Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of nsi-189 phosphate in China. We warmly welcome yuo to wholesale bulk nsi-189 phosphate for sale here from our factory. Quality products and reasonable price are available.
Product's Introduction
NSI-189 phosphate comes from NSI-189, an experimental neurogenic compound that may potentially treat MDD(Major Depressive Disorder), traumatic brain injury, stroke, cognition problems, mental disorders, post-traumatic stress disorder, and neurodegenerative disease due to aging. The chemical is being investigated as an alternative drug designed for patients who failed to respond to conventional medications. At present, NSI189 is still being tested for other conditions such as improved brain health, diabetic neuropathy, stroke, neurodegenerative disease, post-traumatic stress disorder, and Angelman syndrome. It is used to treat traumatic brain injury.
Specification
ANALYSIS | SPECIFICATION | RUSULT |
Appearance | Off-white Powder | Conforms |
Identification | IR and HPLC spectrum shall conform to the standard sample. | Conforms |
Melting Point | 83℃~86℃ | 84.3℃~85.5℃ |
Loss on Drying | Less than 0.5% | 0.28% |
Purity (on dried base, HPLC) | NLT 99.4% | 99.6% |
Total Impurity | Less than 0.5% | 0.4% |
Residue on Ignition | ≤0.2% | 0.13% |
Heavy Metal | ≤20ppm | Conforms |
Conclusion | Conforming to Enterprise Standard | |
Mechanism of Action
The neuropsychopharmacological effects of NSI-189 have not yet been fully discovered by researchers. Here are some of the mechanisms which researchers have explored and found involved in the effects of NSI-189.
NSI-189 is a novel neurogenic antidepressant. Neurogenic drugs promote the development and growth of new neurons, or brain cells. This means that NSI-189 could potentially repair damaged or missing brain cells that lead to a person being unable to experience happiness or, in other words, who are depressed. According to the research, it's believed that it may help in treating depression and reducing the cognitive symptoms of depression and anxiety.
NSI-189 phosphate may promote neurogenesis in the hippocampus-derived neural stem cell and affect the parts responsible for learning, memory, and emotion. This happens along with different processes. The drug is a benzylpiperazine-aminopyridine that may pass the blood-brain barrier.
Neurogenesis is stimulated in the hippocampal slices, specifically the left side of the human brain. In some cases, as in after stroke, it may increase Ki67 and MAP2. It also aids in the improvement of BDNF, GDNF, and VEGF. Likewise, noted activities are seen on the Skp, Cullin, F-box containing complex.
Benefits & Effects
1. Improving depression
Destruction of the hippocampus is a common pathology in Major Depressive Disorder (MDD). NSI-189 may effectively treat MDD as well as other psychiatric disorders by increasing neurogenesis (growth) in the hippocampus, the part of the brain responsible for emotion, learning, and memory. In a placebo-controlled study, taking 40 mg to 80 mg per day of NSI 189 for 28 days showed significant improvements to depression symptoms in several people.
2. Improving cognition
It may improve cognition and can improve Long-Term Potentiation (LTP).
The same phase I and II clinical trials that studied depression also found potential benefits to cognition.
Self-reported improvements in cognition were reported by those under the phase I trial. This includes not only memory but also learning ability and focus.
Similarly, in the phase II trial of 220 people, the 40 mg dose was also associated with self-reported improvements in cognition, including improvements to memory, working memory, and executive function.
3. May help with ischemic stroke
According to the studies on animals, NSI-189 may improve motor function and hippocampal deficits seen in oxygen-deficit (hypoxia) stroke.
One reason for this is by NSI-189's ability to significantly increase the neurotrophic factors VEGF, BDNF, GDNF, and SCF.
In a rat study, researchers gave rats NSI-189 starting 6 hours after an induced stroke, which was continued daily for 12 weeks. NSI-189 treatment continually helped improve deficits in these mice, even after cessation of the drug. There were significant improvements in brain and motor deficits.
Cell studies show that NSI-189 may reverse cell death processes caused by oxygen deprivation, similar to injury caused by stroke.
4. Helping with diabetic neuropathy
Diabetic neuropathy is a form of nerve damage that can occur in those with diabetes. There's some evidence that NSI-189 may protect and regenerate these damaged nerves from toxicity in diabetes. It may help with nerve pain and neuropathy in diabetes.
A study in rat cells suggests that NSI-189 may promote the growth of sensory neurons. Researchers also found that NSI-189 may stop the progression of nerve damage in both the brain and in the limbs.
5. Potential Treatment for Angelman syndrome
Angelman syndrome is a genetic disorder that primarily affects the nervous system. Symptoms typically include intellectual and developmental disabilities, movement issues, and seizures. The nervous system is the most affected part of the body because of Angelman syndrome. NSI 189 can activate TrkB and Akt pathways and reverses such impairments.
In a mouse study, NSI-189 injections reversed cognitive and movement impairments. Researchers suggest that by activating TrkB and Akt pathways, NSI-189 may represent a potential treatment for Angelman Syndrome patients.
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FAQ
1. How to contact Xi'an Sonwu supplier and inquire products?
You can contact us by email, telephone number and social media.
2. How to ensure the product's quality before order?
Each batch of products need to be tested, so Xi'an Sonwu can supply COA for customers. Additionally, our product have passed the test: HPLC, UV, GC, TLC etc., and Xi'an Sonwu also cooperate with the third parties, like SGS.
3. How to pack and store NSI-189 phosphate?
Pack: Sealed export grade drum and vacuum sealed foil packaging, or we can pack the goods according to customers' need.
Storage: Please store them in cool & dry place. Keep away from strong light and heat.
If you're interested, please contact with Xi'an Sonwu Biotech Co., Ltd.
Email: sales@sonwu.com
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