Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of mk 1775 in China. We warmly welcome yuo to wholesale bulk mk 1775 for sale here from our factory. Quality products and reasonable price are available.
What Is AZD1775
MK-1775 is a compound that belongs to a class of drugs known as checkpoint kinase 1 (CHK1) inhibitors. CHK1 is a protein involved in cell cycle regulation and DNA damage response. By inhibiting CHK1, It can interfere with the proper repair of damaged DNA, which may be beneficial in certain types of cancer treatment. AZD1775 has been primarily studied in combination with chemotherapy or radiation therapy in preclinical and clinical trials. It is believed that combining AZD1775 with standard cancer treatments may enhance their effectiveness by preventing cancer cells from repairing DNA damage, leading to increased cell death and tumor shrinkage.
The specific applications of AZD1775 in cancer therapy are still being investigated, and it may have potential in various types of cancer. However, it is important to note that the use of AZD1775 or any other drug in cancer treatment requires careful evaluation by healthcare professionals and is typically determined on a case-by-case basis. If you have any specific questions about AZD1775 or its potential use in a particular cancer treatment, it is recommended to consult with a medical oncologist or healthcare provider.
Certificate Of Analysis
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Analysis |
Specification |
Result |
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Aρpearance |
White powder |
Conforms |
|
Identification
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1H NMR spectrum of sample corresponds to that of standard preparation |
Conforms |
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Mass spectrum of sample corresponds to that of standard preparation |
Conforms |
|
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The retention time of the major peak in the chromatogram of sample corresponds to that in the chromatogram of standard preparation |
Conforms |
|
|
Assay |
≥98.0% |
99.4% |
|
Residue on ignition |
≤0.1% |
0.07% |
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Loss on drying |
≤1.0% |
0.76% |
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Conclusion |
Conforming to Enterprise Standard |
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MK-1775 Supplement
Xi'an Sonwu Biotech Co. Ltd. has rich experience in the global trade and health industry. Insisting on faith-based and quality first is our company's principle. We strictly control product quality, which means selection starts from raw materials. Besides, we handle every detail and reduce the cost to the maximum extent, then our customers can get cost-effective products. Based on these, customers have given much good feedback to our products. So you can look for Xi'an Sonwu Biotech Co. Ltd. when you need MK-1775 supplement.
Xi'an Sonwu completely makes sure of the product's quality, so samples can be supplied. Here is the quantity.
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Form |
Sample Amount |
The Minimum of Quantity |
|
Powder |
5g |
10g |
Customers' Good Comment
What Is The Mechanism Of Action Of MK 1775
The mechanism of action of AZD1775 involves its inhibition of checkpoint kinase 1 (CHK1), which is a protein engaged with the guideline of the cell cycle and DNA harm reaction. CHK1 plays a crucial role in preventing cell division until DNA damage is repaired.
When cells undergo DNA damage, CHK1 functions as a checkpoint to pause cell cycle progression, allowing time for DNA repair. However, cancer cells often have alterations in their DNA repair mechanisms, allowing them to survive and continue dividing even with damaged DNA. AZD1775 targets this vulnerability.
By inhibiting CHK1, AZD1775 prevents the normal cell cycle delay and halts the DNA repair process. This interference with DNA repair can lead to the accumulation of DNA damage within cancer cells. When these cells attempt to divide with unrepaired DNA, they can experience lethal levels of genomic instability and ultimately undergo cell death.
The inhibition of CHK1 by AZD1775 is thought to enhance the effectiveness of other DNA-damaging cancer treatments, such as chemotherapy or radiation therapy. By preventing DNA repair in cancer cells, AZD1775 can sensitize them to these therapies and potentially improve treatment outcomes. It's important to note that the use of MK-1775 or any other targeted therapy should be under the guidance of healthcare professionals and individualized to each patient's specific condition and circumstances.
What Is The Wee1 Inhibitor MK1775
The Wee1 inhibitor MK1775 is a small molecule inhibitor that targets the protein kinase Wee1. Wee1 is an enzyme involved in cell cycle regulation, specifically the control of the G2 checkpoint. By inhibiting Wee1, MK1775 prevents the phosphorylation and inactivation of cyclin-dependent kinases (CDKs), leading to premature entry into mitosis.
MK1775 has been studied as a potential anti-cancer therapy, as the dysregulation of the cell cycle is a hallmark of cancer cells. By blocking the G2 checkpoint, MK1775 might possibly prompt DNA harm and cell demise in malignant growth cells, while sparing normal cells to some extent. It is important to note that MK1775 is still being scrutinized in preclinical and clinical examinations, and its exact utility and efficacy in cancer treatment is still being determined.
What Is The Mechanism Of AZD1775
The mechanism of AZD1775 (adavosertib), a Wee1 inhibitor, involves its interaction with the protein kinase Wee1 and its effects on the cell cycle. Wee1 is a kinase that plays a crucial role in the G2 checkpoint of the cell cycle, which acts as a quality control mechanism to ensure accurate DNA replication before cell division. Wee1 phosphorylates and inhibits cyclin-dependent kinases (CDKs), specifically CDK1, which allows for cell cycle progression and mitotic entry. By inhibiting Wee1, AZD1775 prevents the phosphorylation and inactivation of CDK1.
This inhibition of Wee1 leads to several important effects:
1. Premature entrance into mitosis: Normally, Wee1-induced inhibition of CDK1 activity causes a delay in the entry of cells into mitosis. Adavosertib's inhibition of Wee1 allows cells to enter mitosis earlier than they would under normal circumstances.
2. Unscheduled DNA replication: The premature entry into mitosis without proper DNA replication can lead to DNA damage. This unscheduled DNA replication puts stress on the DNA, prompting the aggregation of DNA harm and replication blunders.
3. Synthetic lethality: In cancer cells with underlying DNA repair deficiencies, Wee1 inhibition by AZD1775 can induce further DNA damage. These cancer cells are then unable to effectively repair the DNA damage, resulting in cytotoxicity and selective killing of the cancer cells while sparing normal cells to some extent.
The underlying mechanism of AZD1775 is still being studied and its full therapeutic potential, including its combination with other anticancer drugs, is still under investigation.
What Are The Adverse Events Of Adavosertib
Adavosertib, also known as AZD1775, is a small molecule inhibitor of the protein kinase Wee1, which is involved in cell cycle regulation. Adverse events, or side effects, can occur with the use of adavosertib. Some commonly reported adverse events associated with adavosertib include:
1. Gastrointestinal effects: These may include nausea, vomiting, diarrhea, and abdominal pain. It is important to manage these symptoms to ensure the well-being of patients.
2. Hematological effects: Adavosertib may affect blood cell counts. This can include decreases in white blood cells, red blood cells, or platelets. Close monitoring of blood counts is typically done during treatment.
3. Fatigue: Some patients may experience fatigue or tiredness as a side effect of adavosertib. This can impact daily activities and quality of life.
4. Cutaneous effects: Skin-related side effects such as rash or dry skin have been reported in some patients. These can be managed with appropriate supportive care.
5. Cardiac effects: Rarely, adavosertib may lead to cardiac events such as arrhythmias or changes in heart function. Close monitoring of cardiac function is important during treatment.
It is essential to note that this is not an exhaustive list of adverse events, and the specific side effects experienced can vary between individuals. Adavosertib should be used under the guidance of a healthcare professional who can closely monitor for any adverse events and provide appropriate management strategies.
Factory
Xi'an Sonwu production factory is well-equipped, clean, and tidy, with sufficient stock. Under the leadership of the company, researchers insist on developing new products. The following is the testing environment of our laboratory, advanced testing equipment, and professional testers, with a strict attitude to providing valuable data for our products and providing our customers with a quality experience.
Certificate
Package
Logistics Update
In addition to guaranteeing product quality, the other most vital thing is clients could receive the goods smoothly. So, Xi'an Sonwu supplies all kinds of couriers according to different needs.
Why Choose Us
Our company has been engaged in import-export for over 10 years and has rich experience in the import and export industry.
Our company has 10-year experience in product development, production, and sales.
Our company has a professional team with a clear division of labor.
We have professional laboratories and equipment to ensure high-quality products.
Products are tested by third parties.
We provide OEM service.
We provide 7*24 customer service.
And if you want to know the MK-1775 price or you need MK-1775 supplement, please contact XI'an Sonwu.
Email: sales@sonwu.com
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