Triclabendazole drug
Veterinary triclabendazole powder is one of the products with excellent effects on fasciola flukes and disc flukes in cattle and sheep. It is an ideal drug to kill fasciola hepatica. Fasciola is a type of parasite. Generally speaking, parasites include nematodes, tapeworms, trematodes, schistosomiasis, coccidia, Trypanosoma, provides, trichomonas, etc., and the insecticides used for each type are also different. When using the medication, it is necessary to take rotation medication, shuttle medication, and combined medication according to other kinds of parasites. Pure triclabendazole can be used in combination with levamisole and methotrexate.
What is the mechanism of action of triclabendazole
The insecticidal mechanism of triclabendazole against trematodes has yet to be fully elucidated, and its metabolites, sulfoxide and sulfone, are considered the main active substances. Its insecticidal spectrum is narrow and has only been found to have insecticidal effects on adults and larvae of Fasciola hepatica and Paragonimus. It is ineffective against Clonorchis Sinensis. There are currently two explanations for the insecticidal mechanism of triclabendazole against trematodes:
First, it works mainly by interfering with and inhibiting the structure and function of microtubules in the worm. The experimental results of triclabendazole against Fasciola hepatica showed that the drug has the effect of inhibiting colchicine. This effect means that tubulin is bound, and the release of parasite proteolytic enzymes is strongly inhibited.
Second, the drug's mechanism of action is to inhibit protein synthesis in the worm. Experiments have shown that the chromatin in the nucleus of Fasciola hepatica cells is condensed, the nucleolus disappears, the RNA synthesis decreases, and the ribosome decreases. This result indicated that the differentiation of adult primary spermatogonia was inhibited, thereby preventing the formation of spermatocytes and spermatozoa. The above two mechanisms are independent and interrelated. The drug may mainly act on microtubules in the early stage and primarily inhibit protein synthesis in the later stage.
There are also some experimental results showing that triclabendazole may also affect the metabolism of nucleic acids. Triclabendazole was used in in vivo and in vitro insecticidal experiments on domestic dogs infected with Paragonimus westermani. The parasites' protein and DNA content significantly dropped compared to the control group. This result proves that triclabendazole mainly inhibits and destroys the protein synthesis and metabolism of Paragonimus. Moreover, the experiment also found that triclabendazole had a noticeable destructive effect on the body wall of Paragonimus westermani and the ultrastructure of yolk cells. Scanning and transmission electron microscope observations of Paragonimus parasites killed by triclabendazole in vivo and in vitro in dogs that the drug causes the disappearance of Golgi bodies in cortical and yolk cells of parasites, expansion, and deterioration of endoplasmic reticulum, denaturation of mitochondria, and cell membrane. These all support the explanation that the drug destroys the microtubule system and membrane structure. Whether in vivo or in vitro, triclabendazole had no significant effect on glycogen granules in parasite cells.
Triclabendazole use
Triclabendazole was used at a dose of 50 mg/kg per day for two consecutive days to treat bilateral Paragonimus uteri infection in cotton rats, and the insecticidal rate reached 100%. Using triclabendazole at 10 mg/kg per day for two consecutive days to treat the disease of Paragonimus westermani in domestic dogs, the average insecticidal rate was 98.5%, and there has a significant drop in the surviving worm body. The weight decreased significantly, showing that The medicine has an excellent poisonous effect on Paragonimus westermani. Compared with the control group, the insect cysts number in the lungs of the treatment group and the size of the insect cysts shrunk and hardened; it was black, which was caused by the death and decomposition of the parasites and the gradual absorption by the body. As time goes on after treatment, the cysts continue to shrink or even disappear.
Moreover, many dead eggs can be seen on the pathological section of the insect cyst. Triclabendazole was used to treat rats infected with U. stienzii, the total doses were 300 mg/kg (2 days), 450 mg/kg (3 days), and 600 mg kg (3 days), The killing rate of larvae was 50%, 80%, and 87% respectively. Triclabendazole was used at a dose of 8 mg/kg per day to kill the larvae of Paragonimus westermani in mice for two consecutive days, and the reduction rate was 38.3%.
Triclabendazole dosage
Raw triclabendazole has been widely used in countries all over the world and has excellent effects on ruminants such as cattle, sheep, and goats. Sheep: A low dose of triclabendazole (even as low as 2.5 mg/kg) has an effective rate of 98% to 100% for 12-week-old sheep adults, 5 mg/kg for 10-week-old adults, and 10 mg/kg for sheep To 6～8 week age worm body, 12.5 mg/kg is to 1～4 week age immature worm body, 15 mg/kg is nearly 100% to 1 day age worm body effective rate.
Cattle: The effect of triclabendazole on repelling Fasciola hepatica of livestock is similar to that of sheep. The effective rate of 6 mg/kg is 95%~99.5% for 8-14 week-old adults; 12 mg/kg is 79% and 87%, respectively, for 2-week-old, 4-week-old, and 8-week-old adults, 99.4%. The effect of 12 mg/kg on adult worms of Fasciola bovis is similar to that of Fasciola hepatica.
Others: 10 mg/kg for Fasciola deer liver and fasciola large.
12 mg/kg is also effective against Fasciola horse liver.
Triclabendazole for sale
The toxicity of this product is negligible, and the treatment dose has no response to animals, but it is highly toxic to fish.
The drug should be repeated once after five weeks to treat acute hepatic fascioliasis.
It is forbidden during the milking period.
Also, judging from our company's more than ten years of manufacturer experience. In general, triclabendazole is usually mixed with other veterinary drugs. We not can provide you with raw triclabendazole but also offer you other veterinary products. If you need triclabendazole or have additional questions about this product, click the email address, and I will provide a good suggestion or solution for your problem.
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