Salcaprozate Sodium Powder

Sodium N-(8-(2-hydroxy benzoyl)amino)caprylate
Salcaprozate sodium powder or (Sodium N-[8-(2-hydroxybenzoyl) amino] caprylate), referred to as SNAC, is a diphosphonate absorption enhancer used to treat gastrointestinal diseases, especially for gastrointestinal diseases caused by diphosphonate malabsorption. It is a small molecule fatty acid derivative that can promote the absorption of drugs in gastrointestinal epithelial cells, effectively addressing the obstacles to the absorption of oral peptide drugs, and has good application prospects. SNAC can improve the permeability of gastrointestinal epithelial cell membranes, which may be related to membrane perturbation, membrane fluidization, changes in the solubility of APIs, or tight junction openings, or it may improve transcellular permeation by increasing its hydrophobic effect through non-covalent bonding with APIs.
It is a synthetic N-acetylated amino acid derivative of amphoteric salicylic acid. It is currently the most advanced intestinal permeation enhancer (PEs) and is widely used as a delivery agent for oral drug preparations. As the most advanced intestinal permeation enhancer (PEs), SNAC can adhere to the gastric mucosa with peptides to promote drug permeation and absorption and is widely used as a delivery agent for oral preparations. Without altering some preparations' chemical form, biological integrity, or pharmacological characteristics, SNAC can create oral administration routes that facilitate oral absorption of particular macromolecules with low bioavailability, such as insulin, heparin, or small molecule medications. As you can see, it is effective and safe, so if you need raw SNAC, Xi'an Sonwu can provide it.

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Where To Buy SNAC
Xi'an Sonwu Biotech Co. Ltd. has more than ten years of industry experience, specializing in producing and selling raw materials. Xi'an Sonwu has established solid and reliable partnerships with countries in America, Asia, Europe, and Oceania. Xi'an Sonwu puts product quality first and strives to provide every customer with high-quality services to meet their needs fully.
Every stage of the production process of Xi'an Sonwu is rigorously regulated, beginning with the careful selection of raw materials. Products of the highest caliber are Xi'an Sonwu's top priority, and the company's dedication to perfection is demonstrated in all facets, including sample testing, manufacturing methods, material selection, and staff professionalism. By meticulously managing every detail, Xi'an Sonwu can minimize costs without compromising quality, ensuring customers receive products of exceptional value.
Xi'an Sonwu is proud of the positive feedback it has received from customers, who have consistently recognized the quality of the products. To further prove product confidence, Xi'an Sonwu will provide samples for you to test.

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What Is The SNAC In Semaglutide
Sodium 8-(2-hydroxybenzamido)octanoate is a drug ingredient, while semaglutide is a peptide drug commonly used to treat type 2 diabetes. The connection between the two is that some Semaglutide products contain sodium 8-(2-hydroxybenzamido)octanoate in their formula as an auxiliary ingredient to improve the absorption of Semaglutide. In this case, sodium 8-(2-hydroxybenzamido)octanoate helps improve the bioavailability of semaglutide, thereby enhancing the drug's efficacy.
Semaglutide (a GLP-1 receptor agonist), GLP-1 is a hormone secreted by the gastrointestinal tract. It is released into the blood after eating and can stimulate insulin secretion, inhibit glucagon secretion, delay gastric emptying, increase satiety, etc., lowering blood sugar levels. It can play a dual role in "on-demand" blood sugar reduction and "intelligent" weight loss. With the dual effects of blood sugar reduction and weight loss, liraglutide has become a phenomenal "new star." The combination of liraglutide and SNAC is like a tailor-made one and is so far "unique." Only SNAC and semaglutide were used in the oral GLP-1RA preparation. Semaglutide adds the absorption enhancer SNAC to the original Semeglutide molecule, which can increase the local pH value in the stomach, reduce the degradation of Semeglutide molecules by pepsin, and promote the transcellular transport of Semeglutide to achieve gastric absorption of the molecule. Semaglutide can be quickly absorbed into the blood in the short-term neutral acid-base environment in the organism's stomach, and the blood drug concentration is stable. The bioavailability of semaglutide is significantly increased.

Salcaprozate Sodium Uses
Salcaprozate sodium powder is a compound used as an absorption enhancer in pharmaceutical formulations. It is essential for enhancing the transport of several chemicals across biological barriers, including the intestinal mucosa, as it is an absorption enhancer. Its chemical structure and properties allow it to interact with cell membranes and modulate their permeability. SNAC's ability to enhance absorption provides a valuable tool for improving the effectiveness of various drugs, especially those with poor oral bioavailability. Its use is not limited to specific therapeutic classes and has been used in formulations for multiple conditions and diseases. Research and clinical investigations involving SNAC have focused on optimizing drug delivery, especially for drugs with poor solubility or limited absorption. Studies on how to better administer different medicinal agents, like peptides, proteins, and tiny molecules, are included in this.
Medications that the intestines cannot adequately absorb
For drugs that are absorbed inefficiently after oral administration, salcaprozate sodium can help improve their bioavailability, thereby enhancing their therapeutic effects.

Products for the treatment of gastrointestinal disorders
Salcaprozate sodium can be used with drugs that treat gastrointestinal disorders to promote the absorption of these drugs in the intestine and improve their effectiveness.

Peptide Drug Formulations
For peptide drugs, salcaprozate sodium may be used as an absorption enhancer to help these drugs be more efficiently absorbed into the circulation.

How Does SNAC Work
Salcaprozate sodium works through a multifaceted mechanism, primarily enhancing drug absorption within the gastrointestinal tract. Its primary mode of action involves the modulation of intercellular tight junctions, an essential component of the intestinal epithelial barrier. Transient modulation of these tight junctions may increase paracellular transport of co-administered compounds, thereby improving absorption and bioavailability. Its mechanism of action involves interaction with cell membranes, modulation of tight junctions, and enhancement of paracellular transport.
SNAC interacts with the lipid bilayer of cell membranes and may affect membrane fluidity or structure. This interaction may result in a transient change in membrane permeability, thereby facilitating the passage of drugs and therapeutics. Interaction with intercellular tight junctions transiently alters the integrity of these junctions. This modulation creates temporary openings in the paracellular pathway, allowing compounds to pass through the intestinal epithelium. Transient modulation of tight junctions may enhance paracellular transport, allowing co-administered drugs and therapeutics to cross the intercellular space more efficiently. That ultimately results in improved absorption and increased bioavailability of compounds.
Specific Targets:
Intercellular Tight Junctions: Salcaprozate sodium targets the proteins and structures that constitute intercellular tight junctions in the epithelial lining of the gastrointestinal tract. That includes proteins such as occludins, claudins, and junctional adhesion molecules, essential for maintaining tight junction barriers' integrity and selectivity.

Cell Membranes: Salcaprozate sodium interacts with the lipid bilayer of cell membranes, potentially affecting membrane properties and enhancing the permeability of the membranes to co-administered compounds. While the specific molecular interactions involved in this process may vary, the overall effect aims to facilitate the transport of drugs and therapeutic agents across the cell membrane.

Paracellular Transport Processes: Through modulation of tight junctions and interactions with cell membranes, Salcaprozate sodium influences the paracellular transport processes, leading to improved passage of drugs and therapeutic agents across the intestinal epithelium via the intercellular space.

Factory
1. Xi'an Sonwu Biotech Co., Ltd has its factory to produce, manufacture, and store the products, so have adequate stock. Xi'an Sonwu has a well-ordered, clean, and tidy production department. Under Xi'an Sonwu, researchers can continuously develop high-quality new products.
2. Xi'an Sonwu has strict requirements on personnel allocation from production and testing to sales. To ensure that each product is escorted, rigorous data support and after-sales service are provided.

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Besides guaranteeing the product, the other most important thing is customers can receive the goods smoothly. So, Xi'an Sonwu supplies all kinds of couriers according to different needs.


FAQ
In general, sac caprolactone sodium in pharmaceutical formulations follows the following considerations.

Incorporation into Formulations: Saccaprolactone sodium is often incorporated into oral pharmaceutical formulations to enhance the absorption of co-administered compounds. Specific concentrations and formulation details, including dosage form (e.g., tablet, capsule, suspension), are determined by pharmaceutical scientists and may vary based on the intended application and pharmacokinetic considerations.

Use in Specific Drug Products: Saccaprolactone sodium may be included in specific drug products designed to address absorption challenges, such as drugs with poor oral bioavailability or in formulations designed to improve gastrointestinal absorption.
If you want to know the SNAC manufacturer, you can contact Xi'an Sonwu. Click the email, and then you get high-quality salcaprozate sodium powder.
Email: sales@sonwu.com

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