99% Gefitinib Powder

Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of 99% gefitinib powder in China. We warmly welcome yuo to wholesale bulk 99% gefitinib powder for sale here from our factory. Quality products and reasonable price are available.

Product's Description

99% gefitinib powder, also known as Iressa powder, is a tyrosine kinase inhibitor that can block mutations in the specific epidermal growth factor receptor (EGFR). It is mainly inhibiting epidermal growth factor receptor and EGFR-TK-dependent cell proliferation to work.

Gefitinib is the first epidermal growth factor receptor tyrosinase inhibitor, a commonly used targeted drug in clinical practice. It can inhibit bad cell proliferation, growth, survival, and signaling pathways. Most of these diseases are in the advanced stage when they are diagnosed, in this time, gefitinib can play a significant role. So the demand for gefitinib in the market has also grown. If you want to find a manufacturer that supplies raw gefitinib, you need to contact Xi'an Sonwu.

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Gefitinib Benefits

Gefitinib's primary effect is improving previous chemotherapy for locally advanced or metastatic non-small cell(NSCLC). This most significant effect has been widely proven in numerous clinical trials. General prior chemotherapy mainly refers to platinum and docetaxel. It works quickly, with an average of 8 to 10 days of medication to relieve symptoms. In vivo studies in some animals suggest that Gefitinib can inhibit bad cell growth in human bad cell-derived lines xenografted in nude mice and enhance the anti-bad cell activity of chemotherapy, radiotherapy, and hormone therapy. There are also some nonclinical data, namely in vitro data, that gefitinib may affect the inhibition of cardiac action potential repolarization (e.g., the QT interval).

Gefitinib Side Effects

In some in vitro studies in animals, the investigators investigated the effect of gefitinib on mutation and cleavage assays. Researchers found that feeding female mice 20 mg/kg/day will affect the ovulation and volume of the corpus luteum. Administration of gefitinib during the onset increased the incidence of skeletal incompleteness in rats. Gefitinib and some of its metabolites are excreted into milk in large quantities when rats during lactation.

It can be seen that the dosage of gefitinib needs to be strictly followed by the doctor's instructions. In addition, some allergic reactions can occur with gefitinib. The most common allergic reactions were diarrhea (CTC grade 1), nausea (CTC grade 1 or 2), rash, pruritus, dry skin, and acne, although some patients had more severe allergic reactions that could reach CTC criteria 3 or grade 4.

Adverse events on body systems with gefitinib in descending order of frequency:

Drug Interactions: gefitinib is metabolized by CYP3A4 in vitro. Co-administration of gefitinib with rifampicin in healthy volunteers reduced the mean AUC of gefitinib by 83%. In healthy volunteers, gefitinib was combined with itraconazole combined use, and the mean AUC of gefitinib was increased by 80%. In combination with drugs that can cause a sustained increase in gastric pH ≥5, the mean AUC of gefitinib can be reduced by 47%. If you need to take gefitinib, check with your doctor if it is related to other drug interactions.

Application

Gefitinib is usually a drug used to treat malignant lung terrible cells. Most of the drugs on the market are tablets. Xi'an Sonwu can provide raw materials.

How Does Gefitinib Work?

Gefitinib is mainly mediated by three biotransformation sites identified in CYP3A4, namely metabolism of N-propoxymorpholinyl, demethylation of methoxyl substituent on quinazoline, and halophenyl oxidative defluorination to act on the liver. It can bind to adenosine triphosphate (ATP) in the epidermal growth factor receptor (EGFR) tyrosine kinase, and it was the first selective inhibitor of EGFR tyrosine kinase, also known as Her1 or ErbB-1.

Epidermal growth factor (EGF) is a polypeptide with a relative molecular mass of 6.45×103, which can bind to the epidermal growth factor receptor (EGFR) on the target cell membrane to produce biological effects. EGFR is a tyrosine kinase (TK) type receptor. When it binds to EGF, it can promote the activation of TK in the receptor, resulting in autophosphorylation of receptor tyrosine residues and providing a continuous signal for cell division, Causing cell proliferation and differentiation. EGFR is abundant in human tissues and highly expressed in bad malignant cells. By inhibiting the EGFR tyrosine kinase, the downstream signaling cascade is also inhibited by 99% gefitinib powder, inhibiting malignant cell proliferation.

There have three ways to inhibit harmful cell growth and further deterioration.

1. Compete for the Mg-ATP binding site on the catalytic region of the tyrosine kinase receptor (EGFR-TK), blocking its signal transmission;

2. Inhibit the activation of mitogen-activated protein kinase and promote cell apoptosis;

3. Inhibit bad cell angiogenesis.

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FAQ

1. What is the recommended dosage?

99% gefitinib powder, 250mg per day and take it orally. Or listen to your doctors.

2. What matter need attention?

This drug may cause hepatitis, so please check your liver function regularly when you use the pure gefitinib. Once the side effects get worse, just stop taking.

If you have interest in our product, please feel free to contact us directly.

Email: sales@sonwu.com

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