Spermidine Trihydrochloride

Product's Description

Spermidine Trihydrochloride has been a popular substance in anti-aging research, which is a natural polyamine that stimulates cytoprotective macrophagy/autophagy. Actually, spermidine is naturally occuring in human body, but as aging, the level of spermidine is decreasinbg gradually. Thefore, in vitro spermidine supplementation is extremely important. Increasing the intake of polyamines can increase the content of endogenous polyamines in the body, and can alleviate cardiovascular and other diseases caused by aging by inducing autophagy, thereby exerting anti-aging and life-extending effects. Because of its good effect, there are more and more spermidine suppliers on the market. As one of suppliers, Xi'an Sonwu Biotech can supply high quality products. And Xi'an Sonwu has received much good comments about spermidine. If you want to know more about it, welcome your enquiry.

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Mechanism

Although aging is inevitable, it can be modified by biological and genetic interventions, pharmaceuticals, lifestyle, and environment. Spermidine has been proved to be very vital for prolonging life. And there are many reports proving that abnormal changes in spermidine content are associated with aging as well as disease development. Spermidine is an inducer of autophagy, which is the main mechanism of anti-aging.

Firstly, spermidine triggers autophagy by regulating the expressions of Atg genes. Secondly, it adjusts transcription factor elF5A which can accelerate the synthesis of transcription factor TFEB. Thirdly, spermidine inhibits EP300, which directly stimulates the acetylation of Atg genes and indirectly promotes deacetylation of tubulin due to inhibition of aTAT1.

Besides, spermidine plays a potent anti-inflammatory roles by inhibiting of all kinds of inflammatory cytokines, like ROS, NF-κB, IL-1β and IL-18. Wht's more, it participates in the regulation of cell proliferation, differentiation, senescence, apoptosis and necrosis, eventually stimulates cell growth and inhibiting cell death. Being an anti-aging agent, spermidine suppresses histone acetylation.In addition, spermidine modulates lipid metabolism. First, it accelerates the differentiation of preadipocytes into mature adipocytes. Then, it chanes lipid profile, regulates lipogenic gene expressions, and inhibits lipid accumulation.

Function

1. Enhance cognitive function

Increased intake of spermidine probably decline the risk of many age-related diseases like metabolic disease, heart disease and neurodegeneration. What's more, it can improve cognition ability and memory. Spermidine has a neuroprotective effect against neuron damage caused by inflammation and ischemia. Why it can does this? It can dissolve amyloid-beta proteins through autophagy, which is greatly helpful to prevent memory loss in older people suffering from dementia. Besides, spermidine can protect DNA from damage caused by oxidative stress. It can stabilise mitochondrial DNA, thus preventing aging caused by mutations of mitochondrial genome. Both genomic instability and telomere shortening are signatures of aging. There are nine signatures for measuring the changes that occur within organisms as they age. Spermidine can inhibit five of the nine hallmarks of aging.

2. Anti-aging

Spermidine Trihydrochloride has good effects of fading signs of aging that occur on physical part.The most obvious signs of aging can be found on our face, such as, fine lines, deep wrinkles and sagging skin. However, they are seemingly inevitable in the aging process, which makes people feel scaried but pushes the development of the skincare and antiaging industries. Spermidine helps peolpe a lot. Spermidine supplements is the combination of spermidine and the active ingredients of wheat germ, which can produce keratin to decrease deep wrinkles and promote hair growth, longer lashes and stronger nails. Som studies has shown that spermidine secretions from the streptococcus bacteria that lives in the skin biome stimulate production of collagen, elastin and lipids in older skin cells. This ameliorate skin structure and barrier function.

3. Improve immunity

In past years, becaus of COVID-19 pandemic, human's longevity and health have been influenced a lot. As governments scrambled to control coronavirus, research turned to delve into potential therapeutics to treat its symptoms. Actually, There are several studies which have investigated the influence of spermidine on immune health. During the pandemic, to be against cornavirus, people want to improve immunity and decrease inflammation by using some supplements, which is helpful to prevent and reduce symptoms of the cold and flu. And spermidine supplement is a popular one, because it works by autophagy, which is part of the immune system clearing away pathogens and regulating inflammation. So this hypothesis is not so far-fetched.

It is obvious that most victims are the old, because of their hypoimmunity. So the point of this research is whether spermidine could improce the old's immunity. It is observed that the content of spermidine taking part in immune response in human T cells decreases with aging. By taking in spermidine supplements, spermidine level increases and then autophagy function is improved, which brings in better immunity for people.

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FAQ

1. What is the recommended dosage?

No matter what kind of supplement you take , be sure the limited dosage of pure spermidine a day is 12mg.

2. What matter needs attention?

The wheat germ extract rich in spermidine consists of allergen, such as, gluten and wheat. If you are allergic to them, please take it with much caution. And maybe, a pure synthetic spermidine will be acceptable.

If you have interest and want to buy Spermidine Trihydrochloride, please contact us directly.

Email: sales05@sonwu.com

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