99% Imatinib Powder

Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of 99% imatinib powder in China. We warmly welcome yuo to wholesale bulk 99% imatinib powder for sale here from our factory. Quality products and reasonable price are available.

What Is Imatinib

99% Imatinib Powder can be used to treat conditions such as chronic myeloid leukemia (CML) and gastrointestinal stromal tumor (GIST). It is classified as a tyrosine kinase inhibitor (TKI), which means it works by targeting and blocking the activity of certain enzymes involved in the growth and proliferation of diseased cells.

One of the enzymes targeted by imatinib is BCR-ABL, a fusion protein with features of CML. This protein is produced when two genes (BCR and ABL) fuse together, resulting in a protein with abnormally high tyrosine kinase activity. This activity promotes the growth and division of diseased cells, which leads to the development of CML. Imatinib works by inhibiting the activity of BCR-ABL, which slows or stops the growth of diseased cells, thereby improving outcomes in CML patients.

In addition to targeting the activity of BCR-ABL, imatinib also targets other enzymes involved in the growth and proliferation of diseased cells. For example, imatinib can inhibit the activity of c-KIT, an enzyme that is overexpressed in certain types of GIST. By blocking the activity of c-KIT, imatinib can slow or stop the growth of these lesions and improve outcomes for patients with GIST.

The purity of our company's Imatinib Powder can reach 99%. Also, our prices are very competitive compared to other companies. If you want to know more, please contact Xi'an Sonwu Biotech Co. Ltd.

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Buy Imatinib Online

Xi’ an Sonwu has rich experience in the global trade and health industry. Reputation-based quality first is the principle of Xi’an Sonwu Company. Xi’an Sonwu strictly controls product quality, so the selection of materials starts with raw materials. Also, we handle every detail and minimize costs so that our clients can get the most cost-effective products. Based on these, customers have given high praise to our products. If you need Imatinib Powder, find Xi’an Sonwu Biotech Co. Ltd.

We completely make sure of the product’s quality, so samples can be supplied. Here is the quantity.

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OEM Service

Xi'an Sonwu not only can supply high quality 99% Imatinib Powder, but also supply its capsules.

So any customers could customize capsules they want. And items below can be supplied.

1. Customized capsules shells (size, color, material)

2. Customized bottles(size, color, material, style)

3. Customized packaging(vacuum foil packaging, box, drum)

4. Customized label(paint film, matte film, optical mask)

What Is the Working Mechanism of Imatinib

Imatinib is a medicine commonly used to treat certain types of conditions, especially chronic myelogenous leukemia (CML) and GIST. It works by targeting the activity of specific enzymes called tyrosine kinases that are involved in the uncontrolled cell growth and proliferation seen in these conditions.

To understand how imatinib works, it is important to first understand the role of tyrosine kinases in CML and GIST. Tyrosine kinases are enzymes involved in signaling pathways that regulate cell growth and division. In CML, genetic mutations lead to the formation of a fusion protein called BCR-ABL, which has constitutive tyrosine kinase activity. This causes white blood cells to grow and divide uncontrollably, which is a hallmark of CML. In GIST, a different type of mutation causes overactivity of another tyrosine kinase called KIT, which is also involved in cell growth and division.

Imatinib works by targeting the ATP-binding site of tyrosine kinases, which is required for their activity. By binding to this site, imatinib prevents the enzyme from functioning as a downstream target in the phosphorylation pathway. This results in the inhibition of several signaling pathways important for cell proliferation and survival, including the Ras/MAPK and PI3K/Akt pathways. As a result, imatinib effectively stopped the growth and division of diseased cells.

Imatinib is a small molecule inhibitor, which means it is able to penetrate cell membranes and reach target enzymes inside the cell. It is highly specific for BCR-ABL and KIT and does not inhibit other tyrosine kinases important for normal cellular function. This specificity is important because it reduces the risk of side effects common with nonspecific kinase inhibitors.

One of the challenges of imatinib therapy is the development of resistance over time. Some diseased cells may acquire additional mutations that allow them to bypass the need for BCR-ABL or KIT signaling, making them insensitive to imatinib. This can lead to disease progression and the need for alternative therapies.

To overcome drug resistance, second-generation tyrosine kinase inhibitors have been developed that inhibit other tyrosine kinases that may be involved in the development of drug resistance. Examples of these drugs include dasatinib and nilotinib. In addition, combination therapies targeting multiple signaling pathways are also being explored to improve therapeutic outcomes.

What Not to Eat with Imatinib

1. Grapefruit: Patients taking imatinib should avoid consumption of grapefruit or grapefruit juice. Grapefruit interferes with the activity of certain enzymes in the liver responsible for metabolizing imatinib. This can lead to higher levels of the drug in the blood, increasing the risk of side effects.

2. St. John's wort: St. John's wort is a popular herbal supplement that is sometimes used to treat depression. However, it can interfere with the activity of certain enzymes in the liver responsible for metabolizing drugs, including imatinib. Patients taking imatinib should avoid taking St. John's wort because it can reduce the effectiveness of the drug.

3. Vitamin C: Although vitamin C is an important nutrient for overall health, high doses of vitamin C may interfere with the activity of imatinib.

4. Alcohol: Patients should avoid drinking alcohol while taking the medicine. Alcohol can increase your risk of liver damage, a rare but serious side effect of imatinib.

5. Fatty or spicy food: Some patients taking imatinib may experience nausea or vomiting as a side effect of the drug. Eating fatty or spicy foods may exacerbate these symptoms, so patients should avoid these types of foods if they experience gastrointestinal side effects.

What Is the Side Effects of Imatinib

1. Common side effects

Nausea and vomiting: One of the most common side effects of imatinib is nausea and vomiting. This can occur shortly after taking the medication and may be mild to moderate in severity.

Diarrhea: Diarrhea is another common side effect of imatinib. This may be mild to moderate in severity and can usually be managed with over-the-counter medications or dietary changes. Rarely, severe diarrhea can occur, which may require hospitalization.

Fatigue: Many patients taking imatinib may experience fatigue or lethargy. This can be due to the medication's effect on the body's energy levels, as well as the emotional toll of living with cancer.

Fluid retention: Imatinib may cause fluid retention, which can lead to edema (swelling) in the legs, feet, or other parts of the body. In some cases, diuretics may be prescribed to help manage this side effect.

Muscle cramps: Some patients taking imatinib may experience muscle cramps or spasms. These may be mild to moderate in severity and can usually be managed with over-the-counter pain relievers or stretching exercises.

2. Less common side effects

Liver damage: Rarely, imatinib may cause liver damage. Signs of liver damage may include yellowing of the skin or eyes (jaundice), dark urine, abdominal pain, or swelling. Patients taking imatinib should have their liver function monitored regularly.

Heart failure: In rare cases, imatinib may cause heart failure. Signs of heart failure may include shortness of breath, fatigue, swollen ankles or feet, and rapid weight gain. Patients with a history of heart disease may be at increased risk of developing heart failure while taking imatinib.

Severe bleeding: While rare, imatinib may increase the risk of severe bleeding. Patients taking imatinib should notify their healthcare provider if they experience any signs of bleeding, such as easy bruising or bleeding gums.

Lung problems: Imatinib may cause lung problems, such as fluid buildup in the lungs or inflammation of the lung tissue. Signs of lung problems may include cough, shortness of breath, or chest pain.

Skin rash: Some patients taking imatinib may develop a skin rash. This may be mild to moderate in severity and can usually be managed with over-the-counter creams or ointments.

Low blood counts: Imatinib may cause a decrease in the number of red blood cells, white blood cells, or platelets in the blood. This can lead to anemia, increased risk of infection, or increased risk of bleeding. Patients taking imatinib should have their blood counts monitored regularly.

How do You Store Imatinib

Here are some guidelines for storing imatinib:

1. Store imatinib at room temperature: Imatinib should be stored at room temperature, which is typically around 20-25 degrees Celsius (68-77 degrees Fahrenheit).

2. Protect from light: Imatinib should be stored in a dark place, away from direct sunlight or other sources of light. This is because light can degrade the medication and make it less effective.

3. Keep in original packaging: Imatinib should be kept in its original packaging until it is ready to be used. This helps protect it from moisture and other environmental factors that can affect its stability.

4. Do not freeze: Imatinib should never be frozen, as this can cause it to break down and become ineffective.

Factory

Xi'an Sonwu is located in a place with beautiful natural environment, covering an area of 10,000 square meters. The factory has advanced production equipment and technical team is well-equipped, clean, and tidy, with sufficient stock. Under the leadership of the company, researchers insist on developing new products. The following is the testing environment of our laboratory, advanced testing equipment, and professional testers, with a strict attitude to providing valuable data for our products and providing our customers with a quality experience.

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Packaging

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In addition to guaranteeing the product quality, the other most vital thing is clients could receive the goods smoothly. So, Xi’an Sonwu supply all kinds of couriers according to different needs.

FAQ

1. How to inquiry?

You can contact us by email, telephone number, or social media.

2. How to guarantee the quality of products?

Each batch needs to be tested so we can supply COA for customers. Additionally, our products pass the test: HPLC, UV, GC, TLC, etc. And we also cooperate with third parties, like, SGS.

3. How to pack and store the product?

Pack: Vacuum sealed foil packaging & Sealed export grade drum or pack according to customers' need

Storage: For a short time, you can keep it in a dry and cool place and make it avoid sunlight.

If you are interested in our company's 99% Imatinib Powder, please contact Xi'an Sonwu Biotech Co. Ltd.

Email: sales@sonwu.com

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