Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of palmitoylethanolamide bulk in China. We warmly welcome yuo to wholesale bulk palmitoylethanolamide bulk for sale here from our factory. Quality products and reasonable price are available.
What Is Palmitoylethanolamide Used for
Palmitoylethanolamide bulk is an endogenous cannabinoid found in the brain, liver, and other mammalian tissues. It is a weak ligand of cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptors and has been found to inhibit fatty acid amide hydrolase (FAAH) (IC50 = 5.1um). Regulate the activation of mast cells. Palmitoethanolamide powder has anti-injurious, anti-inflammatory, anticonvulsant, and immunosuppressive activities. It is a kind of N-(long chain acyl) ethanolamine, an endogenous cannabinoid, and a kind of N-(saturated fatty acyl) ethanolamine. It is derived from hexadecanoic acid. Palmitoethanolamide powder acts by binding to unknown cannabinoid receptors similar to CB2. It also works as a selective activator of GPR55 receptors.
Palmitoethanolamine powder (also known as palmitoylethanolamide or NMel 2 hydroxyethyl palmitate) is one of the most important endogenous analgesic and anti-inflammatory compounds and has been shown to be effective against both acute and chronic pain. Because it can be used as a natural painkiller, it is an excellent substitute for traditional medicines that may cause side effects.
Certificate of Analysis
ANALYSIS | SPECIFICATION | RUSULT |
Appearance | Fine White Crystal Powder | |
Identification | Positive | Positive |
Loss on Drying | ≤1% | 0.32% |
Water | ≤1% | 0.15% |
Residue on Ignition | ≤0.1% | 0.07% |
Purity(HPLC) | ≥99% | 99.12% |
Heavy Metal | ||
Pb | ≤0.5mg/kg | Conforms |
As | ≤0.15mg/kg | Conforms |
Cd | ≤2.5mg/kg | Conforms |
Hg | ≤1.5mg/kg | Conforms |
Solvent Residue | ||
Methanol | ≤0.3% | Not Detected |
Ethanol | ≤0.5% | Not Detected |
Ethyl Acetate | ≤0.5% | Not Detected |
Microbiological Control | ||
Total Plate Count | ≤1000cfu/g | Conforms |
Yeast and Mold Count | ≤100cfu/g | Conforms |
Total Coliforms | ≤10cfu/g | Conforms |
E. Coli | Absent/10g | Conforms |
S. aureus | Absent/10g | Conforms |
Salmonella | Absent/25g | Conforms |
Who Manufactures Palmitoylethanolamide in China
Xi'an Sonwu Biotech Co. ltd. has rich experience in global trade and health industry. Insisting on faith-based and quality first is our company’s principle. We strictly control product quality, which means selection starts from raw material. Besides, we handle every detail and reduce cost to the maximum extent, then our customers can get cost-effective product. Based on these, customers have given much good feedback to our products. So look for Xi'an Sonwu Biotech Co. ltd. when buy raw PEA powder.
Xi'an Sonwu completely makes sure product’s quality, so sample can be supplied. Here is the quantity.
Form | Sample Amount | The Minimum of Quantity |
Powder | 10g | 10g |
Bulk Capsules | 200 capsules | 200 capsules |
Bottled Capsules | 5 bottles | 5 bottles |
Customers’ Good Comment
OEM Service
Xi'an Sonwu not only can supply high quality palmitoylethanolamide bulk powder, but also supply palmitoylethanolamide capsules.
So any customers could customize capsules they want. And items below can be supplied.
1. Customized capsules shells (size, color, material)
2. Customized bottles(size, color, material, style)
3. Customized packaging(vacuum foil packaging, box, druOm)
4. Customized label(paint film, matte film, optical mask)
What Are the Uses for Palmitoylethanolamide
Palmitoylethanolamide is an endogenous fatty acid amide, an analog of endogenous cannabinoid anandamide (AEA), and belongs to the N-acylethanolamine (NAE) family. NAE is released from the cell in response to harmful stimuli. Like all NAE, palmitoylethanolamide (PEA) powder has a local effect, and the balance of production and degradation activity closely regulates its tissue level. Two lactamases expressed in inflammatory cells are involved in lipid amide degradation: fatty acid amide hydrolase (FAAH) and N-acyl ethanolamine hydrolase (NAAA). Palmitoethanolamide (PEA) powder has been shown to bind to nuclear receptors (nuclear receptors) and perform various biological functions related to chronic pain and inflammation.
What Is the Mechanism of Action of Palmitoylethanolamide
Palmitoethanolamide powder can activate PPAR α, which boosts energy, burns fat, and resists inflammation. By activating this key protein, palmitoylethanolamide powder blocks the activity of pro-inflammatory genes and the production of many inflammatory substances.
Palmitoethanolamide powder decreased the activity of bliss gene FAAH which decomposes natural cannabinoid anandamide. This increases the level of sedative anandamide in the body, which helps fight pain and increase relaxation. It may also activate cannabinoid receptors (CB2 and CB1).
Palmitoethanolamide powder contains palmitic acid in its structure. It is this saturated fatty acid that makes palmitoylethanolamide powder in the body.
However, simply increasing the intake of palmitic acid or other dietary fat does not affect the production of palmitoylethanolamide powder in the body. This is because your body uses palmitoylethanolamide powder only when it needs to compensate for inflammation or pain; its levels usually change throughout the day. The best way to get the benefits of palmitoylethanolamide powder is through standardized supplements or foods rich in palmitoylethanolamide powder.
When Was Palmitoylethanolamide discovered
Palmitoethanolamide (PEA) powder is a natural amide of ethanolamine and palmitic acid, an endogenous lipid regulating pain and inflammation. Coburn et al first noticed the anti-inflammatory properties of palmitoyl ethanolamide powder in the early 1950s. (1954), who found that feeding guinea pigs foods with high yolk content could protect them from experimental allergies. In the following study, palmitoylethanolamide powder was isolated and purified from egg yolk, and the anti-inflammatory properties of animals were determined. After the discovery of another endogenous NAE AEA, interest in NAE was revived in the 1990s, and the NAE has characteristics similar to those of the active component of cannabis. The cloning of cannabinoid receptors (designated as CBi and CB2) and the production of selective CB receptor ligands provide tools to accelerate research activities further. Since then, a great deal of evidence has been collected from animal and human studies that palmitoylethanolamide powder has anti-inflammatory and analgesic effects when administered through different administration routes.
More Research
Palmitoethanolamide (PEA) powder is a natural substance produced by the human body which exists in all kinds of food. It's not an opioid. It's not addictive. Preliminary studies have shown that Palmitoylethanolamide (PEA) Powder does not produce pharmacological tolerance and does not gradually lose its efficacy over time, as opioids do. It is safe for patients with no severe side effects and has no acute or chronic toxicity. It does not interfere with other drug treatments or trigger drug interactions. Palmitoylethanolamide (PEA) Powder has no known contraindications. Patients with decreased renal and liver function can be treated with Palmitoylethanolamide (PEA) Powder because its metabolism is local and cellular and has nothing to do with kidney and liver function. As with many drugs, the safety of long-term use for more than 60 days has yet to be thoroughly studied, although no problems have been reported in the literature.
Factory Envionment
1. Xi'an Sonwu has a factory with sufficient stock. In addition, Xi'an Sonwu has a clean and tidy production department with advanced equipment. Under the company's leadership, researchers continue to develop new products to meet customers' needs.
2. Xi'an Sonwu has advanced testing equipment and professional testing personnel, all of which show that Xi'an Sonwu aims to provide accurate and effective data and good service.
Certificates
Packaging
Logistics Record
In addition to guaranteeing the product quality, the other most vital thing is clients could receive the goods smoothly. So, Xi’an Sonwu supplies all kinds of couriers according to different needs.
Company's Profile
Xi’an Sonwu Biotech Co . Itd is a professional Chinese manufacturer and products supplier. It was founded in 2012, and located in Hi-Tech industrial Zone Xi’an city, Shannxi province, China. It pays all attention on development, research and production of food additives, plant extract , APl and other ingredients of health care products. Our company supplies five kinds of raw material products: Anti-hair loss Powders, Nootropic, API, Muscle Building products, Plant Extract. We sincerely believe that the premise of a great cooperation is best services and good quality. So, welcome your inquiry.
If you want to know palmitoylethanolamide bulk price, feel free to contact Xi'an Sonwu.
E-mail: sales@sonwu.com
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