Pazopanib Hydrochloride

Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of pazopanib hydrochloride in China. We warmly welcome yuo to wholesale bulk pazopanib hydrochloride for sale here from our factory. Quality products and reasonable price are available.

Pazopanib Votrient

Pazopanib hydrochloride is also known as votrient HCl; pazopanib HCl; CS-462; ArMala; GW-786034B; GW786034 HCl; Unii-33Y9anm545. It is an oral angiogenesis inhibitor targeting VEGFR and PDGFR. Pazopanib is a multikinase inhibitor active against vascular endothelial growth factor receptors 1, -2, and -3. Pazopanib treatment is often associated with transient elevations in serum transaminases during therapy. It has been associated with rare but occasionally severe and even fatal cases of clinically apparent acute liver injury.

The following route synthesizes pazopanib generally available on the market:

Effects of 3-methyl-6-nitroimidazole on trimethyl oxide fluoroborate, trimethyl orthoformate/boron trifluoride etherate and dimethylsulfate/sulfuric acid alkylating agent Methylation give 2,3-dimethylimidazole analogs. Then 2,3-dimethyl-6-nitroimidazole is reduced under stannous chloride and hydrochloric acid to obtain aminoindazole derivatives, and this intermediate is concentrated under the action of 2,4-dichloropyrimidine to get pyrimidine aminoindazole azole. Then the arbitrator is methylated under the effort of methyl iodide and cesium carbonate to obtain fluoropyrimidine aminoindazole, and this intermediate is further reacted with 5-amino-2-methylbenzenesulfonamide to accept the final product pazopanib HCL.

Xi'an Sonwu pursues a safer and more effective method to synthesize pure pazopanib HCL. If interested in this product, you can contact Xi'an Sonwu directly.

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Where To Buy Pazopanib

Xi'an Sonwu Biotech Co., Ltd. has rich experience in the global trade and healthcare industry. Xi'an Sonwu strictly controls the color, shape, smell, and other aspects to ensure the production of high-quality products. Xi'an Sonwu strives to do an excellent job in every production link, which means that every step, from the selection of raw materials to the final presentation of the product, is strictly controlled. Xi'an Sonwu pursues to serve every customer well and meet the needs of every customer. Based on these, customers have given good feedback on products and services. So if you need pazopanib, whether it is pazopanib HCL or pazopanib base, please find Xi'an Sonwu Biotech Co., Ltd.

Xi'an Sonwu ultimately makes certain products quality and provides the sample. Here is the quantity.

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What Is Pazopanib Target

1. Inhibition of vascularization

Animal experiments have shown that taking Votrient HCl twice a day at 100mg/kg/day to treat mice for five days can significantly inhibit the degree of vascularization in mice. You will detect the antiangiogenic activity in mice bearing HT29, A375P, and HN5 malignant cells after a standard three-week course of treatment. HN5 and HT29 xenografts responded better at all doses than the A375P model. The A375P model has historically been more resistant to VEGFR-2 inhibitors. No antiproliferative activity was observed with pazopanib below ten μM by antiangiogenic against HT29, HN5, and A375P grown in serum-containing media. No significant effect on mouse body weight was observed, and animals appeared healthy and active throughout the study.

2. A biocompatible multi-target tyrosine kinase receptor inhibitor

The ATP-like part of the Votrient HCl structure can form hydrogen bonds with tyrosine kinase receptors and compete with ATP to bind to intracellular tyrosine kinase receptors, inhibiting ATP-induced activation. Pazopanib can specifically inhibit VEGFR-1/-2/-3, PDGFR-α/β, M-CSF receptor/FMS, and CSFR/c-kit. Inhibition of these targets is less likely to produce drug resistance because the genes of vascular endothelial cells are relatively stable. Secondly, these targets aim mainly at rapidly growing malignant vascular endothelial cells, and normal tissue blood vessels are not easily damaged.

Pazopanib Side Effects

The recommended dosage of Votrient HCL is 200 mg and 400 mg. Avoid using cytochrome P450 3A4 enzyme inhibitors and ketoconazole, ritonavir, and rifampin products simultaneously when taking this drug of Votrient HCL. The most common side effects while taking Votrient HCL are mouth sores, toothache, diarrhea, nausea, vomiting, loss of appetite, etc. Other adverse reactions of taking pazopanib HCL include diarrhea, high blood pressure, hair change, color change, loss of appetite, vomiting, fatigue, weakness, abdominal pain, and headache. In severe cases, it can cause serious liver problems, irregular heartbeat, hypothyroidism, proteinuria, etc. This product is harmful to the fetus, and this drug is contraindicated during pregnancy.

Solution:

1. Cough: You can take Xiuzheng brand honeysuckle granules orally and Yangyin Qingfei.

2. Fever: Prepare antipyretic patches, and it is best to do a blood test to determine whether the fever is caused by inflammation or malignant cells. Use antipyretics if the temperature is above 38.5 degrees. Ibuprofen Sustained-release Capsules can reduce sweating, reduce fever and relieve pain.

3. Neuralgia: You can take pregabalin alone. If the pain is ineffective after taking painkillers alone, you can add gabapentin.

4. Stomach pain, acid reflux, nausea, and vomiting: you can take Daxi and metoclopramide before nausea and vomiting.

5. High blood pressure: Low pressure exceeding 100 will cause significant damage to the cardiovascular and cerebrovascular. Dipine antihypertensive drugs will affect the concentration of targeted medicines, and you can take sartan and puril antihypertensive drugs.

6. Decreased platelet concentration: can lead to anemia and induce serious diseases, such as cardiopulmonary failure. Fresh frozen plasma or cryoprecipitate can be infused.

Please read the above carefully and contact your doctor if necessary.

How Does Pazopanib Work

Pazopanib hydrochloride is a multi-target tyrosine kinase inhibitor that inhibits angiogenesis and is used to treat RCC. Tyrosine kinase is the most common growth factor receptor. Most RCC patients are activated by hypoxia-inducible factor-related transcription due to VHL gene mutation and abnormal growth of malignant cell tissue. This transcriptional activation overexpresses vascular endothelial growth factor, epidermal growth factor, platelet-derived growth factor, transforming growth factor 2α, and activates Raf/MEK/ERK and PI3K/Akt through receptor tyrosine kinase autophosphorylation. The /mTOR pathway makes cells uncontrollably divide, proliferate and transform, stimulates new blood vessels, and promotes the growth and metastasis of malignant cells. Pazopanib can selectively inhibit VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-α, PDGFR-β, and C-2Kit, and can destroy the signal transmission of bad cells by blocking tyrosine kinases, thereby inhibiting Tumor cell proliferation and new blood vessel formation, to achieve the purpose of anti-malignant cells.

Factory

1. Xi’an Sonwu Biotech Co., Ltd has a factory with sufficient inventory. Xi’an Sonwu has a clean and well-equipped production department. Under Xi’an Sonwu, researchers constantly develop the best products to meet customers’ needs.

2. Xi’an Sonwu Biotech Co., Ltd. has advanced testing equipment and professional testing personnel, all of which show that Xi’an Sonwu is committed to providing accurate and effective data and good services.

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Besides guaranteeing the product, the other most important thing is customers can receive the goods smoothly. So, Xi’an Sonwu supplies all kinds of couriers according to different needs.

FAQ

Xi'an Sonwu is a pazopanib hydrochloride supplier with many years of manufacturing and sales experience. If you have any questions about pazopanib, please feel free to contact Xi'an Sonwu.

Email:sales@sonwu.com

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