Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of spermidine hcl powder in China. We warmly welcome yuo to wholesale bulk spermidine hcl powder for sale here from our factory. Quality products and reasonable price are available.
What Is Spermidine Hcl?
Spermidine hcl powder comes from spermidine hcl, also known as spermidine, N-(3-Aminopropyl)-1,4-butanediamine, which is a small molecular polyamine with a molecular weight of 254.629. Spermidine hydrochloride is biosynthesized from putrescine (butanediamine) and adenosylmethionine, and stable at room temperature. It is found from semen or sperm and is a water-soluble polyamine. Spermidine is consist naturally in all parts of our body and also in many other organisms, such as animals, plants and other food supplements.
N-(3-Aminopropyl)-1,4-butanediamine is a polyamine that inhibits neuronal nitric oxide synthase (nNOS), and can bind and precipitate DNA. At the same time, it can also be used to purify DNA-binding proteins and stimulate T4 polynucleotide kinase activity. According to the study from Germany and Austria scientists on September 1, 2013, spermidine may prevent the onset of Alzheimer's disease, which make it become a good choice as the nootropics in the market. As a professional spermidine hcl manufacturer, Xi'an Sonwu can provide high-quality products with competitive prices. If you want to purchase, please feel free to contact Xi'an Sonwu.
COA of Analysis
How was It Discovered?
The history was dating back to the 17th century. In 1674, Anthony Leeuwenhoek invented the world's first optical microscope and used it to observe many things, including the semen of people, dogs and rabbits. In the process of observing at the semen, he found unknown crystal in the semen. For the next two hundred years, scientists have different hypothesis about the crystal. Vauquelin was thinking it was a phosphate derivative. And Schreiner called the new compound as organic base. Based on it was found in semen, German chemists Ladenburg and Abel eventually decided to name it spermine.
250 years after Leeuwenhoek discovered the crystalline substance from semen, Rosenheim obtained the correct chemical makeup of the crystalline substance. They are putrescine, spermine and spermidine. From then on, spermine has completely appeared in people's field of vision. Later, scientists discovered that it has a variety of miraculous effects, such as improving high blood pressure, protecting cardiovascular, preventing Alzheimer's and so on.
What is Putrescine?
Putrescine, also known as 1,4-butanediamine, is an organic compound that is a colorless crystal or a colorless to slightly yellow liquid at room temperature. Like cadaverine, putrescine is produced by the amino acid degradation of proteins in organisms or corpses. It was first recorded in 1885 by physician Ludwig Brieger of Berlin, Germany. In the formation of polyamines, putrescine reacts with s-adenosyl-3-methylthiopropylamine to produce spermidine. And it interacts with other s-adenosyl-3-methylthiopropylamines to convert spermine.
There are two pathways for the production of putrescine, but both start with the arginine.
The first way is the conversion of arginine to agmatine with the support of arginine decarboxylase. In the next step, agmatine is converted to n-carbamoyl putrescine by agmatine iminohydroxylase. Finally n-carbamoyl putrescine is converted to putrescine. The second way is simply to convert arginine to ornithine, which is then converted to putrescine by ornithine decarboxylase.
Source of Spermidine Hcl
There are four main ways to obtain large amounts of spermidine.
1. It can come from the synthesis of intestinal flora;
2. It is synthesized by the human body itself. It can come from arginine to N-(3-Aminopropyl)-1,4-butanediamine, and can also be converted from spermine;
3. It can come from natural foods, such as wheat germ extract, fruit, meat, soybeans, etc. According to the literature, wheat germ is the best food with the highest content;
4. It can be purchased from manufacturers specializing in the production of this product. You can also take additional supplements if you are not getting enough spermidine in your diet. The synthetic compount used in supplements is the same molecule that occurs naturally.
How Does It Work?
The powder works mainly by activating body autophagy. Autophagy is the process by cells which removing damage cells and reducing the occurrence of apoptosis and carcinogenesis. "Auto" means self and "phagy" means eating.
According to research, with direct use, the heart and muscle will start autophagy within 4 to 24 hours. At the same time, the body's metabolism also enters a state similar to fasting. Oral supplementation usually affects autophagy in cardiac tissue within 2 to 4 weeks and reverses the autophagy deficiency caused by aging.
In addition, it can play a broad-spectrum anti-inflammatory effect, such as inhibiting TNF-α, NFkB.
Advantages of Spermidine Hcl
Spermidine hcl powder has been concerned by many scientists since its discovery. Scientists have published several studies in NATURE and SCIENCE. They found that supplementing or consuming enough spermidine in the diet will have some potential health benefits.
It can improve Alzheimer's;
The supplement is beneficial to human memory function. The Australian team of Professor Reinhart found that the treatment with the powder can improve cognitive function in the elderly. The study included 85 elderly people in 6 nursing homes who were randomly divided into two groups with different doses of intake. After the memory test of their cognitive function, they were then divided into four groups: no dementia, mild dementia, moderate dementia and severe dementia. At the same time, blood samples were collected to evaluate the concentration of N-(3-Aminopropyl)-1,4-butanediamine in the blood. It was found that older adults with mild dementia had significantly improved cognition after taking high doses.
It has anti-aging properties;
N-(3-Aminopropyl)-1,4-butanediamine is a natural polyamine that stimulates autophagy. It can fight against aging in many ways. On the one hand, it can inhibit mTOR. Excessive mTOR activity in the body can promote cancer and accelerate aging. On the other hand, it can activate AMPK, which is an important way to reduce inflammation and burn fat. The supplement can achieve comprehensive anti-aging through these two effects. According to experiments, activation of AMPK by supplementation can prolong 15% lifespan.
It can protect cardiovascular;
The amount of N-(3-Aminopropyl)-1,4-butanediamine in the body decreases with age. The scientists observed that increasing N-(3-Aminopropyl)-1,4-butanediamine intake can reduce cardiovascular disease. In 2016, research published in Arteriosclerosis confirmed that spermidine reduces lipid accumulation in atherosclerotic plaques. In the same year, a study published in Natural Medicine confirmed that it can reduce cardiac hypertrophy and improve diastolic function, thereby achieving the effect of protecting the heart. The researchers then proved that dietary intake of spermidine improved blood pressure and reduced cardiovascular morbidity.
It may improve metabolic diseases;
In 2014, a study in the European Journal of Pathology showed that the supplement improved glucose utilization and reduced body weight in obese mice. In 2017, a study published in Cell Death & Disease showed that it reduced weight caused by a high-calorie diet and improved obesity-related symptoms. These all show that the supplementation can help treat diseases caused by metabolism.
It can delay protein aging.
Different molecular weights proteins may have different roles in the aging process. Some high molecular weight proteins play a key role in controlling the aging process. Once these proteins begin to degrade, aging becomes inevitable. So controlling the degradation of these proteins can delay the aging process. And the ability of the powder to delay aging lies in promoting the synthesis of these proteins or preventing their degradation.
Dosage of Spermidine Hcl
Consuming up to 2 grams per day to take N-(3-Aminopropyl)-1,4-butanediamine as a supplement,. But if you want to take it as a supplement long-term, talk to your doctor ahead of time.
Is Spermidine Hcl Safe?
It is safe. Spermidine is a naturally occurring product in the body and part of the natural diet. According to data, N-(3-Aminopropyl)-1,4-butanediamine supplementation is safe and well tolerated. However please consult your doctor before taking it out of the consideration of your health.
Side Effects of Spermidine Hcl
N-(3-Aminopropyl)-1,4-butanediamine-rich wheat germ extract may contain allergens, such as gluten and wheat. Consult your doctor if you are allergic to any of these compounds or have gluten problems with wheat-based foods.
FAQ
Q1: Are you a manufacturer?
A1: Yes, Xi'an Sonwu is a manufacturer and was established in 2012.
Q2: How to confirm the product quality before placing an order formally?
A2: You can get samples. You only need to pay the freight.
Q3: Can you give me a discount price?
A3: Of course. The more you buy, the greater discount you will have. And Xi'an Sonwu will runs promotions from time to time to help customers get what they want at a price they're satisfied.
Q4: What terms of payment do you accept?
A4: Orders with smaller denominations can be transferred by TT, Western Union or Alibaba payment.
Orders with larger denominations can be transferred to Xi'an Sonwu account by TT.
If you need to buy spermidine hcl powder, you can contact Xi'an Sonwu directly.
E-mail: sales@sonwu.com
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