Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of aicar powder in China. We warmly welcome yuo to wholesale bulk aicar powder for sale here from our factory. Quality products and reasonable price are available.
What Is The Drug AICAR
AICAR Powder (5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside) is an important drug used in the study of cardiac protection and myocardial cell ischemia. Also, it is a substance produced naturally by the body that stimulates AMP-activated protein kinase. This protein regulates metabolism in a variety of ways. AMPK acts as an energy regulator and is activated during exercise or other circumstances that use up cellular energy. As it is a nucleoside analog, it can enter the nucleoside library and significantly increase the level of adenosine during ATP decomposition. Adenosine modulators (ARAs) have been proven to have the potential for treatment and cardiac protection in myocardial ischemia. AMPK, as a pharmaceutical intermediate, has attracted the keen attention of the medical community. Therefore, suppliers have begun to produce the drug. Xi'an Sonwu, a veteran manufacturer, is also making AMPK. If you are interested in this product, please get in touch with Xi'an Songwu online.
Certificate of Analysis
|
ANALYSIS |
SPECIFICATION |
RESULT |
|
Appearance |
White powder |
Conforms |
|
Identification |
Conform to the RT of Standard |
Conforms |
|
Assay |
≥99.0% |
99.6% |
|
pH |
7.0-7.2 |
7.2 |
|
Water content |
≤2.0% |
0.5% |
|
Heavy Metal |
|
|
|
Cadmium(Cd) |
≤0.2ppm |
0.14ppm |
|
Lead(Pb) |
≤0.3ppm |
0.08ppm |
|
Arsenic(As) |
≤0.3ppm |
Conforms |
|
Mercury(Hg) |
Negative |
Conforms |
|
Microbial Limit |
|
|
|
Total microbial count |
≤750CFU/g |
95CFU/g |
|
Fungi |
≤100CFU/g |
29CFU/g |
|
Samonella |
Negative |
Conforms |
|
E. Coli |
Negative |
Conforms |
|
Conclusion |
This product conforms to the specifications. |
|
Where To Buy AICAR
Xi'an Sonwu Biotechnology Co., Ltd. has rich experience in the international trade and health industry. Adhere to the principle of honesty and quality first. We strictly control the quality of products, starting from raw materials. In addition, we deal with every detail of product processing to minimize costs, and then our customers can get cost-effective products. Based on this, customers gave good feedback on our products. Therefore, when purchasing AICAR, please select Xi'an Sonwu Biotechnology Co., Ltd.
Xi'an Sonwu completely makes sure product’s quality, so sample can be supplied. Here is the quantity.
|
Form |
Sample Amount |
The Minimum of Quantity |
|
Powder |
5g |
10g |
|
Bulk Capsules |
200 capsules |
200 capsules |
|
Bottled Capsules |
5 bottles |
5 bottles |
Customers’ Good Comment
OEM Service
Xi'an Sonwu not only can supply pure AICAR powder, but also supply AICAR capsules.
So any customers could customize capsules they want. And items below can be supplied.
1.Customized capsules shells (size, color, material)
2.Customized bottles(size, color, material, style)
3.Customized packaging(vacuum foil packaging, box, drum)
4.Customized label(paint film, matte film, optical mask)
What Is The Mechanism of Action of AICAR
The nucleoside form of AICAR, an analogue of adenosine, enters heart cells to inhibit adenosine kinase and adenosine deaminase. It increases nucleotide resynthesis rate and adenosine monophosphate production only during myocardial ischemia. In cardiomyocytes, academine is phosphorylated into AICAR to activate AMPK without changing nucleotide levels.AICAR can enter the ab initio pathway to synthesize adenosine and inhibit adenosine deaminase, increasing ATP and adenosine levels.
AMP-activated protein kinases(AMPK) are sensors of cellular energy status in all eukaryotic cells and are activated by LKB1-dependent phosphorylation. Recent studies indicate that activated LKB1 induces polarity in epithelial cells, and the formation of tight connective structures accompanies this polarization. Recent research further demonstrated that this protein kinase also contributes to the assembly of fast connections during epithelial cell polarization. Activation of this protein kinase by 5-aminimidazo-4-formamide riboside contributes to tight junction assembly in average extracellular Ca2+ concentrations and initiates quick junction assembly without Ca2+. These results suggest that AMPK plays a role in regulating packed junction assembly.
What Is The Function of AICAR
AICAR stimulates AMP-dependent protein kinase (AMPK) activity. The drug has also been shown to be a potential diabetes treatment by altering the physical composition of muscles to increase the metabolic activity of tissues.
When AMPK is increased, the body kicks into high gear and functions with youthful vitality. Activated AMPK helps remove excess glucose and fats, burning them for energy instead of depositing them in the belly and elsewhere. To support all this increased fat burning, cells manufacture new mitochondria in a process known as mitochondrial biogenesis. These newly created mitochondria burn fuel more cleanly and efficiently than older, worn-out mitochondria, resulting in higher energy output for the entire body.
AMPK-activated cells are generally cleaner, healthier cells. Old cells with decreased AMPK activity tend to become clogged with cellular debris, which reduces their efficiency and shortens their life span. These junk-laden cells accelerate the aging process and contribute to neurodegenerative diseases like Alzheimer’s7 and Parkinson’s,64 and to the thickening and stiffening of vital tissues throughout the body. Cells energized by AMPK empty their internal garbage cans of accumulated damaged proteins and then convert these damaged proteins for recycling into healthy new ones. The result of AMPK re-activation is enhanced efficient cellular activity. Finally, increased AMPK activation can suppress body-wide inflammatory responses such as those produced by excess belly fat. Over the last few years, research has shown that it is possible to revitalize AMPK to youthful activity levels. To date, experiments have shown that increased AMPK activation can have the following effects:
1. Extended life span by as much as 20-30% in animals,
2. Improved glucose uptake in cells, lowering blood sugar.
3. Inhibiting excess fat synthesis and increased burning of stored fat.
4. Reduction of blood triglycerides.
5. Decreased liver fat accumulation and fat-related chronic inflammation. 6.Increased numbers of new, healthy mitochondria.
AICAR Side Effects
Too much activation of AMPK, or activating it in the wrong tissue, can cause serious side effects, including neurodegeneration, or preventing cells from dividing. The accumulation of naturally-occurring AICAR in the body is also associated with metabolic disorders in humans. If you have any questions about the use of this medication, be sure to consult your doctor or professional pharmacist in the first place.
Factory Environment
Certificates
Packaging
In addition to ensuring the quality of the product, it is equally important for the customer to receive the finished product smoothly. Therefore, Xi 'an Songwu will provide corresponding express delivery according to different needs.
Logistics
Why Choose Us
1.Strong Strength
Owning our own producing workshop and OEM factory, and lab.
2. Experienced
Doing export business to all over the world for more than 8 years.
3. Professional team
Having perfect R&, sales and service team.
4. Sincere Service
Having perfect R&,sales and service team.Having been in the industry for many years, the customer praise rate has reached 99%.
5. Customers' review
Having been in the industry for many years, the customer praise rate has reached 99%.
If you want to know the AICAR powder price, please do not hesitate to contact us online.
E-mail :sales@sonwu.com
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