Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of baricitinib powder in China. We warmly welcome yuo to wholesale bulk baricitinib powder for sale here from our factory. Quality products and reasonable price are available.
What Is Baricitinib
Baricitinib powder is an inhibitor of JAK kinases 1 and 2, and it has another name, Olumiant. It works by blocking Janus kinase. Baricitinib treats rheumatoid arthritis to relieve joint pain, stiffness, and swelling. It can reduce disease activity for patients with rheumatoid arthritis who have not previously used biologic DMARDS drugs.
What Are JAK Kinases
JAK kinases are intracellular non-receptor tyrosine kinases that mediate cytokine signals and pass them on through the JAK-STAT signaling pathway. The JAK kinase family has four members: JAK kinase 1 (JAK1), JAK kinase 2 (JAK2), JAK kinase 3 (JAK3), and tyrosine kinase 2 (TYK2). JAK1 and JAK2 are involved in type II interferon signaling, while JAK1 and TYK2 are involved in type I interferon signaling, and mice that do not express TYK2 have functional defects in natural killer cells. JAK kinases bind to the proline-rich box1/box2 region of each intramolecular domain adjacent to the cell membrane. When a cytokine receptor binds to its respective cytokine ligand, the two JAK kinases approach each other through a conformational change, allowing them to phosphorylate. The autophosphorylation of JAK kinases also causes conformational changes, enabling them to phosphorylate further and activate transcription factors called STATs for intracellular signal transduction. After the activated STATs leave the receptor and form dimers, they are transferred to the nucleus to regulate the transcription of specific genes.
Xi'an Sonwu is a raw material manufacturer that can provide raw materials with different functions. For products, we can provide raw material powder and customized capsules for products. If you are interested, please feel free to contact Xi'an Sonwnu.
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COA
Where to Buy Baricitinib
Xi'an Sonwu Biotech Co. ltd, the products produced are strictly controlled in quality and have been rigorously screened from the beginning of the raw materials. In the product production process, we handle every detail well, minimize costs, and enable our customers to get cost-effective products. Many customers have given good feedback to our products after receiving the goods.
To ensure the quality of the products, we can provide samples for testing. Here is the quantity.
| Sample Amount | The minimum of Quantity |
| 10g | 100g |
Customers’s Good Comment
What Is the Mechanism of Baricitinib
Baricitinib is a selective JAK2 and JAK1 inhibitor with less potency against JanusKinase, jak3orTYK2. This kinase and its associated signal transducer and activator of transcription (JAK-STAT) are the major intracellular pathways that control the magnitude and duration of cytokine signaling with type I and type II cytokine receptors. These receptors lack intrinsic enzymatic activity that can mediate signal transduction; Janus kinase transducers and activators of transcription activate STAT by phosphorylation of JAK enzymes. IL-6, granulocyte-macrophage colony-stimulating factor (GM-CSF) factor, is involved in the pathogenesis of RA, including IL-6 granulocyte-macrophage colony-stimulating factor (GM-CSF) factor. Interferon signaling through the JAK-STAT signaling pathway. Therefore, JAK1 and JAK2 inhibitors can target multiple RA-related cytokine pathways, thereby reducing the activation and proliferation of inflammatory cells and critical immune cells. Baricitinib did not affect JAK3. JAK3 may be related to joint γ-chain receptors. Common γ chain cytokines include IL-15 and IL-21, which regulate lymphocyte activation, function, and proliferation.
Side Effects
1. Common side effects: nausea; cold sores; stuffy nose, sneezing, sore throat
2. Serious side effects
● Fever, chills, night sweats, persistent tiredness
● Wheezing, trouble to breathe, and coughing incessantly
● Increased frequency and pain during urination, dark urine
● Weight loss
● Lumps on the body, such as in the neck, armpits, or groin
● Have blisters or herpes zoster
● Diarrhea, stomach pain
● Loss of appetite, vomiting, stomach pain, jaundice
Before using the Baricitinib drug, tell your doctor if you are taking other medicines. Use according to the dosage recommended by your doctor. If any adverse side effects occur after taking the medication, stop taking medicine and inform your doctor of the situation.
What to Expect Before Taking Baricitinib
Baricitinib supplements may increase the risk of certain diseases, so know your doctor ahead of time if your body has any of the following:
1. Immune system diseases such as tuberculosis, herpes zoster, HIV, or hepatitis
2. Kidney disease
3. Diverticulitis, stomach or intestinal ulcers
4. Heart problems
5. High cholesterol
6. Signs of infection such as fever, chills, muscle aches, cough, difficulty breathing, skin sores, diarrhea, or painful urination
What Is the Dose of Baricitinib Powder
1. Adults with rheumatoid arthritis take 2 mg once a day. It treats patients with moderately to severely active rheumatoid arthritis caused by TNF.
2. 4 mg once daily for adults with COVID-19
Children with COVID-19:
◆ 2 to under nine years: 2 mg once daily
◆ Age 9+: 4 mg once daily
Taking cycle: take it continuously for 14 days until discharge.
It treats coronavirus patients who need supplemental oxygen or extracorporeal membrane oxygenation.
Factory Environment
1.Xi'an Sonwu Biotech Co.,Ltd has its own factory,so it has adequate stock. Also,Xi'an Sonwu has clean and tidy producing department with advanced equipment. With the lead of Xi'an Sonwu, researchers are constantly developing new products to meet customer's need.
2.Xi'an Sonwu Biotech Co.,Ltd has advanced test equipment and professional testers, which all show that Xi'an Sonwu aims to supply accurate and effective data and good service.
Certificates
Packing
Recent Logistics
Except guarantee the product’s, the other most important thing is customers could receive the goods smoothly. So, Xi’an Sonwu supplies all kinds of courier according to different need.
FAQ
1. How to buy products from Xi'an Sonwu?
You can contact Xi'an Sonwu via email, phone, and social media.
2.How to ensure the product quality before ordering?
Each batch of products needs to be tested to provide customers with COA and other third parties.
3. How to pack and store Baricitinib powder?
Packaging: export grade sealed drum, vacuum sealed aluminum foil packaging, can also be packed according to customer needs.
Storage: please store in a cool and dry place to avoid bright light and high temperature.
If you want to buy Baricitinib, feel free to contact Xi'an Sonwu.
E-mail: sales@sonwu.com
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