Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of streptozocin powder in China. We warmly welcome yuo to wholesale bulk streptozocin powder for sale here from our factory. Quality products and reasonable price are available.
What Is Streptozocin
Streptozocin Powder is a chemical compound that is commonly used in scientific research and medical applications. It is derived from a natural product produced by Streptomyces achromogenes bacteria. Streptozotocin is an antibiotic and alkylating agent that is used in medical and research settings. It is primarily known for its cytotoxic (cell-killing) properties and is used in laboratory experiments to induce diabetes mellitus in animal models for studying diabetes and its complications.
It works by damaging the DNA and messing up the normal functioning of cells, especially the beta cells in the pancreas that make insulin. By selectively targeting and damaging these cells, streptozotocin can induce a state of diabetes-like symptoms in animal models. This makes it a valuable tool in diabetes research.
In addition to its research applications, Streptozocin has also been used as a chemotherapeutic agent for treating certain types of cancer, including pancreatic islet cell carcinoma. It is administered through injection, typically intravenously, for medical purposes. As with any medication or research chemical, it is important to handle Streptozocin with care, following proper safety protocols and guidelines.
COA
|
Analysis |
Specification |
Result |
|
Aρpearance |
White to Pale yellow Powder |
Conforms |
|
Odor |
Characteristic |
Conforms |
|
Sulphate ash |
＜0.5% determined on 10g |
0.009% |
|
Assay |
≥99% |
99.5% |
|
Water |
≤1.0% |
0.10% |
|
Loss on drying |
≤2.0% |
0.19% |
|
Related substances |
Unsoecified impurities: for each impurity ＜0.10% |
＜0.10% |
|
|
Total impurity＜0.5% |
0.18% |
|
Heavy Metals |
≤10ppm |
Conforms |
|
Total Plate Count |
≤1000cfu/g |
Conforms |
|
Conclusion |
Conforming to Enterprise Standard |
|
Streptozotocin Supplement
Xi'an Sonwu Biotech Co. Ltd. has rich experience in the global trade and health industry. Insisting on faith-based and quality first is our company’s principle. We strictly control product quality, which means selection starts from raw materials. Besides, we handle every detail and reduce the cost to the maximum extent, then our customers can get cost-effective products. Based on these, customers have given much good feedback to our products. So you can look for Xi'an Sonwu Biotech Co. Ltd. when you need Streptozotocin Supplement.
Xi'an Sonwu completely makes sure of the product’s quality, so samples can be supplied. Here is the quantity.
|
Form |
Sample Amount |
The Minimum of Quantity |
|
Powder |
5g |
10g |
Customers’s Good Comment
What Is The Use Of Streptozotocin
It has several uses in medical and research settings. Here are the main applications of it:
1. Research: It is commonly used in laboratory research to induce diabetes in animal models. Streptozocin specifically targets and harms the beta cells in the pancreas that produce insulin. This results in a decrease in insulin production and the emergence of symptoms similar to diabetes. This allows researchers to study the mechanisms of diabetes and explore potential treatments.
2. Chemotherapy: It is used as a chemotherapy drug to treat specific types of cancer, especially pancreatic islet cell carcinoma. It works by harming the DNA of disease cells, restraining their replication and at last causing cell passing. However, it is critical to take note of that streptozotocin is regularly utilized in mix with other chemotherapy drugs for more successful treatment.
3. Medical Uses: In some rare cases, it may be used in a medical setting for specific conditions such as metastatic insulinoma, a type of neuroendocrine tumor that produces excessive amounts of insulin. It can be administered to help control insulin production and manage symptoms in such cases.
It's crucial to remember that Streptozocin Powder should only be used under the guidance of healthcare professionals due to its potential side effects and toxicity.
Mechanism Of Action Of The Streptozotocin
The mechanism of action of it involves its ability to damage DNA and interfere with cellular processes. Here is a breakdown of its mechanism:
1. Alkylation: It contains a highly reactive group called a methylnitrosourea (MNU) moiety. This group allows streptozotocin to alkylate DNA, which means it can add alkyl groups (specifically methyl groups) to the DNA molecule.
2. DNA Damage: The alkylation of DNA by Streptozocin leads to the formation of DNA adducts. These adducts can cause structural changes in the DNA molecule, particularly in the N7 position of guanine bases.
3. DNA Replication and Transcription Errors: The DNA damage caused by streptozotocin can introduce errors during DNA replication and transcription processes. These errors can lead to the generation of faulty proteins and impair cellular functioning.
4. DNA Strand Breaks: The DNA adducts formed by it can result in the activation of DNA repair mechanisms. During this process, the DNA strands may break, inducing breaks in the DNA double helix.
5. Selective Toxicity: Streptozotocin's cytotoxic effects are primarily seen in cells with high glucose uptake, such as insulin-producing beta cells in the pancreas and certain cancer cells. The high expression of glucose transporters in these cells allows it to accumulate and exert its toxic effects.
6. Beta Cell Destruction: In the case of beta cells in the pancreas, it selectively enters these cells through glucose transporters. Once inside the beta cells, it damages their DNA and disrupts cellular processes, ultimately leading to their destruction and a reduction in insulin production.
Understanding the precise details of streptozotocin's mechanism of action can aid in its application in research and clinical settings, allowing for targeted effects on specific cell types or tissues.
The Side Effects Of The Streptozotocin
Streptozotocin, as a potent chemotherapeutic agent and cytotoxic drug, can have several side effects. Here are some common side effects associated with the use of it:
1. Gastrointestinal Effects: Nausea, vomiting, and diarrhea are commonly reported side effects of Streptozocin treatment. These side effects can go from gentle to serious and might be made do with antiemetic drugs or dietary changes.
2. Hematologic Effects: It can affect the bone marrow, prompting a decline in the creation of platelets. This can result in an increased risk of infections, anemia, and bleeding disorders.
3. Renal Toxicity: It can make harm the kidneys, prompting diminished kidney capability and possibly debilitating the body's capacity to discharge side-effects. Regular monitoring of kidney function is important during streptozotocin treatment.
4. Hepatic Effects: It may also affect liver function, resulting in elevated liver enzymes and impaired liver function. Regular liver function tests are typically conducted to monitor any potential hepatic toxicity.
5. Allergic Reactions: In rare cases, it can trigger allergic reactions, which may manifest as rash, itching, swelling, or difficulty breathing. Immediate medical attention should be sought if any signs of an allergic reaction occur.
It's vital to take note of that the particular secondary effects and their seriousness can shift among people and rely upon elements like the dose, term of treatment, and generally soundness of the patient. It is prescribed to talk with a medical care proficient for extensive data about the likely results of streptozotocin in your particular circumstance.
What Should We Notice When Using It
When using Streptozocin, several precautions should be considered to ensure safe and effective usage:
1. Healthcare Professional Supervision: It should only be used under the guidance and supervision of a qualified healthcare professional who is familiar with its proper administration and potential side effects.
2. Cytotoxic Handling: It is a cytotoxic drug, which means it can be harmful if not handled properly. It should be prepared and administered by trained personnel who follow appropriate safety protocols, including the use of personal protective equipment.
3. Diabetes Induction: If it is being used to induce diabetes in animal models, researchers must have a thorough understanding of how to properly administer the drug and the ethical considerations associated with its use.
4. Patient Selection: It is regularly utilized in the therapy of explicit sorts of disease or for research purposes, such as inducing diabetes in animal models. The healthcare professional will consider factors such as the patient's overall health, medical history, and potential risks and benefits before determining if streptozotocin is the appropriate treatment option.
5. Glucose Monitoring: It can cause a decrease in insulin production and subsequent hyperglycemia. In the event that streptozotocin is being utilized to actuate diabetes, standard checking of blood glucose levels is important to evaluate the effect and movement of diabetes.
6. Allergy and Hypersensitivity: Individuals with a known hypersensitivity or allergy to streptozotocin or other alkylating agents should avoid using this drug. Precautions should be taken to inquire about any known allergies before starting treatment.
7. Organ Function Monitoring: It can have adverse effects on kidney and liver function. Regular monitoring of kidney and liver function through blood tests is essential to detect any potential abnormalities or toxic effects.
8. Pregnancy and Lactation: It may pose risks to a developing fetus or breastfed infants. It is vital to examine the likely dangers and advantages with a medical care proficient prior to utilizing streptozotocin during pregnancy or while breastfeeding.
These protections are not careful, and it is pressing to chat with a clinical benefits capable for expansive course planned for the particular's circumstances while considering the use of streptozotocin.
Factory
1. Xi'an Sonwu has a factory with sufficient stock. In addition, Xi'an Sonwu has a clean and tidy production department with advanced equipment. Under the company's leadership, researchers continue to develop new products to meet customers' needs.
2. Xi'an Sonwu has advanced testing equipment and professional testing personnel, all of which show that Xi'an Sonwu aims to provide accurate and effective data and good service.
Certificate
Package
Logistics Update
In addition to guaranteeing product quality, the other most vital thing is clients could receive the goods smoothly. So, Xi’an Sonwu supplies all kinds of couriers according to different needs.
Company's Profile
Xi'an Sonwu Biotech Co., Ltd is a professional Chinese manufacturer and products supplier. It was founded in 2012 and is located in the Hi-Tech Industrial Zone, Xi'an City, Shannxi Province, China. It pays all attention to the development, research, and production of food additives, plants, extract, APl, and other ingredients of health care products. The company supplies five kinds of raw material products: Anti-hair loss Powders, Nootropic, API, Muscle Building products, and Plant Extract. Xi'an Sonwu sincerely believes that the premise of great cooperation is the best service and good quality. So, welcome your inquiry.
And if you want to know the Streptozocin Powder price or you need Streptozotocin Supplement, please contact XI’an Sonwu.
Email: sales@sonwu.com
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