7,8-Dihydroxyflavone 7,8-DHF

Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of 7,8-dihydroxyflavone 7,8-dhf in China. We warmly welcome yuo to wholesale bulk 7,8-dihydroxyflavone 7,8-dhf for sale here from our factory. Quality products and reasonable price are available.

Where Does 7,8-DHF Come From

7,8-Dihydroxyflavone 7,8-DHF is a kind of flavonoid, a phenolic compound based on the benzochromone ring. When the 7,8-position group in the benzo chromone ring 13a is a hydroxyl group, 7,8-DHF is obtained. 7, 8-DHF is mainly found in foods such as red wine, citrus, cereals, tea, vegetables, and chocolate. Recent studies have found that it is a potent nerve growth factor tyrosine kinase B receptor (tyrosine kinase receptor B, TrkB) agonist in neurodegenerative diseases (Parkinson's disease, Alzheimer's disease), mood Studies in animal models of conditions such as disorders have found that 7, 8-DHF exerts its neuroprotective effect through TrkB receptors. In vivo, brain-derived neurotrophic factor (brain-derived neurotrophic factor, BDNF) is a natural agonist of the TrkB receptor. Still, because BDNF is challenging to enter the brain tissue through the blood-brain barrier, this makes the application of BDNF as a clinical drug limited. Very restrictive. 7, 8-DHF is the first reported drug that can simulate the effect of BDNF, enter the brain tissue through the blood-brain barrier, and improve various neurodegenerative diseases and other abnormal brain functions. Therefore, 7, 8-DHF has received extensive attention, and its research on neuroprotection has reached the stage of clinical application. If you are interested in raw 7,8-dihydroxyflavone, please get in touch with Xi'an Sonwu online.

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Where To Buy 7,8-Dihydroxyflavone

Xi'an Sonwu Biotech Co. Ltd. is a manufacturer and distributor with more than ten years of experience. It has extensive and stable cooperation with countries worldwide in the Americas, Asia, Europe, and Oceania. Xi'an Sonwu has always insisted on product quality first; serving every customer well and satisfying every customer is Xi'an Sonwu's pursuit. Xi'an Sonwu strictly controls every step, from the selection of raw materials, and pursues high-quality products from all aspects, such as material selection, manufacturing, sample testing, and personnel professionalism. In addition, Xi'an Sonwu strives to handle every detail to minimize costs and allow customers to get products with high-cost performance. Based on these, customers have given good feedback on the product. So if you need nootropics, please get in touch with Xi'an Sonwu.

Xi'an Sonwu ultimately makes sure of the product quality and supplies the samples. Please check the quantity.

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OEM Service

Xi'an Sonwu not only can supply high-quality dihydroxyflavone powder and dihydroxyflavone capsules.

So any customers could customize the capsules they want. And items below can be supplied.

1. Customized capsules shells (size, color, material)

2. Customized bottles(size, color, material, style)

3. Customized packaging(vacuum foil packaging, box, drum)

4. Customized label(paint film, matte film, optical mask)

7 8 Dihydroxyflavone Cardiovascular Benefits

7,8-Dihydroxyflavone 7,8-DHF activates TrkB receptors to produce significant biological effects, which have been found in the research on neurodegenerative diseases, Parkinson's disease and Alzheimer's disease, learning, and memory impairment, emotional disorders, etc., and cause Academic and behavioral changes such as improved learning and memory and anti-depression. Many flavonoids play an essential role in the regulation of cardiovascular function. Many experimental studies at home and abroad have shown that flavonoids are important in relaxing blood vessels and lowering blood pressure. Various flavonoids have been widely used clinically due to their excellent blood pressure lowering, vasodilation, and other Cardiovascular protection functions. For example, quercetin, salvia miltiorrhiza, and puerarin have all been used clinically and achieved good results. 7, 8-DHF, as a flavonoid, has been found to have various functions, but cardiovascular research on this aspect has yet to be reported. So what is the effect of 7, 8-DHF on cardiovascular factors?

Both in vitro and in vitro studies have shown TrkB receptors in human and rat vascular smooth muscle. A rat aortic injury model study found that TrkB receptors were significantly increased at the injury site. In mice knocked out for the TrkB receptor agonist BDNF, intramyocardial arterial endothelial cells were impaired during the early postnatal period, suggesting that BDNF activates endogenous TrkB receptors to participate in microvascular endothelial cell formation. The vasodilation effect of 7, 8-DHF was studied using intact and endothelial vessels, and it was found that 7, 8-DHF has a relaxing impact on both. In intact endothelial vessels, EC50=24umol/L, while in endothelial Vascular EC50=104umol/L. Indicating that the vasodilation effect of 7, 8-DHF partly depends on the endothelium.

1. 7, 8-DHF is not dependent on TrkB receptors

Existing studies have shown that there are TrkB receptors in the blood vessels of humans and rats, so it is first to detect whether 7, 8-DHF has a vasodilator effect and may work through TrkB receptors.

ANA-12 is a newly discovered TrkB receptor-specific antagonist. Its dissociation constant with TrkB is 12 μmol/L at the low-affinity site and ten nmol/L at the high-affinity site. The study of its function found that ANA-12 can inhibit the neurogenesis induced by BDNF at 10nmo/L and ultimately inhibit its effect at a concentration of 10-100umol/L. The results showed that in intact and endothelialized blood vessels, both concentrations of ANA-12 did not affect the vasodilation effect of 7,8-DHF.

2.7, 8-DHF relaxes rat thoracic aortic rings through the NO-cGMP pathway

NO is the most crucial vasodilation factor produced by endothelial cells, produced by the action of eNOS of endothelial cells on L-arginine. NO can diffuse to smooth muscle cells of the vascular wall to activate sGC, make cGMP, and then reduce calcium influx through cGMP-dependent protein kinase G (PKG), and at the same time, increase the uptake of calcium by ATPase on the sarcoplasmic reticulum to relax blood vessels. , PKG can also directly act on the dephosphorylation of contractile proteins to cause vasodilation. In this study, in vascular rings with an intact endothelium, after pretreatment with NOS blocker L-NAME and sGC blocker ODQ, the vasodilation strength of 7, 8-DHF was significantly reduced. It acts on vascular endothelial cells and induces endothelial cells to release the relaxation factor NO through the NOcGMP pathway, causing vasodilation.

3.7, 8-DHF relaxes rat thoracic aortic rings through Ca* signaling pathway

The relaxation and contraction are related to regulating various cell ions, including Ca2+, Nat, Kt, etc. The opening and closing of Ca2+ channels on the vascular smooth muscle cell membrane directly affect the intracellular Ca2+ concentration, thereby regulating the contraction and relaxation of the vascular smooth muscle diastolic effect. The contraction of the vascular smooth muscle depends on the increase of intracellular calcium ion concentration, which mainly includes the influx of extracellular calcium ions and the release of calcium ions in the intracellular endoplasmic reticulum. In this experiment, pre-incubation with 7, 8-DHF inhibited the vasoconstriction induced by PE in calcium-free solution after treatment with calcium-free K-H perfusate. The result indicates that 7, 8-DHF can inhibit intracellular calcium release and extracellular calcium influx through ROCC, inhibiting the increase of intracellular Ca2* concentration and causing vasodilation. The same experiment also confirmed that 7, 8-DHF can inhibit the vasoconstriction induced by high potassium solution.

4.7, 8-DHF is not dependent on the K channel on vascular smooth muscle

There are four different types of K* channels on vascular smooth muscle. When the activity of different types of K channels changes, the membrane potential of vascular smooth muscle cells can change, which further affects VDCC. The mechanism for K channels to participate in the regulation of arterial vasomotor contraction. This study observed the effects of four K* channel blockers, 4-AP, glibenclamide, TEA, and BaCl, on the vasodilation effect of 7,8-DHF. The results showed that the four potassium channel blockers had no significant impact on the vasodilator effect of 7,8-DHF.

Factory

1. Xi'an Sonwu Biotech Co., Ltd has its factory to produce, manufacture and store the products, so have adequate stock. Xi'an Sonwu has a well-ordered, clean, and tidy production department. Under Xi'an Sonwu, researchers can continuously develop high-quality new products.

2. Xi'an Sonwu has strict requirements on personnel allocation from production and testing to sales. To ensure that each product is escorted, rigorous data support and after-sales service are provided.

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Packing

Logistics

Besides guaranteeing the product, the other most important thing is customers can receive the goods smoothly. So, Xi'an Sonwu supplies all kinds of couriers according to different needs.

FAQ

1. The dosage of 7,8-DHF varies according to the purpose.

As a nootropic, 10-50 mg per day is recommended for adults.

The recommended dose for patients treating cognitive dysfunction and neurodegenerative diseases is 10-50 mg.

2. What kind of forms of 7,8-DHF are there?

There are three forms: capsules, pills, powder.

If you want to know a 7,8-Dihydroxyflavone manufacturer, you can contact Xi'an Sonwu. Click the email then you get high-quality 7,8-Dihydroxyflavone 7,8-DHF.

Email: sales@sonwu.com

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