Alpha Ketoglutarate Powder

What Is AKG

Alpha-ketoglutarate powder is a crucial metabolite in various biological processes. It is an organic compound that is an essential intermediate in several metabolic pathways.

Chemically, alpha-ketoglutarate is a keto acid with a molecular formula of C5H6O5. It is structurally derived from glutamic acid, an amino acid commonly found in proteins. Alpha-ketoglutarate is central to cellular energy production and serves as a precursor for synthesizing other essential molecules.

One of the primary functions of alpha-ketoglutarate is its involvement in the citric acid cycle, also known as the Krebs cycle or the tricarboxylic acid (TCA) cycle. This cycle is a fundamental metabolic pathway occurring in the mitochondria of cells, and it generates energy in the form of adenosine triphosphate (ATP). Alpha-ketoglutarate enters the cycle by reacting with acetyl-CoA to produce citrate, initiating a series of chemical reactions that ultimately have ATP, carbon dioxide, and reduced electron carriers such as NADH and FADH2.

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Where To Buy Alpha-Ketoglutarate

Xi'an Sonwu Biotech Co. ltd. has rich experience in global trade and health industry. Insist on faith-based and quality first is our company’s principle. We strictly control product quality, which means selection starts from raw material. Besides, we handle every detail and reduce cost to the maximum extent, then our customers can get cost-effective product. Based on these, customers have given much good feedback to our products. So look for Xi'an Sonwu Biotech Co. ltd. when you need it.

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Xi'an Sonwu not only can supply high quality alpha-ketoglutarate powder, but also supply capsules.

So any customers could customize capsules they want. And items below can be supplied.

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What Is The Role of Alpha-Ketoglutarate

The role of alpha-ketoglutarate (AKG) is multifaceted and plays a crucial role in various biological processes. Here are some of its essential functions:

1. Energy Production: AKG is a vital participant in the citric acid cycle, known as the Krebs or TCA cycles. It serves as an intermediate in this metabolic pathway, where it undergoes a series of reactions to produce ATP, the primary energy currency of cells. By contributing to ATP synthesis, AKG plays a critical role in cellular energy production.

2. Amino Acid Metabolism: AKG is involved in amino acid metabolism, serving as a co-substrate for transaminase enzymes. Transaminases transfer amino groups between molecules, facilitating the synthesis and breakdown of amino acids. AKG helps convert certain amino acids, such as glutamate and glutamine and contributes to the body's overall regulation of nitrogen balance.

3. Precursor for Biosynthesis: AKG serves as a precursor for the biosynthesis of various essential molecules. It can be converted into other metabolites, such as glutamate, a key neurotransmitter in the central nervous system. AKG also participates in the biosynthesis of nucleotides, the building blocks of DNA and RNA.

4. Antioxidant Defense: AKG has been found to possess antioxidant properties. It helps maintain the balance of reactive oxygen species (ROS) in cells by replenishing their antioxidant defense systems. AKG contributes to the production of reduced glutathione, an important antioxidant molecule that protects cells from oxidative stress.

Regulation of Gene Expression: Emerging research suggests that AKG may regulate gene expression. It has been shown to influence the activity of certain enzymes called histone demethylases, which modify histone proteins associated with DNA. By modulating histone demethylase activity, AKG can impact gene expression patterns in various cellular processes.

What Are The Natural Sources of Alpha-Ketoglutarate

Alpha-ketoglutarate is found naturally in various foods, including:

1. Animal products: Meat, fish, eggs, and dairy products are good sources of alpha-ketoglutarate. For example, chicken and pork contain approximately 200-300 mg of alpha-ketoglutarate per 100 g serving.

2. Plant-based foods: Some vegetables also contain alpha-ketoglutarate. Rich sources include cruciferous vegetables like broccoli, cauliflower, kale, spinach, and tomatoes.

3. Fermented foods: Some fermented foods, such as miso, sauerkraut, and kimchi, contain alpha-ketoglutarate due to the fermentation process.

Supplements: As a dietary supplement, alpha-ketoglutarate is available in capsule or powder form. It is sometimes marketed as a sports performance enhancer, but more research is needed to understand its effectiveness and safety for this purpose.

Alpha Ketoglutarate Mechanism

Alpha-ketoglutarate (AKG) is involved in various biological mechanisms due to its versatile nature as a metabolic intermediate. Here, I will discuss some critical mechanisms in which AKG plays a role.

1. Energy Production: AKG is a crucial participant in the citric acid cycle, also known as the Krebs cycle or the tricarboxylic acid (TCA) cycle. In this cycle, AKG reacts with acetyl-CoA to form citrate, initiating a series of enzymatic reactions that produce ATP. As a result, AKG contributes to cellular energy production and is essential for maintaining overall metabolic function.

2. Amino Acid Metabolism: Through transamination reactions, AKG is involved in amino acid metabolism. Transaminases transfer amino groups between molecules, and AKG is a co-substrate in these reactions. It accepts amino groups from various amino acids, generating glutamate and enabling the synthesis of nonessential amino acids like glutamine, proline, and arginine. Additionally, AKG participates in the breakdown of specific amino acids, aiding in nitrogen balance and the urea cycle.

3. Nitric Oxide Generation: AKG is associated with enhancing body nitric oxide (NO) production. NO is a signaling molecule involved in various physiological processes, including vasodilation and immune response. AKG has been suggested to promote NO synthesis by supporting the activity of nitric oxide synthase (NOS) enzymes, which convert L-arginine into NO and citrulline.

4. Antioxidant Defense: AKG exhibits antioxidant properties and contributes to the cellular antioxidant defense system. It helps replenish reduced glutathione, a key antioxidant molecule, by providing precursor molecules. AKG supports reduced glutathione regeneration, which is critical in reducing oxidative stress and protecting cells from free radicals and reactive oxygen species.

5. Epigenetic Regulation: Emerging research suggests that AKG may modulate epigenetic processes, which regulate gene expression without altering the DNA sequence. AKG can influence the activity of histone demethylases, enzymes involved in modifying histone proteins associated with DNA. AKG may impact gene expression patterns and contribute to various cellular processes by affecting histone demethylation.

6. Neurotransmitter Synthesis: AKG is a precursor for synthesizing glutamate, a key neurotransmitter in the central nervous system. Glutamate involves numerous brain functions, including learning, memory, and excitatory signaling between neurons. AKG contributes to the availability of glutamate by participating in its biosynthesis.

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Why Choose Us

Our company has been engaged in import-export for over 10 years and has rich experience in import and export industry.

Our company has 10-year experience in product development, production and sales.

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