Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of indole 3 carbinol powder in China. We warmly welcome yuo to wholesale bulk indole 3 carbinol powder for sale here from our factory. Quality products and reasonable price are available.
What Is Indole-3-Carbinol (I3C)
Indole 3 Carbinol powder, also known as I3C, is produced by decomposing glucosinolates, which are found primarily in vegetables such as cauliflower, broccoli, cabbage, and kale. Indole-3-carbinol is formed when cruciferous vegetables are eaten and broken down. Taking indole-3-carbinol supplementation can effectively inhibit the activation of NF-κB and IκBα kinases. Besides, as a dietary supplement due to its antioxidant and anti-atherosclerotic effects. Xi'an Sonwu now provides sufficient indole-3-carbinol. If you are interested, you can contact Xi'an Sonwu at any time.
COA
Where to buy Indole-3-Carbinol
Xi'an Sonwu Biotech Co. ltd, the products produced are strictly controlled in quality and have been rigorously screened from the beginning of the raw materials. In the product production process, we handle every detail well, minimize costs, and enable our customers to get cost-effective products. Many customers have given good feedback to our products after receiving the goods.
To ensure the quality of the products, we can provide samples for testing. Here is the quantity.
| Form | Sample | MOQ |
| Bulk Powder | 10g | 100g |
| Capsules | 200capsules | 200capsules |
| Bottle Capsules | 5bottles | 5bottles |
OEM Service
Xi'an Sonwu not only can supply high quality Indole 3 Carbinol powder, but also supply Indole-3-Carbinol capsules.
So any customers could customize capsules they want. And items below can be supplied.
1. Customized capsules shells (size, color, material)
2. Customized bottles(size, color, material, style)
3. Customized packaging(vacuum foil packaging, box, drum)
4. Customized label(paint film, matte film, optical mask)
What Is I-κ B α kinase
I-κ B α kinase is a serine-specific protein kinase composed of many components. It can be activated by extracellular stimulation and catalyze the phosphorylation of the specific site of I κ B (the inhibitory protein of NF- κ B), resulting in the ubiquitination of I κ B and degradation by 26S proteasome, thus destroying the complex of I κ B and NF- κ B. the released NF- κ B enters the nucleus and starts the gene transcription regulated by it.
What Is Indole 3 Carbinol Used For
1. HPV
Researchers have found that I3C has anti-estrogen activity in HPV-infected cervical cells, which can effectively prevent the proliferation of diseased cells. Not only that, but the researchers also found that I3C enhanced the gene expression of the enzyme 2-hydroxylation and that it binds to the estradiol receptor. Controlled experiments on transgenic mice found that mice fed I3C had a significantly reduced risk of developing HPV disease, suggesting that I3C may help prevent HPV disease.
2. Estrogen
I3C is a negative regulator of estrogen. Using I3C along with other nutrients can prevent the occurrence of major diseases. The combination of I3C and genistein can synergize the effect of DNA damage, thereby increasing apoptosis.
3. Anti-HSV properties
In clinical studies, I3C supplementation has been found to affect herpes simplex virus (HSV). In this study, Vero cells (monkey kidney) and MRC-5 cells (human lung fibroblasts) were treated with I3C at concentrations of 267µM and 375µM, respectively, and then infected with HSV-1 and HSV-2. After I3C, HSV replication was inhibited. These findings all suggest that I3C has anti-HSV properties.
4. Inhibitory effect on Hep-2 cell proliferation
After 48 hours of treatment in the experimental group and the control group at four concentrations, it was shown that indole-3-carbinol inhibited the proliferation of Hep-2 in a concentration-dependent manner and induced apoptosis and Livin protein expression. Indole-3-carbinol can inhibit the proliferation of Hep-2 cells, and its induction of apoptosis may be related to the inhibition of Livin protein expression. With the increase of the concentration of indole-3-carbinol, the word of Livin gradually decreased, suggesting that after the treatment of indole-3-carbinol, the expression of Livin protein was negatively correlated with the apoptosis rate of human Hep-2, indicating that the word of Livin protein may be in Indole-3-carbinol plays a specific role in the process of inducing the apoptosis of human pathological cells, and is safe to other cells without cytotoxicity. Because of its high-efficiency, non-toxic and natural anti-tumor properties, indole-3-carbinol can be used as one of the candidates for prevention and treatment drugs.
Comparison of I3C and DIM
I3C and DIM regulate biotransformed that regulate, metabolize and eliminate steroid hormones, carcinogens, and other harmful biological compounds. However, I3C and DIM are not identical.
I3C is more unstable than DIM and quickly converted to DIM and other substances in the stomach. DIM is converted from I3C, and as a supplement, it advances as an active molecule in the body. I3C and DIM have very similar effects on the body as dietary supplements. But DIM is a more potent ingredient and tends to be preferred.
Side Effects
1. It may interact with certain drugs, such as clozapine and Cymbalta.
2. Cause skin irritation.
3. High doses may cause tremors and gastrointestinal problems at doses as high as 600 mg.
Before taking supplements, talk to your doctor in advance and take the dosage recommended by your doctor.
What to Notice Before Taking Indole 3 Carbinol
1. Indole-3-carbinol is taken under the advice of a doctor
2. It is forbidden to use during pregnancy and lactation
3. Children should take it under the supervision of doctors or parents.
4. Taking indole-3-carbinol two weeks before the operation is forbidden because it may cause bleeding complications during the operation.
What Is the Dosage of Indole-3-Carbinol
Taking indole-3-carbinol depends on the user's age, health, and other factors. There is no exact recommended dosage yet. As a supplement, dosages are usually between 200 and 400 mg per day.
Factory Environment
1.Xi'an Sonwu Biotech Co.,Ltd has its own factory,so it has adequate stock. Also,Xi'an Sonwu has clean and tidy producing department with advanced equipment. With the lead of Xi'an Sonwu, researchers are constantly developing new products to meet customer's need.
2.Xi'an Sonwu Biotech Co.,Ltd has advanced test equipment and professional testers, which all show that Xi'an Sonwu aims to supply accurate and effective data and good service.
Certificates
Packing
Recent Logistics
Except guarantee the product’s, the other most important thing is customers could receive the goods smoothly. So, Xi’an Sonwu supplies all kinds of courier according to different need.
FAQ
1. How to buy products from Xi'an Sonwu
You can contact Xi'an Sonwu via email, phone, and social media.
2.How to ensure the product quality before ordering
Each batch of products needs to be tested to provide customers with COA and other third parties.
3. How to pack and store Indole 3 Carbinol powder
Packaging: export grade sealed drum, vacuum sealed aluminum foil packaging, can also be packed according to customer needs.
Storage: please store in a cool and dry place to avoid bright light and high temperature.
If you want to buy Indole-3-Carbinol, feel free to contact Xi'an Sonwu.
E-mail: sales@sonwu.com
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