12 high-risk factors that lead to Alzheimer's disease, use love to fight forgetfulness, early prevention and early treatment
Many people will say: Who doesn't forget things when they get older?
But Alzheimer's disease is not about being a fool. It is a common neurodegenerative disease. It has memory loss, confused thinking, and abnormal behavior as its main symptoms. As the disease progresses, patients will gradually lose their ability to take care of themselves. The cause of Alzheimer's disease is not completely clear, but may be related to genetics, environment, lifestyle and other factors. At present, Alzheimer's disease has become one of the public health issues of global concern, and many countries and organizations are actively carrying out research, prevention and treatment work.
Therefore, we must prevent and treat Alzheimer's disease early. Although the mechanism of Alzheimer's disease is not yet clear. However, with long-term epidemiological surveys, 12 high-risk factors for Alzheimer's disease have been identified, namely:
Advanced age, family history, APOE4 gene, obesity, insulin resistance, vascular sclerosis, dyslipidemia, hypertension, traumatic brain injury, Down syndrome, loneliness, depression, and sleep disorders. Among these 12 high-risk factors, we cannot change age and family history, but what we can change are: obesity, insulin resistance and hyperlipidemia. Family members can spend more time with the elderly so that the elderly are no longer lonely. .
Gts-21Nootropics is a novel, small-molecule selective a7 nicotinic acetylcholine receptor agonist.It's also frequentlycalled GTS-21HCL orDMXBA becauseit's actually a 3-2,4-dimethoxybenzylidene anabaseine in chemistry.GTS-21 hasrecently been established as a promising treatment for inflammation.In human clinical trials,GTS-21is demonstrated toenhance memory and cognition activity. So it belongs to the category of nootropics and is currently being extensivelyresearched for treatment of Alzheimer's and Schizophrenia as well as Nicotine dependence.
AD& a7 nAChR
ADstands for Alzheimer's disease, which often begins in old age or pre-senile age with dementia as the main
manifestation.lt is a persistent neurological disorder and the most common cause of dementia.The symptoms are gradually severe cognitive impairment(memory impairment,learning impairment, attention impairment, spatial cognitivefunction, problem-solving impairment),gradually unable to adapt to the society.lts main pathological features are senile plaques (SP) formed by β-amyloid (amyloid-$3 protein,Aβ) aggregation in thecerebral cortex and hippocampus, neurofibrillary tangles(NFT) formed by abnormal aggregation of tau protein, and thedecreased neurons existing in the cerebral cortex and hippocampus.
With the in-depth research, more and more evidences have shown that a7 nAChR may bind to AB1-42 in the brain of ADpatients, resulting in the destruction or blockade of a7 nAChR, or causing the death of cholinergic neurons mediated bya7nAChR, which affects cognition and memory.
Schizophrenia & a7 nAChR
Schizophrenia is a common mentalillness, and its pathogenesis is still not fully understood.At present, most scholarsbelieve that schizophrenia is related to abnormal or imbalanced functional states of human brain dopamine(DA).
serotonin (5-HT) and glutamate(Glu)systems. Cognitive dysfunction is one of the coresymptoms of schizophrenia, and atleast 85% of patients with schizophrenia have persistent and severe cognitive impairment.Thereis evidence that a7 nAChR may play a key role in the pathogenesis of schizophrenia.
Therefore, we use a low-salt and low-fat healthy diet to slow down the occurrence of diabetes and hyperlipidemia and protect our blood vessels. The loving company of family members can reduce the isolation and loneliness of the elderly and reduce the occurrence of depression in the elderly. Families and the elderly often go on outdoor outings, which can not only improve their health through outdoor sports, but also enhance communication and interaction among family members.
To prevent Alzheimer's disease, everyone should remember 8 words: live a healthy life and be accompanied by your family.