Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of cb-03-01 powder in China. We warmly welcome yuo to wholesale bulk cb-03-01 powder for sale here from our factory. Quality products and reasonable price are available.
Description of CB-03-01
CB-03-01 powder derives from CB-03-01, which is a synthetic steroidal antiandrogen–specifically, an androgen receptor antagonist – which is used as a topical medication in the treatment of androgen-dependent conditions including acne vulgaris and androgenic alopecia (male-pattern hair loss).
Actually, CB-03-01 is the developmental code name of Clascoterone whose chemical name is 21-hydroxy-17-(1-oxopropoxy)pregna-4-ene-3,20-dione, sometimes abbreviated as: 11-Deoxycortisol 17α-propionate (Cortexolone 17α-propionate).
In fact, CB-03-01 comes in two different brand names. The brand name Winlevi is used for clascoterone cream which is currently 1% of concentration is primarily meant for treating acne. In comparison, Breezula (7.5% concentration) is the brand name for an anti-androgenic medication intended to tackle the underlying cause of hair loss, which is what we're talking about today. The anti-androgenic activity of CB-03-01 acts locally only in the superficial layer of the skin.
The powder, after entering the body, no longer has anti-androgenic activity, so it does not affect hormones in the body. And it has stronger activity and ability than our common anti-androgen drugs, which is its unique feature. Therefore, many people are optimistic about its prospects, hoping that it will become an effective drug for hair loss. As one of CB-03-01 manufacturer and supplier, Xi'an Sonwu provides high quality products with reasonable price. If you take an interest in CB-03-01, welcome to contact Xi'an Sonwu.
Specification
ANALYSIS | SPECIFICATION | RUSULT |
Appearance | White Crystalline Powder | Conforms |
Identification | HNMR | Conforms |
LCMS | Conforms | |
Impurity | ≤0.4% | Conforms |
Ignition Residue | ≤0.1% | Conforms |
Any Single Impurity | ≤0.65% | ≤0.5% |
Total Impurities | ≤2.0% | ≤1.0% |
Granularity D90 | ≤110µm | ≤100µm (160 mesh) |
Assay(HPLC) | ≥99% | 99.75% |
Conclusion | Conforming to Enterprise Standard | |
HPLC Test
Background Information of CB-03-01
CB-03-01 powder is used mainly to treat Androgenetic alopecia (AGA), or most commonly called male pattern baldness, which is a common genetically determined hair disorder that can affect both men and women. AGA affects 50% of men and 13% of premenopausal women and greatly increases in postmenopausal women. Our hair normally grows in cycles of 2 to 6 years, but with people who are suffering from AGA, these cycles are shortened to 6 to 8 months. Over time these hairs become miniaturized and get progressively thinner and shorter. AGA is the most common type of hair loss.
Typically, hair loss in androgenetic alopecia happens in a pattern, first receding above the temples and thinning at the crown, with these bald or thin spots ultimately converging.
The primary cause of this hair miniaturization process is the sensitivity of the scalp to the androgen called Dihydrotestosterone (DHT). DHT is made from testosterone via the enzyme 5 alpha-reductase. Increased DHT activity or sensitivity to DHT is associated with hair loss. DHT binds to androgen receptors in hair follicles, which ultimately shortens the hair cycle and contributes to miniaturization of the follicles.
In April 2019, the Italian-based pharmaceutical company, Cassiopea, released a press statement that enthused the hair loss community. They revealed that their innovative product, Clascoterone or CB-03-01, "stops the loss of hair, and grows new hair." According to them, the drug is an anti-androgen, which inhibits the ability of DHT to bind with androgen receptors in the scalp. This action reportedly reduces hair miniaturization, or thinning and loss.
As the drug has moved through phase II clinical trials, Cassiopea has documented the so-far positive results through a series of press releases.
The latest and largest analyses of the drug's effectiveness involved 400 subjects in Germany and lasted 12 months. The phase II trial participants, each with mild to moderate androgenetic alopecia, used four different dosages of CB-03-01. All groups saw an increase in target hair counts and hair widths during the study period, and positive changes in their hair growth assessment (HGA, a questionnaire for study participants). The placebo group, on the other hand, saw worsening of their hair loss when left untreated. According to the research: "these data confirm that CB-03-01 stops the loss of hair and grows new hair." As for safety, the manufacturer says there have been no "treatment-related serious adverse events" among patients in the clinical trials, declaring their drug as safe and free of side effects.
Working principle of CB-03-01
CB-03-01 or Clascoterone is an androgen receptor antagonist with a steroidal structure. It antagonizes dihydrotestosterone (DHT) through competitive binding with cytoplasmic androgen receptors as it shares the same fused four-ring backbone structure. The primary explanation is that it blocks the androgen receptor responsible for hair loss.
When applied to the skin, the formulation penetrates the surface and reaches the androgen receptors within the hair follicles and the adjacent sebaceous glands. There is no evidence yet regarding the systemic absorption of clascoterone when applied topically. Its mechanism of action is illustrated in the image below:
Androgenetic alopecia occurs when the dihydrotestosterone (DHT) binds to the androgen receptors within the sebaceous gland and the hair follicles. This causes the hair cycle to become shorter, and the scalp follicles start to miniaturize. The characteristic pattern of baldness occurs when the hair follicles spontaneously become smaller and thinner, and they cannot produce any new hair. The good thing about DHT-dependent androgenetic alopecia is that it can be partially reversed, and the progression can be slowed down. This is best done by blocking the interaction between DHT and the androgenic receptor. As a result, androgenetic alopecia should respond well to androgen receptor blockers like CB-03-01. What makes CB-03-01 unique is that its mechanism of action doesn't influence hormonal activity in the body. Thus, besides topical Finasteride, which is relatively safe to use, CB-03-01 is another weapon in the arsenal of anti-androgen medications that can effectively be used against hair loss.
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Why Choose Us
1. Xi'an Sonwu has been engaged in import-export for over 10 years with rich experience in import and export industry.
2. Xi'an Sonwu has a professional team with clear division of labor.
3. OEM service is available.
4. Products are tested by third parties.
If you want to buy CB-03-01 Powder, please contact Xi'an Sonwu.
Email ID: sales@sonwu.com
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