Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of agomelatine powder in China. We warmly welcome yuo to wholesale bulk agomelatine powder for sale here from our factory. Quality products and reasonable price are available.
What is Agomelatine?
Agomelatine powder is an atypical antidepressant used to treat severe depressive disorders. It mainly blocks some serotonin receptors and excites melatonin receptors. Its receptor binding spectrum may have a unique effect on receptor coupling signal processes and downstream signal pathways, not only in mood disorders, but also in CRSWDS. Agomelatine maintains long enough by inducing adenosine cyclase sensitization to support the inhibitory effect of PER1 protein on PER2 protein, thereby inhibiting the activity of monoamine oxidase A, thus increasing dopamine release from prefrontal cortex and striatum, thus promoting resynchronization.
According to the survey, Agomelatine has the same effect as other antidepressants, but withdrawal is rare. In addition, it also helps to improve the circadian rhythm, restore the non-rapid eye movement (NREM-REM) sleep cycle in nocturnal sleep, increase the incremental power ratio, and advance the phase of circadian rhythm and sleep-awakening cycle. So it may improve sleep. In a word, Agomelatine has obtained high popularity in the market. Xi'an Sonwu is a professional manufacturer of Agomelatine for more than ten years, can provide customers with high quality products. If you want to buy Agomelatine, please feel free to contact Xi'an Sonwu.
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What is agomelatine used for?
1. Mood Disorders
Agomelatine powder has a unique pharmacological mechanism, that is, regulating the sleep awakening cycle, so it can regulate the sleep structure of patients at night to improve sleep. By stimulating the melatonin receptor, agomeladine is hypothesized to resynchronize circadian rhythms with the external environment. Patients with depression often have difficulty in falling asleep, early awakening or sleep rhythm changes. Polysomnography often shows a decrease in slow wave sleep (SWS), an increase in the density or latency of rapid eye movement sleep (REM), and a decrease in the proportion of δ sleep. Most antidepressants, such as tricyclic antidepressants (TCA) and selective 5-HT reuptake inhibitors (SSRI), can regulate REM, but have poor effect on non-REM sleep, especially SWS.
Some drugs with 5-HT2 receptor blocking effect, such as Mianserin mianserine) and mirtazapine, can promote sleep and improve sleep persistence, but the blocking effect can cause sleep, daytime drowsiness and so on.
2. Anxiety Disorders
In clinical trials, Agomeladine has demonstrated its ability to improve anxiety symptoms in severe depression. Studies have shown that the antidepressant mechanism of agomelatine may be related to the increase of neuronal plasticity and neuronal proliferation in the hippocampus. The proliferation, regeneration and death of nerve cells in the brain of adult rats were measured by immunostaining. The results showed that long-term administration of Agomeladine (3 weeks) could increase the proliferation of cells and neuronal regeneration in the ventral dentate gyrus of hippocampus. This site is related to emotional response. However, no similar situation was found during acute or subacute administration (4 hours or 9 weeks). After prolonged administration, cell proliferation and neuronal regeneration appeared in the whole dentate gyrus, indicating that Agomeladine can increase hippocampal nerve regeneration in varying degrees, resulting in the production of new granulosa cells.
3. Fibromyalgia
Agomelatine may relieve neuropathic pain by blocking 5-HT2C receptor. The existing research has several limitations: small sample size, short duration and lack of control group. In addition, patients with fibromyalgia have a high prevalence of depression and anxiety disorders.Therefore, because of its antidepressant effect, it is difficult to separate the improvement of fibromyalgia from Agomelatine. Through 10 placebo-controlled trials, it was found that atomeladine had a short-term effect on severe depressive disorder.At the end of the trial, 6 of the 10 short-term double-blind placebo-controlled trials were effective, proving the effectiveness of antidepressants. In 2018, through a systematic investigation and network summary analysis of the efficacy and acceptability of 21 antidepressants, it was found that agmelatine was one of the most effective drugs and the only one more tolerant than placebo. In a meta-analysis, isoproterenol was found to be effective in the treatment of severe depression. The more severe the degree of depression, the stronger the antidepressant effect. In a human controlled study, amloxetine has the same efficacy as SSRI antidepressants paroxetine, sertraline, aspirin and fluoxetine in the treatment of severe depression.
4. Function of BDNF
Hippocampal BDNF may enhance synaptic plasticity, which may theoretically improve the brain's ability to learn, store and obtain new information. Will Agomelatine increase the level of BDNF in the hippocampus, thereby promoting the survival of existing neurons and synapses and the growth and production of new neurons and synapses? the researchers believe that Agomelatine may affect the long-term behavioral response to stress to alleviate the symptoms of mood disorders.
And physically enhance the brain's ability to cope with stressful situations.
5. Effects on Bones and Muscles
Whether agomelatine lowers levels of pro-inflammatory cytokines IL-1 β and IL-6 is being studied. In theory, agimolatine affects bone health by inhibiting these potentially harmful cytokines.
However, the effect of raw agomelatine on human bone health is not clear. Agomelatine increases IGF-1 and growth hormone levels by stimulating melatonin receptors, which regulate hormone secretion during sleep. Some researchers hypothesized that agomelatine increases IGF-1 and growth hormone levels by stimulating melatonin receptors, which regulate hormone secretion during sleep, potentially its effect on muscle strength. Rodents treated with agomelatine showed an increase in muscle strength and density, while muqian showed a complete lack of clinical data.
How much agomelatine should I take?
The recommended dose is 25mg, once a day, orally before going to bed. If the symptoms do not improve after 2 weeks of treatment, you can increase the dose to 50mg once a day and take it before going to bed.
All patients should check their liver function before starting treatment, and patients with elevated transaminase levels above the normal limit should not start treatment. Transaminase levels should be monitored regularly during treatment and regularly reviewed at 3 weeks, 6 weeks (end of acute treatment), 12 weeks and 24 weeks (end of maintenance treatment).
After that, the examination can be carried out according to clinical needs. Treatment should be stopped when the level of transaminase exceeds the normal limit. When the dose increases, liver function tests should be performed again at the same frequency as the initial treatment. People with depression should be given sufficient treatment cycles (at least 6 months) to ensure that the symptoms disappear completely.
Due to the lack of data on safety and effectiveness, it is not recommended for children under the age of 18, adolescents and women during pregnancy or breastfeeding. Please use it according to your doctor's instructions before using it.
Agomelatine side effects
1. Common adverse reactions include
Hyperhidrosis, abdominal pain, nausea, vomiting, diarrhea, back pain, fatigue, headache, dizziness, anxiety
2. Unusual adverse reactions include
Blurred vision, Eczema, Pruritus, Urticaria, Agitation, Irritability, Restlessness
According to current information, the overall side effects of pure agmoratine powder seem to be relatively mild. For example, Agomelatine does not have drug withdrawal syndrome, rarely shows sexual dysfunction, and is usually weight-neutral. The drug seems to be relatively safe in case of an overdose. However, it is worth noting that 1% of patients have elevated liver transaminase during treatment.
Overall, if further evaluation of clinical trials supports reasonable risk, then Agomelatine may be a unique pharmacological supplement in psychiatric and primary care settings and in the clinical warfare of depression.
Factory
Xi'an Sonwu has its own production plant, professional R & D personnel and advanced testing and manufacturing equipment. Under the condition that the laboratory is well-equipped and the experimental environment is clean and tidy, R & D personnel continue to develop new products, improve product concentration, provide accurate and effective data for products, meet the different needs of customers, and provide quality service for customers. In addition, the factory has extremely sufficient storage space, which can provide customers with sufficient inventory supply at any time to facilitate timely delivery.
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Shipping and Packing
FAQ
1. How do I buy products from Xi'an Sonwu?
You can contact Xi'an Sonwu via email, phone, and social media.
2.How to ensure the product quality before ordering?
Each batch of products needs to be tested to provide customers with COA.
In addition, all products not only passed the detection of high performance liquid phase, ultraviolet, gas chromatography and thin layer, but also cooperated with SGS and other third parties.
3. How to pack and store Agomelatine?
Packaging: export grade sealed drum, vacuum sealed aluminum foil packaging, can also be packed according to customer needs.
Storage: please store in a cool and dry place to avoid bright light and high temperature.
If you have interest and want to buy Agomelatine powder, please contact Xi'an Sonwu.
Email ID: sales@sonwu.com
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