J147 Powder

Introduction

J147 powder is a curcumin and Cyclohexyl-Bisphenol A (CBA) derivative that is a potent neurogenic and neuroprotective drug. It was developed for the use of treating neurodegenerative conditions associated with aging. Curcumin is a polyphenol and the active component of turmeric and ginger and has many proven benefits in treating numerous diseases, but due to its poor ability to cross the blood-brain barrier(BBB), there are clear limitations. However, J147 can cross the blood-brain barrier into the brain (strong) and induce neuronal stem cell production. Xi'an Sonwu, as a professional manufacturer and supplier in China, can provide high quality products with attractive price. If you need J147, please contact Xi'an Sonwu.

Specification

Functions

1. Improving mitochondria action and longevity

J147 works by binding into the mitochondria, the cells that are responsible for generating energy in our bodies. The action of J147 helps to prevent oxidative stress in mitochondria cells, leading to better cell function and longevity. J147 is very effective in preventing oxidative stress and improving mitochondrial function.

For example, J147 increases mitochondrial function by improving ATP levels (inhibiting ATP synthase, specifically ATP5A). By inhibiting ATP synthase, J147 can reduce toxic metabolites that cause excitotoxicity, the process through which cells die by getting too over excited. This allows for more healthy/younger mitochondria (on a molecular level by modulating the AMPK/mTOR pathway). 

2. Preventing Alzheimer's Disease

According to the related trials, J147 reverses cognitive impairment in a mouse model of Alzheimer's Disease. J147 can improve Amyloid-Beta (Aβ) metabolism and reduce levels in the brain by reducing protein levels of β-Secretase (BACE). In animal models of AD, J147 can protect BBB permeability homeostasis and improve vascular function in the brain. It can also significantly increase levels of Docosahexaenoic Acid (DHA) in the brain. J147 can restore Glutamate levels (synthesized from the TCA intermediate α-ketoglutarate) in the brain. Besides, J-147 curcumin modulates neurotrophin signaling to guarantee neuronal survival, hence, memory formation and cognition.

Patients with AD do have fewer less neurotrophic factors. However, taking J-147 Alzheimer's supplement boosts both NGF and BDNF. These neurotransmitters aid memory formation, learning, and cognitive functions.

3. Improving memory

J147 has also shown a lot of promise among test mouse models in enhancing memory. It enhances memory in both mice with AD and normal aged animal models. Even in very old animal models, J147 can reverse severe cognitive deficits.The drug even helped to reverse severe cognitive deficits in older test subjects during research studies. J147 can also improve spatial memory and enhance Long-Term Potentiation (LTP). 

4. Protecting neurons and helping the brain grow

J147 also has neuroprotective properties that prevent oxidative action within cells. This helps to protect neurons from possible damage. J147 may be a trigger for brain growth. It may also improve synaptic plasticity in the brain, leading to growth. It can prevent neuronal death that is due to oxidative stress. This supplement also blocks the overactivation of NMDA (N-Methyl-D-aspartate) receptors, which is responsible for neurodegeneration. Taking J-147 drug will augment the brain-derived neurotrophic factors (BDNF) and the nerve growth factors (NGF). These two neurotransmitters drive down neurodegenerative diseases such as Alzheimer's and dementia. What's more, BDNF is significant in neurogenesis.

Working principle

J147 powder's effect on the cell remained mysterious until the Salk Institute Neurobiologists decoded the puzzle. The drug works by binding to ATP synthase. ATP synthase, also known as Adenosine Triphosphate Synthase, is a mitochondrial protein that works to help cells generate ATP. ATP is the mitochondrial cell's energy currency. This mitochondrial protein modulates the production of cellular energy, hence, controlling the aging process.

According to researchers, the presence of the J-147 supplement in the human system prevents age-related toxicities that result from dysfunctional mitochondria and overproduction of ATP. It's also found that J147 triggers enhanced production of ATP in the body. The drug may also help to stabilize the mitochondria, a factor that is essential in anti-aging. The significance of these actions is important for one reason. This is because the single biggest cause of Alzheimer's, dementia, and other cognitive ailments is aging. Finding a way to slow down or reverse the effects of aging in the brain could have massive positive effects in treating Alzheimer's.

J147 has also been used to target the buildup of the protein beta-amyloid. High accumulation of this protein in Alzheimer patients has been reported in previous research. J147 aims to remove the beta-amyloid plaque accumulation, which in turn may help reverse or prevent the progression of Alzheimer's and other cognitive issues. 

Factory & Certifications

Shipping & Packaging

Our Advantages

1. Xi'an Sonwu has been engaged in import-export for over 10 years with rich experience in development, research and production of API, plant extract, food additives, and other raw ingredients of health care products.

2. Xi'an Sonwu has a professional team with clear division of labor.

3. Products are tested by third parties.

4. OEM service is available.

Xi'an Sonwu can supply high quality J147 with reasonable price. If you want to buy J147 powder, welcome to contact Xi'an Sonwu.

Email ID: sales@sonwu.com

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