Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of flibanserin powder in China. We warmly welcome yuo to wholesale bulk flibanserin powder for sale here from our factory. Quality products and reasonable price are available.
What Is Flibanserin
Flibanserin powder is a kind of good raw material of suplements that boosts sex drive for women. Flibanserin was the first drug approved by the FDA in August 2015 for treating premenopausal women with decreased libido (HSDD). It was initially developed as an antidepressant but showed a lack of efficacy in research and was further developed as a sexual hypofunction drug. The mechanism of action of flibanserin is attributed to its high affinity for 5-HTA2 and 5-HTA1 receptors, showing agonist activity to 5-HTA1 and antagonist activity to 5-HTA2, resulting in the decrease of serotonin in the brain and the effect on norepinephrine increase and dopamine neurotransmitter.
Due to its good effect, there are more and more flibanserin manufacturer. Xi'an Sonwu Biotech Co. Ltd. Promises to supply high purity flibanserin. If you are interested, welcome your enquiry anytime.
Certificate of Analysis
Items | Specifications | Results |
Appearance | White powder | Conforms |
Assay （HPLC） | ≥99.0% | 99.9% |
Loss on Drying | ≤1.0% | 0.5% |
Solubility | Soluble in water and 95%ethanol, sparingly soluble in acetic anhydride and practically insoluble in diethyl ether | Conforms |
PH | 5-6 | Conforms |
Identification | HNMR spectrum meet the reference | Conforms |
Melting Point | 132-133 Celcius Degree | Conforms |
Clarity and Color of Solution | Clear and Colorless | Conforms |
Sulfate | 0.05% Max | Conforms |
Heavy Metals | 10ppm Max | Conforms |
As | 2ppm Max | Conforms |
Organic Acid(0.1M NaOH) | 0.5ml Max | Conforms |
Loss on Drying | 0.5% Max | Conforms |
Residue on Ignition | 0.1% Max | Conforms |
Residual Organic Solvents (GC) | Xylol 0.22% Max | Conforms |
Isopropanol 0.5% Max | Conforms | |
Related Substances(HPLC) | Total impurity 1.5% Max | Conforms |
Single impurity 0.5% Max | Conforms |
Customers’s Good Comment
The Pharmacokinetics of Flibanserin
Flibanserin showed linear and dose-proportional kinetics after a single oral dose (5mur150 mg) and multiple oral doses (the total daily amount ranged from 60 to 300 mg). It is absorbed by 90%, with an average half-life of about 11 hours. When there is mild liver function damage, the half-life increases to 26 hours. Taking medicine with food will increase its absorption. It has 98% protein binding, mainly to albumin. Its oral bioavailability was 33%. Flibanserin does not reach a stable state until three days after administration, so it is incorrect to call it "female Viagra" because Viagra is used on demand.
To a lesser extent, Flibanserin is oxidized by CYP3A4 and CYP2D6 cytochrome P450 isozymes. Simultaneous use of CYP3A4 inhibitors may increase flibanserin exposure and is taboo. Flibanserin can be used two weeks after the last use of moderate or potent CYP3A4 inhibitors.
Moderate or vigorous CYP3A4 inhibitors can start two days after the last administration of flibanserin. Strong CYP3A4 inhibitors include ketoconazole, itraconazole, clarithromycin, nefazodone, ritonavir, indinavir, and conivaptan. Moderate CYP3A4 inhibitors include atazanavir, ciprofloxacin, diltiazem, verapamil, erythromycin, fluconazole, and grapefruit juice. Oral administration of weak CYP3A4 inhibitors such as contraceptives, cimetidine, fluoxetine, ginkgo biloba, and ranitidine may be associated with an increased risk of hypotension, syncope, and central nervous system (CNS) depression.
In addition, the CYP3A4 inducer can significantly reduce the concentration of flibanserin, so it is not recommended to use it simultaneously. These include piperacillin, carbamazepine, phenobarbital, phenytoin sodium, rifampicin, and St. John's grass.
The use of flibanserin in patients with weak metabolism in CYP2C19 leads to increased flibanserin concentration and may increase the risk of hypotension and syncope. The adverse reactions of these patients should be closely monitored. These drugs include proton pump inhibitors, selective serotonin reuptake inhibitors, benzodiazepines, and antifungal agents.
Flibanserin inhibits P-glycoprotein. Monitoring the concentration of P-glycoprotein transporters with a narrow treatment index, such as digoxin and sirolimus, needs to be strengthened.
Flibanserin is excreted mainly through bile and kidneys as inactive metabolites.
What Is the Mechanism of Action of Flibanserin
Flibanserin is a new multifunctional serotonin agonist and antagonist.
Libido is actively regulated by synaptic dopamine and other microcircuits affected by norepinephrine, testosterone, and estrogens. Libido is negatively regulated by microcircuits acting on prolactin and serotonin. It is suggested that the relative deficiency of dopamine and norepinephrine in the microcircuit or the relative excess of serotonin in the microcircuit can lead to sexual interest and libido disorders.
Flibanserin has two main pharmacological effects in neural microcircuits: it acts as a complete agonist of the postsynaptic 5HT1A receptor and an antagonist of the postsynaptic 5HT2A receptor. Exclusive binding to these receptors distinguishes flibanserin from buspirone and bupropion. This effect in the prefrontal cortex leads to a decrease in the downstream release of dopamine and norepinephrine and a reduction in serotonin, consistent with the abnormal neuroimaging sites described in patients with decreased sexual interest and libido. Flibanserin selectively acts on pyramidal neurons that excite 5HT neurons in the brainstem but also selectively acts on pyramidal neurons that inhibit norepinephrine and dopamine neurons in the brainstem.
Flibanserin Dose
Take 100mg flibanserin powder orally before going to bed every day.
Administration during waking hours increases the risk of hypotension, syncope, accidental injury, and depression. If there is no improvement, the drug will be stopped after eight weeks.
If missed, the patient should take the next dose before bed the next day. The amount should not be doubled.
At present, it does not apply to postmenopausal women or men. Nor does it show that it can improve sexual ability.
Flibanserin Side Effects
Flibanserin may lead to central nervous system inhibition with drowsiness and sedation. Fatigue, insomnia, and dry mouth can also occur. Patients should not drive or engage in activities requiring full vigilance at least 6 hours after taking flibanserin. Simultaneous use of central nervous system inhibitors such as diphenhydramine, opioids, sleeping pills, and benzodiazepines may increase this risk.
Flibanserin itself can cause hypotension and syncope.
Mouse studies have shown that the incidence of malignant breast tumors in female mice increased dose-dependent when exposed to 3 and 10 times the recommended clinical dose. This was not seen in male mice or male or female rats. But, the clinical significance of these findings is unclear.
Controversy Over Flibanserin
Does HSDD exist? Given that it is no longer included in the DSM-V as a separate entity, is drug therapy the right way forward?
Is flibanserin safe enough to recommend the use? Flibanserin safety and side effect dates are still being accumulated. According to a meta-analysis by Jaspers et al., premenopausal and postmenopausal women who took flibanserin experienced 0.5 more satisfying sexual encounters per month and scored 0.3 points higher on a 5-point libido scale. They concluded that these modest benefits did not outweigh the harms. According to the FDA, flibanserin increased drowsiness, sedation, or fatigue compared to placebo: 21% vs. 8%!
Approval controversy: in 2009, Boehringer Ingelheim put in approval of flibanserin for HSDD in premenopausal women. However, FDA's clinical reviewers and external advisory committees voted unanimously against the drug by 11-0. This is because the drug has been noted to cause severe drowsiness and not safe interactions with alcohol and other drugs and fails to improve libido as measured by daily electronic diaries. Boehringer's right to sell flibanserin to Sprout, Sprout was resubmitted to FDA for approval in 2013 but was rejected again. FDA concluded that the drug had "little difference in treatment compared to placebo" and "did not significantly outweigh safety concerns." In 2015, Sprout again submitted flibanserin to FDA, and the drug was approved. However, the resubmit does not contain new revenue data! Within 48 hours of the FDA's approval, flibanserin was sold to Valeant Pharmaceuticals for about $1 billion in cash.
Factory Environment
1.Xi'an Sonwu Biotech Co.,Ltd has its own factory,so it has adequate stock. Also,Xi'an Sonwu has clean and tidy producing department with advanced equipment. With the lead of Xi'an Sonwu, researchers are constantly developing new products to meet customer's need.
2.Xi'an Sonwu Biotech Co.,Ltd has advanced test equipment and professional testers, which all show that Xi'an Sonwu aims to supply accurate and effective data and good service.
Certificates
Packaging
Logistics Record
In addition to guaranteeing the product quality, the other most vital thing is clients could receive the goods smoothly. So, Xi’an Sonwu supply all kinds of couriers according to different needs.
Why Choose Xi'an Sonwu Biotech Co.,Ltd
Our company has been engaged in import-export for over 10 years and has rich experience in import and export industry.
Our company has 10-year experience in product development, production and sales.
Our company has a professional team with clear division of labor.
We have professional laboratories and equipment to ensure high quality products.
Products are tested by third parties.
We provide OEM service.
We provide 7*24 customer service.
If you want to know flibanserin powder price, welcome to enquire.
E-mail: sales@sonwu.com
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