Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of brigatinib powder in China. We warmly welcome yuo to wholesale bulk brigatinib powder for sale here from our factory. Quality products and reasonable price are available.
What Is Brigatinib
Brigatinib powder is a novel dual inhibitor of ALK and EGFR, which can potently inhibit the L1196M mutation of ALK and the T790M mutation of EGFR. It is the fourth-generation new drug for treating lung diseases and is another good choice for patients with lung diseases. As a potent ALK/EGFR inhibitor, it can not only inhibit the L1196M mutation of ALK but also has specific effects on T790M double mutation non-small cell lung disease and has a particular impact on C797S/T790M/del19 triple mutant cells and T790M/del19 double mutation Cells are also active. Xi'an Sonwnu provides bulk Brigatinib; if you want to buy them, you can contact Xi'an Sonwnu without hesitation.
COA
Where to Buy Brigatinib
Xi'an Sonwu Biotech Co. ltd, the products produced are strictly controlled in quality from the beginning of the raw material powder. In processing product production, we handle every detail well and enable our customers to get cost-effective products. Many customers have given good feedback to our products after receiving the goods.
To ensure the quality of the products, we can provide samples for testing. Here is the quantity.
|
Form |
MOQ |
Sample |
|
Powder |
10g |
100g |
Customers’s Good Comment
What Are ALK And EGFR
ALK was first discovered in a subtype of anaplastic ALCL, so it was named anaplastic lymphoma kinase, ALK. Subsequently, multiple ALK gene rearrangements were found in diffuse extensive B-cell lymphoid disease and inflammatory myofibroblastic disease (IMT), respectively, before ALK gene rearrangements were found in non-small cell lung disease. So far, it has been proved that ALK is a powerful oncogenic driver gene.
EGFR is called Human Epidermal Growth Factor Receptor in Chinese. It is a growth factor receptor on the surface of human cells. Under normal circumstances, it can bind to growth factors to promote cell growth and reproduction. In necrotic cells, the gene encoding this growth factor receptor is mutated, expressing abnormal growth factor receptors, which enables the development of necrotic cells. Studies have found that EGFR gene mutations can be detected in nearly 50% of patients with non-small cell lung disease in the East Asian population and may be related to the survival, growth, and metastasis of necrotic cells. The detection of EGFR gene mutation has become a must-check item in diagnosing patients with non-small cell lung disease, and targeted therapy drugs for this gene mutation have increasingly become one of the primary methods for treating non-small cell lung disease.
What Is The Use Of Brigatinib Powder
It is understood that Brigatinib has been proven to inhibit ALK and ALK fusion proteins, thereby inhibiting the growth of necrotic cells. In vitro and in vivo tests, brigatinib showed sound inhibitory effects. Therefore, it has also successively obtained the breakthrough therapy designation and orphan drug qualification issued by the US FDA.
In terms of treatment, studies have confirmed that brigatinib can overcome the resistance to crizotinib caused by ALK mutants and has resistance to multiple kinases (including ALK, ROS1, insulin-like growth factor-1 receptor, Flt-3 ) and activity of surface growth factor receptor (EGFR) deletions and point mutations.
What's more worth mentioning is that brigatinib's inhibitory effect on ALK is 12 times higher than that of crizotinib. It has high resistance to ALK mutants, so that it can treat disease progression after crizotinib treatment or Intolerant patients with ALK-positive metastatic non-small cell lung disease. From the results of related research, it is not difficult to find the excellent therapeutic performance of Brigatinib.
What Are The Side Effects Of Brigatinib
1. Signs of allergies: hives; difficulty breathing; swelling of the face, lips, tongue, or throat.
2. Serious side effects:
● Lung problems: Cough, trouble breathing, chest pain, fever.
● Vision problems: blurred vision, double vision.
● Hypertension.
● High blood sugar: Thirst, increased urination, hunger, nausea, fruity breath, weakness, confusion.
● Heart problems.
● Pancreatitis: Pain in the upper abdomen.
3. Common side effects may include hunger, nausea, breath odor, weakness, confusion, muscle pain, muscle weakness, pancreatitis, nausea, and weight loss.
How To Take Brigatinib
1. Recommended dosage for adults with non-small cell lung disease: 90 mg orally per day for the first seven days; if the initial dose is tolerated within the first seven days, then increase to 180 mg orally per day. If the initial dose is not tolerated within the first seven days, take the amount adjusted by the attending physician.
2. Dose adjustment, if the previous dose was 90mg, reduce it to 60mg. If not tolerated, permanently stop the drug if the last dose is 180mg, the first reduction to 120mg, the second reduction to 90mg, the third reduction to 60mg, and the fourth permanent withdrawal.
Please inform your doctor before taking it if you take other medicines and take them according to the doctor's recommended dosage.
What To Watch Out For Before Taking Brigatinib
1. Lung disease or breathing problems;
2. Slow heartbeat;
3. Hypertension;
4. Vision problems;
5. Diabetes or glucose intolerance;
6. Pancreatic problems;
7. Liver disease;
8. Kidney disease;
9. It is forbidden to take during pregnancy or lactation
Brigatinib may interfere with how hormonal birth control pills work, so you must use non-hormonal birth control. Women should use non-hormonal contraception during treatment and for four months after the last dose. Male and female partners should use contraception during treatment and continue to use contraception for three months after the previous dose. Brigatinib may be harmful to the fetus.
Lactating women should not breastfeed during treatment with brigatinib and within one week after treatment.
Factory Environment
1. Xi'an Sonwu Biotech Co., Ltd has a factory with sufficient stock. In addition, the production department of Xi'an Matsuya is very clean and tidy. Using advanced production equipment, researchers continue developing new products to meet customers' needs.
2. Xi'an Sonwu Biotech Co., Ltd has advanced testing equipment and professional testing personnel, which has laid a solid foundation for providing customers with accurate and practical data.
Certificates
Packing
Recent Logistics
Except guarantee the product’s, the other most important thing is customers could receive the goods smoothly. So, Xi’an Sonwu supplies all kinds of courier according to different need.
FAQ
How to pack and store Brigatinib powder?
Packaging: export grade sealed drum, vacuum sealed aluminum foil packaging, can also be packed according to customer needs.
Storage: please store in a cool and dry place to avoid bright light and high temperature.
If you want to buy Brigatinib, feel free to contact Xi'an Sonwu.
E-mail: sales@sonwu.com
Hot Tags: brigatinib powder, China, suppliers, manufacturers, factory, wholesale, buy, price, bulk, pure, raw, supply, for sale, 9 ME BC Powder, Pure Pregabalin Powder, Flibanserin Powder, Fasoracetam Powder, Nicotinic Acid Mononucleotide, Flibanserin Hydrochloride
