What Is Another Name For Clotrimazole
API clotrimazole powder may have different commercial or generic names in different countries or regions. Here are some other common names of clotrimazole: Nizoral, Ketoderm, Extina, Fungarest, Kuric, Xolegel, Ketozole, and some other names. It is a broad-spectrum antifungal drug of the azole class. It significantly inhibits Trichophyton rubrum, Trichophyton gypseum, Cryptococcus neoformans, Aspergillus, Algae, Candida albicans, etc. It is a widely used drug for the treatment of fungal infections, commonly used to treat skin infections, vaginal infections, oral infections, etc. It can successfully stop fungal cells from proliferating and growing. It can work by affecting the cell membrane synthesis of fungal cells or interfering with the DNA synthesis of fungal cells. In medicine, it treats various fungal infections, including Candida albicans infections, candidal vaginitis, hand fungal infections, and scalp fungal infections. If you are interested in it, contact Xi'an Sonwu, who can provide raw powder.
Clotrimazole Uses
Vaginal Candidiasis
That is an infection of the female reproductive tract caused by Candida fungi. Common symptoms include vaginal itching, burning sensation, and abnormal vaginal discharge.
Cutaneous Fungal Infections
Cutaneous Fungal Infections include tinea pedis (athlete's foot), tinea manus (tinea manus), tinea corporis (tinea corporis), and Candida albicans infection (Cutaneous Candidiasis), among other conditions.
Oral Candidiasis
That is a Candida infection on the surface of the oral mucosa, common in infants and immunocompromised patients.
Onychomycosis
That is a nail plate fungal infection. Common symptoms include thickening, discoloration, and deformation of the nails.
Vaginal Candida colonization
Some women may carry vaginal Candida without apparent symptoms, but in certain circumstances, such as immunodeficiency and hormonal changes, it may lead to infection.
In addition to the common fungal infections mentioned above, it can also treat other fungal infections. Still, the specific medication should follow the doctor's advice.
What Is The Mechanism Of Action Of Clotrimazole
Clotrimazole is a broad-spectrum antifungal drug used primarily to treat various fungal infections, such as candidal and skin fungal infections. Its mechanism of action involves interfering with the composition and function of fungal cell membranes.
Mechanism of action:
Inhibition of zymosanol synthesis: Its main antifungal effect interferes with zymosanol synthesis in fungal cell membranes. It inhibits the activity of 14α-demethylase, a cytochrome P450 enzyme responsible for catalyzing the critical step in synthesizing zymosanol to ergosterol.
Impact on membrane structure and function: One of the primary constituents of fungal cell membranes, yeast alcohol is necessary to preserve the integrity and functionality of the membrane. The action of it leads to a decrease in the ergosterol content in fungal cell membranes, thereby destroying the structure and function of the membrane. This change in structure and function leads to leakage and disorder of the exchange of substances inside and outside the cell, ultimately leading to the death of fungal cells.
Antioxidative stress: It can also increase oxidative stress in fungal cells, exacerbating the damage of fungal cells by affecting the redox balance in the cells. This antioxidative stress effect helps to enhance the antifungal effect of clotrimazole.
Target:
The main target of it is 14α-demethylase in synthesizing yeast alcohol in fungal cell membranes. That is the critical enzyme for synthesizing ergosterol in fungal cells and catalyzes the conversion of yeast alcohol to ergosterol. This enzyme's activity is inhibited by it, which also prevents ergosterol from being synthesized, modifies the structure and functionality of fungal cell membranes, and eventually kills the fungal cells.
Clotrimazole Interactions
1. Animal experiments have not found that it in this product has the effect of causing pathology and sperm chromosome aberration.
2. Avoid contact with eyes.
3. This product may occasionally cause local skin allergies. Once it occurs, the drug should be discontinued immediately.
4. It is contraindicated for those allergic to this product or other imidazole drugs.
5. It is recommended to avoid treatment during menstruation.
6. Pay attention to personal hygiene during medication to prevent repeated infection.
7. It is contraindicated when the properties of this product change.
8. If an overdose or severe adverse reactions occur, seek medical attention immediately.
9. This product is only for vaginal treatment and should not be taken orally.
For pregnant and lactating women, vaginal administration of it in the last three months of pregnancy has not been found to have adverse effects on the fetus. However, in studies on mice and rats, oral administration of clotrimazole at 50-120 mg/kg body weight can be seen. Embryotoxicity, but no teratogenic effect was found. Therefore, pregnant women should use it with caution.
When lactating women use this product externally, it can be secreted into breast milk, so lactating women should suspend breastfeeding when using this product.
Clotrimazole Dosage Forms
Clotrimazole dosage and duration will differ according to the kind of infection, degree of severity, and individual variances.
For fungal infections of the skin and head, the dose is 200-400 mg per day, taken in 2 divided doses.
For vaginal infections, vaginal suppositories or washes are commonly used.
For oral infections, mouthwashes or topical lotions containing it can be used.
If you want clotrimazole price, are interested in Xi'an Sonwu, or have other questions about the product, do not hesitate to contact Xi'an Sonwu.
Email: sales@sonwu.com