd.
Email: sales@sonwu.com

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