Everolimus Powder

Everolimus

Everolimus powder, also known as RAD 001 powder, is a derivative of sirolimus (sirolimus, also known as rapamycin, i.e., rapamycin), so it is also called 40-O-(2-hydroxyethyl)-rapamycin, or 40-O-(2-hydroxyethyl)-sirolimus. RAD 001 is a drug used to treat various cell diseases and other diseases. Its main ingredient is everolimus, an mTOR (mammalian target of rapamycin) inhibitor that works by interfering with cell growth, proliferation, and survival. mTOR is a critical serine-threonine kinase. It can bind to the intracellular protein FKBP12 to form an inhibitory complex, mTORC1, which can inhibit the activity of mTOR. Inhibition of the mTOR signaling pathway can lead to reduced activity of the transcriptional regulator S6 ribosomal protein kinase (S6K1) and the eukaryotic elongation factor 4E-binding protein (4E-BP), thereby interfering with the translation and synthesis of related proteins such as cell cycle, angiogenesis, and glycolysis. It can reduce the expression of vascular endothelial growth factor (VEGF). RAD 001 is a strong inhibitor of fibroblasts, vascular smooth muscle cells, endothelial cells, and sick cells' development and division. It can inhibit glycolysis in solid diseases in vitro and in vivo. If you need, Xi'an Sonwu can supply everolimus. Xi'an Sonwu is looking forward to hearing from you.

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Where To Buy Everolimus

Xi'an Sonwu Biotech Co. Ltd. has rich experience in the global trade and the health industry. Insisting on faith-based and quality first is our company's principle. We strictly control product quality, which means selection starts from raw material. Besides, we handle every detail and reduce costs to the maximum so our customers can get cost-effective products. Based on these, customers have given a lot of good feedback about our products. So look for Xi'an Sonwu Biotech Co. Ltd. when buying RAD 001 powder.

Xi'an Sonwu ensures product quality and can provide samples. Here is the quantity.

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What Is The Mechanism Of Action Of Everolimus

Everolimus functions by preventing the activation of the vital protein kinase known as mammalian target of rapamycin (mTOR), which controls the growth, division, metabolism, and survival of cells. The mechanism of action of RAD 001 involves several steps:

A. Mechanism of Action

1. Binding to FKBP-12:

RAD 001 binds to an intracellular protein called FK506 binding protein 12 (FKBP-12).

2. Inhibition of mTORC1:

The everolimus-FKBP-12 complex specifically inhibits mTOR complex 1 (mTORC1).

mTORC1 is part of the mTOR pathway and is a central cell growth, proliferation, and survival regulator.

3. Downstream Effects:

Cell Cycle Arrest: Cells cannot advance to the S phase, where DNA replication takes place, when mTORC1 inhibition results in cell cycle arrest in the G1 phase. This reduces cell proliferation.

Inhibition of Protein Synthesis: mTORC1 regulates protein synthesis required for cell growth and division. By inhibiting mTORC1, it reduces protein synthesis, further inhibiting cell growth and proliferation.

Angiogenesis inhibition: Additionally, it prevents the angiogenic factors from being produced, which lessens the development of new blood vessels needed for lesion growth and metastasis.

Immune response modulation: It lowers the immune response to the donated organ by preventing T and B cells from activating and proliferating during transplantation.

4. Autophagy induction:

Autophagy is triggered by mTORC1 inhibition and is a process by which cells break down and recycle their constituent parts. This facilitates the elimination of damaged cells or organelles.

B. Clinical relevance

1. Diseased cell therapy: In therapy, it targets diseased cells' growth and proliferation capacity by inhibiting mTORC1, which is often overactive in diseased cells.

2. Transplantation: In organ transplantation, it helps prevent rejection by suppressing the immune response to the transplanted organ.

What Is The Drug Everolimus Used For

Everolimus powder is used to treat a variety of diseases. The following are the primary uses of it:

A. Lesion Cell Therapy

1. Advanced Renal Cell: It treats advanced renal cells after failure of other treatments such as sunitinib or sorafenib.

2. Breast Cell: It is combined with exemestane to treat advanced hormone receptor-positive, HER2-negative breast cells in postmenopausal women previously treated with letrozole or anastrozole.

3. Neuroendocrine Disease: It treats progressive neuroendocrine diseases of pancreatic origin and non-functional lesions originating from the gastrointestinal tract or lungs.

4. Tuberous Sclerosis Complex (TSC)-Related Lesions: It treats TSC-related subependymal giant astrocytes (SEGA) that require therapeutic intervention but are unsuitable for radical surgical resection.

B. Transplantation

1. Kidney Transplantation: It prevents organ rejection in kidney transplant recipients. It is usually used in combination with other immunosuppressants.

2. Liver transplantation: It is also used to prevent organ rejection in liver transplant recipients.

C. Other diseases

Tuberous sclerosis complex (TSC): Besides treating SEGA, it treats patients with TSC-related renal vascular smooth muscle fat who do not require immediate surgery.

RAD 001 functions by preventing the protein known as mammalian target of rapamycin (mTOR), which controls cell division, growth, and survival. It can help slow the growth and spread of sick cells and stop the immune system from attacking the transplanted organ by blocking this mechanism.

What Foods Should You Avoid With Everolimus

When taking RAD 001, certain foods and beverages can interact with the medication, affecting its efficacy or increasing the risk of side effects. Here are the critical dietary considerations:

A. Foods to Avoid

1. Grapefruit and Grapefruit Juice:

Interaction: Grapefruit and grapefruit juice can inhibit the enzyme CYP3A4, which metabolizes it. This may raise the medication's blood levels and increase the chance of adverse effects.

2. Seville Oranges:

Interaction: Similar to grapefruit, Seville oranges (often used in marmalades) can also affect the metabolism of it through CYP3A4 inhibition.

B. Alcohol

Consideration: While not strictly contraindicated, alcohol can exacerbate some side effects of it, such as liver toxicity and gastrointestinal issues. It's best to consult with your healthcare provider about alcohol consumption while on it.

C. High-Fat Meals

Absorption: High-fat meals may affect the absorption of it. Although specific instructions regarding fat intake may not always be provided, taking it consistently with or without food is essential to maintaining stable drug levels.

D.  General Dietary Tips

1. Balanced Diet:

Eating a balanced diet can help control adverse effects such as exhaustion and weight loss. Ensure adequate intake of proteins, fruits, vegetables, and whole grains.

2. Hydration:

Staying well-hydrated is essential, especially if experiencing side effects like diarrhea. Drink plenty of fluids throughout the day.

3. Avoiding Raw or Undercooked Foods:

Due to immunosuppression, patients may be more susceptible to infections. Avoid raw or undercooked meats, eggs, seafood, and unpasteurized dairy products.

E. Consultation with Healthcare Provider

When using everolimus, always get specific dietary guidance from a dietitian or your healthcare professional. Based on your overall health, your treatment plan, and any potential drug interactions, they can offer precise suggestions.

Factory

1. Xi'an Sonwu has a factory with sufficient stock. In addition, Xi'an Sonwu has a clean and tidy production department with advanced equipment. Under the company's leadership, researchers continue to develop new products to meet customers' needs.

2. Xi'an Sonwu has advanced testing equipment and professional testing personnel, all of which show that Xi'an Sonwu aims to provide accurate and effective data and good service.

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Packing

Logistics Update

In addition to guaranteeing product quality, the other most vital thing is that clients receive the goods smoothly. So, Xi'an Sonwu supplies all kinds of couriers according to different needs.

FAQ

1. How to inquire?

We can be reached by phone, email, or social media.

2. How do you guarantee the quality of products?

Each batch must be tested, and COA can be supplied to customers. Additionally, all the products pass the test: HPLC, UV, GC, TLC, etc. We cooperate with third parties as well, like SGS.

3. How do you pack and store?

Pack: Use sealed export-grade drums and vacuum-sealed foil packaging, or pack the goods according to customers' needs.

Storage: You can keep it in a dry and cool place and make it avoid sunlight.

If you want to know about the everolimus powder, you can contact Xi'an Sonwu. Click the email, and then you get high-quality RAD 001 powder.

Email: sales@sonwu.com

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