Ethyl Lauroyl Arginate Hydrochloride

Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of ethyl lauroyl arginate hydrochloride in China. We warmly welcome yuo to wholesale bulk ethyl lauroyl arginate hydrochloride for sale here from our factory. Quality products and reasonable price are available.

What Is Ethyl Lauroyl Arginate HCI

Ethyl lauroyl arginate hydrochloride (LAE), (CAS number 60372-77-2), is an antimicrobial compound based on natural building blocks such as lauric acid and L-arginine.

Ethyl lauroyl arginate HCI (LAE) is a synthetic cationic surfactant with antimicrobial properties. It is also known as E-243. It is derived from the reaction of ethyl laurate with arginine, followed by the reaction with hydrochloric acid.

LAE has broad-spectrum antimicrobial activity against bacteria, fungi, and yeasts. Due to its strong antimicrobial properties, it is widely used in the food industry as a preservative and antimicrobial agent to extend the shelf life of food products and inhibit microbial growth.

In addition to its use in the food industry, LAE is also employed in personal care products as a preservative and sanitizing agent. It can be found in oral care products, pharmaceutical formulations, and agricultural applications.

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Where To Buy LAE HCI

Xi'an Sonwu Biotech Co. Ltd. has rich experience in the global trade and health industry. Insisting on faith-based and quality first is our company’s principle. We strictly control product quality, which means selection starts from raw materials. Besides, we handle every detail and reduce the cost to the maximum extent, then our customers can get cost-effective products. Based on these, customers have given much good feedback to our products. So you can look for Xi'an Sonwu Biotech Co. Ltd. when you want to buy LAE HCI.

Xi'an Sonwu completely makes sure of the product’s quality, so samples can be supplied. Here is the quantity.

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Mechanism Of Action

Due to its basic guanidine group, LAE is a cationic surfactant. The target of cationic surfactants is the bacterial cytoplasmic membrane, which carries a negative charge often stabilized by the presence of divalent cations such as Mg2+ and Ca2+. Initially, the cationic surfactant crosses the cell wall (i.e., external cell envelopes) of bacteria. Then, the antimicrobial agent displays a high binding affinity for the outermost surface of the cytoplasmic membrane (i.e., inner cell envelope). Later, the cationic surfactant's alkyl chain penetrates into the membrane's hydrophobic core. This leads to a progressive leakage of cytoplasmic material, perturbating their metabolic processes, and the normal bacterial cycle is inhibited. Thus, cationic surfactants are considered a "membrane-active agent".

Dra. Manresa et al. investigated the effects caused by LAE in Salmonella Typhimurium and Staphylococcus aureus. LAE caused a disturbance in membrane potential and structural changes and loss of cell viability. However, no disruption of cells was detected. Similar effects were also observed on two food-related bacteria such as Yersinia enteroliths and Lactobacillus plantarum. Here, flow cytometry, transmission electron microscopy, and potassium leakage assays demonstrated that LAE targets the cytoplasmic membrane causing loss of membrane potential and potassium ions.

Metabolism And Toxicity Of LAE

According to the in vivo and in vitro studies, LAE is rapidly converted to L-arginine ethyl ester via the cleavage of lauroyl side chain or Nα-lauroyl-L-arginine (LAS) via the loss of ethyl ester. The resulting intermediates are further hydrolyzed to form L-arginine, which is further metabolized to urea and ornithine. Ornithine is further converted to CO2 and urea. Lauric acid is a saturated fat widely found in many vegetable fats and can enter normal fatty acid metabolism. Alcohol can be degraded to CO2 and water via some normal metabolic processes. These data suggest that LAE is primarily and rapidly metabolized in vivo.

The potential toxicity of LAE has been well investigated. Based on two short-term toxicity studies, LAE has no effects on the white blood cells parameters of rats. It has reported that highest dose LAE (15,000 mg/kg feed) had noted effects on the delay (average of 4 days) in vaginal opening in the female offspring. However, the observed delay in vaginal opening is of no long-term toxicological relevance. The research data suggest that LAE has very low mammalian toxicity. More toxicological metabolic investigations are reviewed by Ruckman et al. (2004). The lowest No Observed Adverse Effect Levels (NOAELs) of LAE were 47 and 56 mg/kg body weight (bw) per day for males and females, respectively. The EFSA panel established an acceptable daily intake (ADI) of 0.5 mg/kg bw for LAE. In June 2008, the Joint FAO/WHO Expert Committee on Food Additives (JECFA) established an ADI of 4 mg/kg bw for ethyl-Nα-lauroyl-l-arginate, the active ingredient of LAE.

Indications

Ethyl lauroyl arginate HCI (LAE HCl) has several indications and applications, including:

1. Food preservation: LAE HCl is used as a preservative and antimicrobial agent in various food products. It can help extend the shelf life of meat products, dairy products, juices, seasonings, and more by restraining the growth of bacteria and molds.

2. Oral care products: LAE HCl can be found in toothpaste, mouthwash, and oral sprays due to its antimicrobial properties. It helps prevent oral diseases and infections by restraining the growth of bacteria in the mouth.

3. Personal care products: Remember to wear appropriate personal protective equipment to protect your skin and eyes from direct contact with LAE HCl.

4. Pharmaceuticals: LAE HCl is utilized in pharmaceutical formulations, including topical ointments, eye drops, and emulsions, for its antimicrobial and anti-microbial activities. It can aid in treating skin infections and other related conditions.

It's important to note that LAE HCl should be used in accordance with relevant regulations and guidelines. Additionally, it's essential to conduct appropriate experiments and tests to ensure that the chosen formulation and conditions meet the desired requirements and effectiveness.

Precautions

When working with Ethyl Lauroyl Arginate HCI (LAE HCl), it is important to take the following precautions:

1. Personal protective equipment: Wear appropriate personal protective equipment, such as gloves, safety glasses, and a lab coat, to protect your skin and eyes from direct contact with LAE HCl.

2. Ventilation: Ensure proper ventilation in the working area to minimize exposure to LAE HCl vapors. If working with large quantities or in a confined space, consider using a fume hood or an exhaust system.

3. Storage: Store LAE HCl in a cool, dry place away from incompatible substances. Follow the manufacturer's recommendations for storage conditions and keep it out of reach of children and unauthorized personnel.

4. Handling: Avoid direct contact with LAE HCl. In case of accidental contact, immediately wash the affected area with plenty of water. If it comes into contact with eyes, rinse them thoroughly with water for several minutes and seek medical attention if irritation persists.

5. Use in accordance with regulations: Follow all applicable regulations and guidelines when using LAE HCl, including those related to food additives, personal care products, and pharmaceuticals. Ensure compliance with national, and international regulations.

6. Testing and compatibility: Before incorporating LAE HCl into formulations, conduct appropriate tests to ensure compatibility with other ingredients and assess its effectiveness and stability under intended conditions.

7. Health considerations: While LAE HCl is generally considered safe for use, some individuals may be sensitive or allergic to it. If you experience any adverse reactions or discomfort, discontinue use and seek medical advice.

Remember, these precautions are general guidelines, and it is essential to refer to specific safety data sheets and consult with experts or regulatory authorities for comprehensive information regarding the safe handling, storage, and usage of Ethyl Lauroyl Arginate Hydrochloride.

Difference Between Arginine & Arginine HCI

Arginine and arginine hydrochloride are essentially the same compound with a slight difference in their chemical form.

Arginine is an amino acid, often referred to as L-arginine, that is naturally found in various foods and is also synthesized by the human body. It plays crucial roles in protein synthesis, wound healing, immune function, and hormone production. Arginine is widely used as a dietary supplement for its health benefits, such as promoting cardiovascular health, supporting athletic performance, and enhancing immune function.

Arginine hydrochloride is the hydrochloric acid salt form of arginine. It is produced by adding hydrochloric acid to arginine. The addition of hydrochloric acid results in the formation of arginine hydrochloride crystals or powder, making it more stable and soluble in water compared to pure arginine.

The main practical difference between arginine and arginine hydrochloride lies in their physical properties and solubility. Arginine hydrochloride is commonly used in pharmaceutical formulations, research, and other applications where the salt form provides better stability and solubility characteristics.

In terms of physiological effects, arginine and arginine hydrochloride are considered to be bioequivalent since arginine hydrochloride dissociates into arginine and chloride ions in the body. Therefore, the choice between using arginine or arginine hydrochloride depends on the specific application and formulation requirements.

Interactions

There is limited information available on specific interactions of Ethyl Lauroyl Arginate HCI (LAE HCl) with other substances. However, it is generally considered safe for use in various applications. Nevertheless, some general considerations regarding interactions can be taken into account:

Compatibility with formulation ingredients: LAE HCl should be tested for compatibility with other ingredients in the formulation to ensure stability and effectiveness. Consult with a formulator or follow guidelines provided by the manufacturer to assess compatibility.

pH sensitivity: LAE HCl is most effective in a slightly acidic to neutral pH range. Extreme pH conditions may affect its antimicrobial activity. Therefore, consider the pH requirements of your formulation or product when using LAE HCl.

Sensitivity to anionic surfactants: There is a potential interaction between LAE HCl and anionic surfactants, which can reduce its effectiveness. It is advisable to avoid or minimize the use of anionic surfactants in formulations containing LAE HCl.

Regulatory considerations: Ensure compliance with relevant regulations and guidelines for the specific application of LAE HCl, such as food additives, personal care products, or pharmaceuticals. Always check the permissible usage levels and any restrictions imposed by regulatory authorities.

It is important to note that these are general considerations, and for specific formulations or applications, it is recommended to consult with experts, perform compatibility tests, and refer to available literature or resources to assess any potential interactions of LAE HCl with other substances.

The Collocation Of LAE HCI

Ethyl lauroyl arginate HCI (LAE) can be used in combination with various ingredients depending on the specific application or product formulation. However, it is important to note that LAE is known to have incompatibilities with certain types of ingredients, such as anionic surfactants and certain metal ions. Its efficacy and stability may be affected by these interactions. Here are some examples of ingredients that are commonly used together with LAE in different applications:

1. Food products: LAE can be used with a wide range of food ingredients, including proteins, carbohydrates, oils, and fats. It is often used in conjunction with other preservatives and antioxidants to enhance the overall antimicrobial effectiveness and shelf life of food products.

2. Personal care products: LAE can be incorporated into various personal care formulations, such as shampoos, body washes, mouthwashes, and creams. It can be used with compatible surfactants, emulsifiers, thickeners, and other ingredients commonly found in cosmetic and personal care products.

3. Pharmaceutical formulations: LAE may be included in pharmaceutical preparations, such as topical creams, ointments, and oral care products. It can be combined with compatible excipients, emulsifiers, and active pharmaceutical ingredients (APIs) based on the specific formulation requirements.

When formulating products with LAE, it is advisable to conduct compatibility tests and seek guidance from experts or suppliers to ensure the stability and efficacy of the final product.

Factory

1. Xi'an Sonwu has a factory with sufficient stock. In addition, Xi'an Sonwu has a clean and tidy production department with advanced equipment. Under the company's leadership, researchers continue to develop new products to meet customers' needs.

2. Xi'an Sonwu has advanced testing equipment and professional testing personnel, all of which show that Xi'an Sonwu aims to provide accurate and effective data and good service.

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Logistics Update

In addition to guaranteeing product quality, the other most vital thing is clients could receive the goods smoothly. So, Xi’an Sonwu supplies all kinds of couriers according to different needs.

FAQ

1. How to contact Xi'an Sonwu Biotech Co., Ltd.?

You can contact me by email, telephone number, or social media.

2. How to make sure the quality of the product?

We test each batch, so can supply COA for customers. Besides, our products pass the test: HPLC, UV, GC, TLC, etc. And we also cooperate with third parties, like, SGS.

3. How to pack and store?

Pack: Vacuum sealed foil packaging & Sealed export-grade drum or pack according to customers' needs.

Storage: keep it in a dry and cool place, and make it avoid strong light and heat.

And if you want to know the Ethyl lauroyl arginate hydrochloride price, please contact Xi'an Sonwu.

Email: sales@sonwu.com

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