Domperidone Powder

Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of domperidone powder in China. We warmly welcome yuo to wholesale bulk domperidone powder for sale here from our factory. Quality products and reasonable price are available.

Domperidone

Domperidone Powder is an antiemetic (anti-sickness) and prokinetic drug. It belongs to a group of drugs called dopamine antagonists. It is used to treat stomach-related issues, such as nausea and vomiting, as well as stomach pain and discomfort caused by decreased movement of the stomach and upper gastrointestinal (GI) tract. It is also used to boost breastmilk supply. Domperidone works to boost breastmilk supply by increasing the level of a hormone called prolactin, which stimulates the production of breastmilk.

Domperidone works by blocking dopamine receptors in the gut. It increases the movement or contractions of the muscles in your stomach and intestines, increasing how quickly and easily food moves through your digestive tract. It also acts on the chemoreceptor trigger zone in your brain, which is involved in nausea and vomiting. This area of your brain is outside the blood-brain barrier. Unlike other dopamine antagonists, domperidone does not cross the blood-brain barrier, which minimizes central nervous system (CNS) side effects.

Domperidone is available on prescription and in some places as an over-the-counter (OTC) medicine. It is available in many places around the world, including the UK, Europe, Canada,  and New Zealand. Approved uses of the drug vary from country to country. It is also used for off-label or unapproved conditions, including boosting breastmilk supply.

Domperidone is used in several countries for the treatment of disorders such as gastric epilation disorders, functional gastroenterology, and reflux esophagitis, and is widely used in clinical fields such as gastroenterology, pediatrics, and neurology. However, it should also be noted that Domperidone should be used with caution, as it may cause adverse effects such as heart problems. When using this medicine, people should follow the advice of their doctor and follow the correct method and dosage.

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Where To Buy Domperidone

Xi'an Sonwu Biotech Co. Ltd. has rich experience in the global trade and health industry. Insisting on faith-based and quality first is our company’s principle. We strictly control product quality, which means selection starts from raw materials. Besides, we handle every detail and reduce the cost to the maximum extent, then our customers can get cost-effective products. Based on these, customers have given much good feedback to our products. So you can look for Xi'an Sonwu Biotech Co. Ltd. when you want to buy Domperidone.

Xi'an Sonwu completely makes sure of the product’s quality, so samples can be supplied. Here is the quantity.

Customers’s Good Comment

OEM Service

Xi'an Sonwu not only can supply high-quality Domperidone powder but also supply Domperidone capsules.

So any customers could customize the capsules they want. And items below can be supplied.

1. Customized capsules shells (size, color, material)

2. Customized bottles(size, color, material, style)

3. Customized packaging(vacuum foil packaging, box, drum)

4. Customized label(paint film, matte film, optical mask)

The Mode Of Action Of Domperidone

The mode of action of domperidone is through its selective blockade of dopamine receptors in the brain and gastrointestinal tract. Domperidone acts as a dopamine antagonist, which means it binds to dopamine receptors without activating them. This leads to an increase in the release of acetylcholine, a neurotransmitter that enhances the motility of the digestive system. By increasing the muscle contractions of the stomach and intestinal wall, domperidone helps food pass through the digestive system more quickly and efficiently, reducing symptoms such as nausea, vomiting, and bloating.

Domperidone also inhibits the release of prolactin, a hormone that stimulates breast milk production, which makes it useful in treating certain lactation disorders. Overall, the mode of action of domperidone is to enhance gastrointestinal motility, reduce symptoms, and promote digestive health.

The Differences Between Domperidone And Metoclopramide

Domperidone and metoclopramide are both prokinetic medications used to treat gastrointestinal disorders and related symptoms, but they have some differences in their mode of action, indications, side effects, and dosage.

Mode of action: Domperidone acts as a dopamine antagonist, while metoclopramide acts as a dopamine receptor antagonist and a serotonin receptor agonist. Metoclopramide also blocks the action of certain neurotransmitters in the brain, which can lead to a range of side effects.

Indications: Domperidone is primarily used to treat gastric motility disorders such as delayed gastric emptying, functional dyspepsia, and gastroesophageal reflux disease (GERD). In contrast, metoclopramide is used to treat a wider range of conditions, including nausea and vomiting caused by chemotherapy or surgery, gastroparesis, and migraines.

Side effects: Domperidone is generally well-tolerated with few side effects, while metoclopramide has a higher incidence of adverse reactions such as drowsiness, restlessness, dystonia, and tardive dyskinesia.

Dosage: The recommended dose of domperidone is usually lower than that of metoclopramide, and it should not be used in patients with severe liver or kidney disease.

In summary, while both domperidone and metoclopramide are effective prokinetic agents, they differ in their mechanism of action, indications, side effects, and dosage. Patients should consult with their doctor to determine which medication is most appropriate for their individual needs.

Applications

1. Nausea and vomiting

There is some evidence that domperidone has antiemetic activity. It is recommended in the Canadian Headache Society's guidelines for the treatment of nausea associated with acute migraine.

2. Gastroparesis

Gastroparesis is a medical condition characterized by delayed emptying of the stomach when there is no mechanical gastric outlet obstruction. Its cause is most commonly idiopathic, a diabetic complication, or a result of abdominal surgery. The condition causes nausea, vomiting, fullness after eating, early satiety (feeling full before the meal is finished), abdominal pain, and bloating. Domperidone may be useful in diabetic and idiopathic gastroparesis. However, the increased rate of gastric emptying induced by drugs like domperidone does not always correlate (equate) well with the relief of symptoms.

3. Parkinson's disease

Parkinson's disease is a chronic neurological condition where a decrease in dopamine in the brain leads to rigidity (stiffness of movement), tremors, and other symptoms and signs. Poor gastrointestinal function, nausea, and vomiting are major problems for people with Parkinson's disease because most medications used to treat Parkinson's disease are given by mouth. These medications, such as levodopa can cause nausea as a side effect. Furthermore, anti-nausea drugs, such as metoclopramide, which do cross the blood-brain barrier may worsen the extra-pyramidal symptoms of Parkinson's disease.

Domperidone can be used to relieve gastrointestinal symptoms in Parkinson's disease, because, even though it blocks dopamine receptors (which would be expected to worsen Parkinson's disease), it does not cross the blood-brain barrier (the barrier between the blood circulation of the brain and the rest of the body).In addition to this, domperidone may enhance the bioavailability (effect) of levodopa (one of the main treatments for Parkinson's disease). Although these features make domperidone a useful drug in Parkinson's disease, caution is needed due to the cardiotoxic side effects of domperidone especially when given intravenously, in elderly people, and in high doses (> 30 mg per day). A clinical sign of domperidone's potential toxicity to the heart is the prolongation (lengthening) of the QT interval (a segment of the heart's electrical pattern).

Key Facts

You can take Domperidone when you need it, up to 3 times a day.

Domperidone should start to work in about 30 to 60 minutes.

It works best if you take it before meals.

The most common side effect of domperidone is a dry mouth, but this is usually mild and goes away by itself.

Domperidone is usually only prescribed for a short time (up to 1 week).

Who Can Take Domperidone

Most adults, and children aged 12 years old and over, can take domperidone.

It's sometimes prescribed for babies and younger children by a specialist doctor.

Who May Not Be Able To Take Domperidone

Domperidone is not suitable for some people. To make sure it's safe for you, tell your doctor or pharmacist before taking this medicine if you:
have ever had an allergic reaction to Domperidone or any other medicine
weigh less than 35kg
have a condition that can cause a blockage in your bowel, such as Crohn's disease or diverticulitis
have recently had abdominal surgery, such as a hernia operation or cesarean section
have ever had to bleed from your stomach or gut
have a tumor on your pituitary gland
have liver, kidney, or heart problems, or an irregular heartbeat (arrhythmia)
Domperidone may not be suitable for people over 60 years old. This is because there's more risk of side effects.

How And When To Take Domperidone

Always follow a doctor's instructions when taking Domperidone.

1. How to take it
Swallow your tablet whole with a drink of water. Do not crush or chew it.
Domperidone liquid comes with an oral plastic syringe to help you measure your dose. If you do not have a syringe, ask a pharmacist for one. Do not use a kitchen teaspoon, as this will not measure the right amount.
You can take Domperidone up to 3 times a day, but only take it when you need it. Leave 8 hours between each dose you take.
It's best to take Domperidone before food. Take it 15 to 30 minutes before you have a meal or snack.

2. How long to take it for
You'll usually take Domperidone for up to 1 week. This is because it can cause an irregular heartbeat (arrhythmia) if you take it for longer or at a high dose.
Your doctor will tell you how long to take it. They'll recommend that you take it for the shortest possible time and at the lowest dose that works for you.

3. If you forget to take it

If you forget to take domperidone, take it as soon as you remember, as long as this is at least 2 hours before your next dose is due. If it is less than 2 hours before your next dose is due, skip the missed dose and take the next one at the usual time.

Never take 2 doses at the same time. Do not take a double dose to make up for a forgotten dose.

4. If you take too much

Taking too much Domperidone can be dangerous.
If you take more than your prescribed dose, you may get a fast or irregular heartbeat.
If you need to go to A&E, do not drive yourself. Get someone else to drive you or call for an ambulance.
Take the Domperidone packet, or the leaflet inside it, plus any remaining medicine with you.

The Side Effects Of Domperidone

Domperidone can cause serious side effects. Stop taking domperidone and see your doctor or go to a hospital straightaway if:

You get swelling of the hands, feet, ankles, face, lips, or throat which may cause difficulty in swallowing or breathing. You may also notice an itchy, lumpy rash (hives) or nettle rash (urticaria). This may mean you are having an allergic reaction to this medicine.

You notice any uncontrolled movements. These include irregular eye movements, unusual movements of the tongue, and abnormal posture such as a twisted neck, trembling, and muscle stiffness. This is more likely to happen in children. These symptoms should stop once you stop taking this medicine.

1. Common side effects of domperidone include:

Dry mouth

2. Uncommon side effects of domperidone include:

Lowering of sexual drive (libido) in men

Feeling anxious

Feeling drowsy

Headaches

Diarrhea

Itchy skin. You may also have a rash

Unusual production of breast milk in men and women

Painful or tender breasts

A general feeling of weakness

3. Other side effects (frequency unknown) of domperidone include:

Disorders of the cardiovascular system: heart rhythm disorders (rapid or irregular heartbeat) have been reported; if this happens, you should stop the treatment immediately. Domperidone may be associated with an increased risk of heart rhythm disorder and cardiac arrest. This risk may be more likely in those over 60 years old or taking doses higher than 30 mg per day.

Feeling agitated or irritable

Feeling more nervous than usual

Abnormal eye movements

Inability to urinate

Breast enlargement in men

In women, menstrual periods may be irregular or stop
A blood test shows changes in the way your liver is working

Some patients who have used this medicine for conditions and dosages requiring longer-term medical supervision have experienced the following unwanted effects:

Restlessness; swollen or enlarged breasts, unusual discharge from breasts, irregular menstrual periods in women, difficulty breastfeeding, depression, hypersensitivity.
Side effects such as feeling drowsy, nervous, agitated or irritable, or having a fit are more likely to happen in children.
These are not all of the possible side effects of domperidone. Call your doctor for medical advice about side effects.

Interactions

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Do not take domperidone if you are taking medicine to treat:

Fungal infections such as azole anti-fungals, specifically oral ketoconazole, fluconazole or voriconazole.

Bacterial infections, specifically erythromycin, clarithromycin, telithromycin, moxifloxacin, and pentamidine (these are antibiotics)
Heart problems or high blood pressure (amiodarone, dronedarone, quinidine, disopyramide, dofetilide, sotalol, diltiazem, verapamil)

Psychoses (haloperidol, pimozide, sertindole)

Depression (citalopram, escitalopram)

Gastro-intestinal disorders (cisapride, dolasetron, prucalopride)

Allergy (mequitazine, mizolastine)

Malaria (in particular halofantrine)

AIDS/HIV (protease inhibitors)

Cancer (toremifene, vandetanib, vincamine)

Tell your doctor or pharmacist if you are taking drugs to treat infection, heart problems, or AIDS/HIV.
Talk to your doctor if you need to take domperidone and apomorphine. Before you use these two medicines together your doctor will ensure that you can tolerate both when used simultaneously. Ask your doctor or specialist for advice.
It is important to ask your doctor or pharmacist if domperidone is safe for you when you are taking any other medicines, including medicines obtained without a prescription.

Pregnancy And Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed.

Domperidone is not usually recommended in pregnancy. There is limited information available about the use of this medicine in pregnant people. Domperidone should only be used during pregnancy when justified by the anticipated therapeutic benefit. Ask your doctor for advice before taking this medicine.

Domperidone is not usually recommended if you are breastfeeding. Small amounts of this medicine have been detected in breastmilk. It may cause unwanted side effects affecting the heart in a breastfed baby. Domperidone should be used during breastfeeding only if your doctor considers this clearly necessary. Ask your doctor for advice before taking this medicine.

The Ingredients In Domperidone

Active ingredient:

Domperidone
Inactive ingredients:
Motilium tablets: lactose maize starch, microcrystalline cellulose, pregelatinized potato starch, povidone, magnesium stearate, hydrogenated cottonseed oil, sodium lauryl sulfate, hypromellose.
Zentiva oral solution: sorbitol, microcrystalline cellulose and carmellose sodium, methyl-p-hydroxybenzoate, propylhydroxybenzoate, sodium saccharin, polysorbate 20, sodium hydroxide, and water.
Motilium suppositories: tartaric acid, macrogol 4000, macrogol 1000, macrogol 400, butyl hydroxyanisol.
Inactive ingredients may vary depending on the brand or generic version of domperidone you take. Check the product label of the version you take for a full list of ingredients.

Factory

1. Xi'an Sonwu Biotech Co., Ltd has its own factory, so it has adequate stock. Also, Xi'an Sonwu has a clean and tidy production department with advanced equipment. With the lead of Xi'an Sonwu, researchers are constantly developing new products to meet customers' needs.

2. Xi'an Sonwu Biotech Co., Ltd has advanced test equipment and professional testers, which all show that Xi'an Sonwu aims to supply accurate and effective data and good service.

Certificate

Package

Logistics Update

In addition to guaranteeing product quality, the other most vital thing is clients could receive the goods smoothly. So, Xi’an Sonwu supplies all kinds of couriers according to different needs.

Why Choose Us

Our company has been engaged in import-export for over 10 years and has rich experience in the import and export industry.

Our company has 10-year experience in product development, production, and sales.

Our company has a professional team with a clear division of labor.

We have professional laboratories and equipment to ensure high-quality products.

Products are tested by third parties.

We provide OEM service.

We provide 7*24 customer service.

And if you want to know the Domperidone powder price, please contact XI’an Sonwu Biotech Co., Ltd.

Email: sales@sonwu.com

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