Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of chenodeoxycholic acid powder in China. We warmly welcome yuo to wholesale bulk chenodeoxycholic acid powder for sale here from our factory. Quality products and reasonable price are available.
What Is Chenodeoxycholic Acid?
Chenodeoxycholic acid powder is a white organic matter soluble in ethanol and glacial acetic acid. It can be shortened to CDCA. This powder's primary effect is reducing cholesterol saturation in the bile. When the vast majority of patients take CDCA and CDCA accounts for 70% of bile salts in bitterness, the lipids return to the state of micro granules, and the cholesterol is unsaturated so that the cholesterol in the stones is dissolved and shed. A daily dose of 10mg/kg to 15mg/kg CDCA inhibits cholesterol synthesis and increases bile secretion in patients with cholelithiasis. As a result, CDCA is one of the world's most widely used drugs for gallstones. It is also used to synthesize ursodeoxycholic acid (UDCA) and other steroidal compounds. As a professional producer of CDCA, Xi' an Sonwu is favored by consumers for its high-quality products and excellent service. If you want to purchase, please feel free to contact Xi' an Sonwu.
COA
Where to Buy CDCA？
Xi'an Sonwu Biotech Co. ltd. has rich experience in the global trade and health industry. Insisting on faith-based and quality first is our company's principle. We strictly control product quality, which means selection starts from raw materials. Besides, we handle every detail and reduce the cost to the maximum so our customers can get a cost-effective product. Based on these, customers have given much good feedback to our products. So look for Xi'an Sonwu Biotech Co. ltd. when buying CDCA.
We ensure the product's quality so that samples can be supplied. Here is the quantity.
Sample Amount | The Minimum Quantity |
1kg | 1kg |
Customers' Comment
How Does CDAC Work?
CDCA is synthesized by cholesterol in the liver through several enzymatic steps. Like other BAs, it can combine with taurine or glycine to form taurodeoxycholate or gandeoxycholate. Conjugation results in a lower pKa. This causes the bound bile acids to be ionized in the gut at the normal pH and to remain in the GI tract until they reach the ileum for reabsorption. At the same time, CDCA and other bile acids form micelles that facilitate lipid digestion. After absorption, they are absorbed by the liver and re-secreted, thus carrying out enterohepatic circulation. Bacteria can metabolize unabsorbed CDCA in the colon to form second bile acid, lithic acid, or the differential isomer UDCA.
The Distribution of CDCA In the Human Body
Chenodeoxycholic acid powder is a highly chemically purified unbound cholic acid containing different crystalline forms. Average doses of 500mg to 750mg of CDCA are almost entirely absorbed, whether taken on an empty stomach or with food. A small part of the protein combined with plasma in peripheral blood dissociation maintains a low level. Part of it is discharged into the intestinal cavity through the biliary tract and reabsorbed, forming enterohepatic circulation. The liver takes it up and removes it efficiently. CDCA binds to glycine or taurine in the liver and is secreted in bile. Binding CDcas are absorbable and quickly cleared by the liver. The binding type of CDCA in the gut can be dissociated into the newly ingested bile acid pool. However, unabsorbed drugs were excreted or transformed into UDCA in feces, but most of them were decomposed into LCA after 7α-dehydroxylation by coliform flora. Therefore, LCA is the primary metabolite of oral CDCA.
What Is The Importance of Chenodeoxycholic Acid In Digestion?
CDCA is a naturally existing bile acid in the body. It works by dissolving the cholesterol that causes gallstones and inhibiting cholesterol production in the liver and absorption in the gut, which helps reduce gallstone formation.
What Is Chenodeoxycholic Acid Used for?
CDCA is currently the most important drug for treating gallstones worldwide and is the most used of all gallstone drugs. At the same time, it is also an important raw material for synthesizing UCDA and other steroidal compounds. It is widely used in clinical practice. CDCA can dissolve cholesterol gallstones, which is very effective in treating gallbladder cholesterol gallstones with a diameter of no more than 2cm and good gallbladder function. Not only that, but CDCA can also treat pigmentary stones and mixed stones.
1. Gallstones
CDCA has been used as a medical treatment to dissolve gallstones. Oral BA drug therapy has been used in patients with small cholesterol stones and those with significant cholesterol stones which are unwilling to undergo surgery. In humans, CDCA is a physiological ligand for bile acid sensor farnesene X receptor (FXR), while LCA is a potent agonist for G protein-coupled receptors. Together with UDCA, CDCA has been used clinically to dissolve gallstones in the dose range of 375 to 750 mg/ day with a success rate of 8% to 18%. However, excessive CDCA treatment resulted in diarrhea, mild reversible liver damage, and increased plasma cholesterol levels.
2. Constipation
CDCA has been investigated as a possible treatment for constipation due to its use in frequent diarrhea during gallstone dissolution. And experimental results have shown that it can accelerate colonic transport and improve intestinal function.
3. Cerebrotendineous xanthomatosis
In 2017, CDCA was approved to treat patients with cerebral tendinoxanthomatosis (CTX). The disease is a rare autosomal recessive disorder caused by mutations in the sterol 27-hydroxylase (CYP27A1) gene. Because CYP27A1 is required for cholesterol breakdown, CTX patients experience abnormal lipid storage, elevated plasma and tissue levels of cholesterols, and very low to no CDCA production. However, CDCA is a potent inhibitor of CYP27A1. Early initiation of CDCA therapy with doses up to 750 mg/ day is considered the standard drug therapy for CTX, reducing plasma cholesterol levels and stabilizing neurological symptoms.
How Do You Take Chenodeoxycholic Acid?
CDCA is a common choleretic drug used in the treatment of gallstones. Its primary dosage forms are tablets and capsules. CDCA tablets are prescription drugs and should only be taken under the guidance of a physician. The dosage can be adjusted appropriately according to the situation. The general dosage is according to body weight, 12mg/kg to 15mg/kg daily, divided into two times in the morning and evening. Obese people with large body weights should increase the dose daily by 18mg/kg to 20mg/kg for about 6 months to 24 months. Contact your doctor to confirm the specific dosage. Please take on the advice of your doctor. Do not change the prescription yourself.
Precautions for CDCA
1. CDCA is an oral drug.
2. Other adverse reactions of CDCA include dizziness and nausea.
3. CDCA can inhibit the intestinal absorption of water, so it will easily cause diarrhea symptoms, which usually heal after two weeks.
4. It takes a long time to take it, and it usually takes half a year or even more than a year to have the effect of dissolving stones.
Who Cannot Take CDCA?
1. Children should not take it.
2. Diabetics should not take it either.
3. Pregnant women and lactating women are prohibited from taking it.
4. Patients with chronic liver disease, ulcer disease, enteritis, and renal insufficiency cannot take it.
If there are severe adverse reactions after taking it, stop taking it in time.
What Are The Side Effects of CDCA?
1. Very few patients may have a transient reversible AST (SGOT) increase.
2. Some patients may experience skin itching, dizziness, nausea and vomiting, and abdominal distension.
3. The most common side effect is diarrhea, mainly lower abdominal cramps. This situation is related to the dosage and disappears after the drug is reduced. Most patients can tolerate it if the dosage is gradually increased.
What Should Be Noticed When Taking CDCA?
1. Cholestyramine, Colestipol, and aluminum-containing antacids can all combine with CDCA to reduce their absorption and should not be used together.
2. Birth control pills can increase bile saturation. Other birth control measures should be taken as far as possible when using this product to avoid affecting the curative effect.
Factory Environment
1. Xi'an Sonwu Biotech Co., Ltd has its factory, so it has adequate stock. Also, Xi'an Sonwu has a clean and tidy producing department with advanced equipment. With the lead of Xi'an Sonwu, researchers are constantly developing new products to meet customers' needs.
2. Xi'an Sonwu Biotech Co., Ltd has advanced test equipment and professional testers, which all show that Xi'an Sonwu aims to supply accurate and effective data and good service.
Certificates
Package
The Latest Logistics Records
Besides guaranteeing the product's quality, the other most important thing is customers can receive the goods smoothly. So, Xi'an Sonwu supply all kinds of courier according to different need.
Why Choose us?
Pre-Sales Service：
1. OEM customization service
2. Support sample testing.
3. Enquiries will be answered within 24 hours.
4. Every batch of products is tested to ensure quality.
5. Provide packing list, bill of lading, commercial invoice, COA, and other supporting documents.
After-Sales Service:
1. Update logistics information timely.
2. All products with quality problems can be returned.
3. You can consult Xi'an Sonwu at any time about using the product.
If you need to buy chenodeoxycholic acid powder, you can contact Xi'an Sonwu directly.
E-mail: sales@sonwu.com
Hot Tags: chenodeoxycholic acid powder, China, suppliers, manufacturers, factory, wholesale, buy, price, bulk, pure, raw, supply, for sale, Beta-NMN, Simeticone API, Ribociclib Succinate Powder, Aminophylline API, Monosialoganglioside GM1, Prostaglandin E1 Powder
