What is Coluracetam (BCI-540)?
Coluracetam powder is also BCI-540 powder, CAS NO is 135463-81-9, Molecular Formula: C19H23N3O3, Molecular Weight: 341.4 g/mol, and a white powder. Its chemical name is N-(2,3-dimethyl-5,6,7,8-tetrahydrofuro[2,3-Chemicalbookb]quinolin-4-yl)-2-(2-oxopyrrolidine)-1-yl)acetamide, is a class of racetam derivatives. Different from racetams, coluracetam increases the rate-limiting step of synaptic choline intake to synthesize the neurotransmitter acetylcholine by participating in the HACU process, and increases the activity of cholinergic neurons to achieve enhanced recognition, then achieving a nootropic effect.
What is Coluracetam Used for?
1.Coluracetam (BCI-540, MKC-231) is a nootropic with cognitive enhancing and neuroprotective properties. It improves memory by promoting the repair of brain cells. BCI-540 can be used to treat memory and intellectual impairment caused by senile dementia, mild to moderate vascular dementia, trauma, and other diseases and to promote the intellectual development of children.
2.It has a significant effect on depression by promoting the transmission of nerve signals. In a phase 2A clinical trial of coluracetam, administered at a dose of 80 mg three times a day for six weeks, coluracetam improved the anxiety scale data in patients with depression and anxiety after six weeks, which proved that this dose Taking coluracetam is effective for depression and anxiety disorders.
3.In degenerative retinal diseases, coluracetam promotes nerve growth. Some users claim that coluracetam can enhance color vision, shape recognition, and optical vividness, which means it has a very good effect on improving human vision. Users describe the effect of enhancing color vision, shape recognition, and optical vividness as "high-definition vision," while others say it brightens lights and enhances contrast.
How is Work?
In experiments studying the hippocampus of bulk coluracetam, the consumption of AF64A in the hippocampus was reduced at doses of 0.3 mg/kg and 1 mg/kg. The experimenters also observed that Coluracetam made up for the lack of neurochemicals. Following the administration of Coluraracetam, hippocampal high-affinity choline uptake (HACU) concentrations are reduced, and high-potassium stimulation-induced acetylcholine (ACh) release can be restored to normal levels.
The mechanism of action of coluracetam can be considered in two ways to achieve the effect. The first and most important one, it does this by selectively affecting memory by enhancing affinity for choline uptake (HACU). Under normal circumstances, racetams mainly trigger the occurrence of acetylcholine by stimulating receptors, while coluracetam increases the level of the neurotransmitter acetylcholine by increasing the affinity of choline uptake to provide more choline. Affinity choline uptake is the rate-limiting step in the synthesis of acetylcholine (ACh), the neurotransmitter most closely associated with memory and cognition. Under the action of coluracetam, the speed at which choline is inhaled into nerve cells in the human body is increased, and the level of the accompanying high-affinity choline transporter molecule CHT1 is increased so that the absorption speed and level of acetylcholine are increased. The higher levels of acetylcholine caused by these combined actions enhance memory and cognition. Coluracetam's effect on the behavior of acetylcholine is thought to be the main reason for acting as a nootropic supplement.
Studies have also shown that rats exposed to choline neurotoxins have improved learning ability after a single dose of coluracetam. Coluracetam can also induce long-term cognitive effects in rats by altering the choline transporter regulatory system.
The second coluracetam also appears to have a potentiating effect on AMPA receptors. AMPA receptors mediate synaptic transmission of rapid excitability in the central nervous system, which is involved in the regulation of learning and memory activities. Abnormal numbers and functions of AMPA receptors may contribute to Alzheimer's disease. AMPA receptors act primarily on the brain and central nervous system, improving brain alertness and cognition. Coluracetam is a particularly effective nootropic supplement, requiring a much smaller dose than other racetams.
Coluracetam vs Aniracetam
The common nootropics of the racetams mainly include Piracetam, Aniracetam, Nefiracetam, Pramiracetam, Fasoracetam, and Oxiracetam, etc. But comparisons are often made between coluracetam and aniracetam.
As coluracetam and aniracetam, which belong to the same class of nootropics, both have the advantages of significant curative effects and extremely low toxicity. But the difference is that coluracetam enhances memory cognition by enhancing choline affinity, while aniracetam is mediated through the interaction between dopaminergic, cholinergic, and serotonergic systems.
In terms of function, coluracetam mainly promotes the repair of brain cells and improves memory; while aniracetam improves memory, brain function, treatment of Alzheimer's disease, learning ability, and improves concentration. Those two products Xi'an Sonwu can offer you powder and capsules,if you want to get coluracetam price, just contact Xi'an Sonwu.
Coluracetam Use
Coluracetam can be taken as pure Coluracetam powder,capsules, or in blended formulations with other nootropics. Like other racetam nootropics, coluracetam can be mixed with alpha GPC to enhance memory and cognition; it can also be mixed with CDP.
For coluracetam powder, Xi'an Sonwu can offer powder and capslues, If you want to buy coluracetam, or have other questions about the product, if you have any questions, please click on the mail, I will provide good suggestions or solve your problems.
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