3,3′-Diindolylmethane

Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of 3,3′-diindolylmethane in China. We warmly welcome yuo to wholesale bulk 3,3′-diindolylmethane for sale here from our factory. Quality products and reasonable price are available.

DIM Supplement
3,3′-Diindolylmethane is an essential class of indole alkaloids, and its structure widely exists in natural products, functional materials, and synthetic drug molecules. Diindolylmethane derivatives are commonly used in medicine, agricultural chemicals, and materials and are mainly synthesized through the reaction of indole with aldehydes, ketones, alcohols, ethers, and amines. DIM is formed by condensing two indole 3-carbinol molecules, and it is the main component of various condensation products of indole 3-carbinol. DIM is a polycyclic aromatic hydrocarbon compound that can scavenge free radicals, quench singlet oxygen, and has a strong antioxidant effect. Studies have shown that indole 3-carbinol and DIM can be used as chemopreventive agents in various diseases to prevent, inhibit and reverse the process of significant illnesses.
The application of this chemical substance in the market is more and more extensive. If you are interested in pure DIM, please get in touch with Xi'an Sonwu.

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Where To Buy DIM
Xi'an Sonwu Biotech Co. ltd. is a distributor with more than ten years of experience. Xi'an Sonwu has always insisted on quality first. Serving every customer well and satisfying is Xi'an Sonwu's pursuit. Xi'an Sonwu also strictly controls every step, from selection and search. Based on these, customers have given good feedback on the product and service. So if you need DIM powder or capsules, please get in touch with Xi'an Sonwu.
Xi'an Sonwu ultimately ensures product quality and also offers samples. Here is the quantity.

Customers' Good Comment

OEM Service
Xi'an Sonwu can supply raw powder and also DIM capsules.
So customers could customize the capsules and the following item.
1.  Customized capsules shells (size, color, material)
2.  Customized bottles(size, color, material, style)
3.  Customized packaging(vacuum foil packaging, box, drum)
4.  Customized label(paint film, matte film, optical mask)

What Exactly Does Diindolylmethane (DIM) Do For The Body

1. Affect the metabolic activation of bad cells
DIM can change the metabolic activation process of bad cells by regulating the enzymes related to the metabolism of bad cells, including phase I enzymes CYP1 and CYP2B families and phase II enzymes, to achieve the regulation of glutathione sulfur transferase. A four-week administration to rats could significantly inhibit the formation of mammary sarcoma induced by 7,12-dimethylbenz pallium and cardiac sinus sarcoma caused by benzopyrene. In addition, DIM can inhibit the metabolism of aflatoxins mediated by them by inhibiting human CYP1A1 and CYP1A2.

2. Effects on impaired cell proliferation and cell cycle
Estrogen receptor-positive breast bad cells MCF7 and negative breast bad cells MDA-MB-231 are representative cell lines of terrible breast cells. DIM has been found to significantly affect two lines of bad breast cells in the range of 0-100 μmol/L. Inhibition of proliferation, and this inhibition of proliferation, is related to cell cycle arrest in the G phase and increased expression of p21. Also, in these two cell lines, DIM can inhibit the expression of cyclin E2, Survivin, and Bcl-2, enhance the presentation of p27 and p57, and cause cell cycle arrest and apoptosis.
A recent study on prostate diseases showed that DIM could inhibit the progression from G1 to the S phase by up-regulating p27 and down-regulating the expression of the androgen receptor. Another study found that whether in androgen-dependent LNCaP or androgen receptor-negative DU145 prostate disease, DIM can arrest the G1 phase and significantly inhibit the expression of cdk2 and cdk4, accompanied by the up-regulation of p27 expression. These results suggest that DIM may have a significant inhibitory effect on prostate disease and is not affected by androgens. Another study showed that the 1:1 combination of DIM and isothiocyanate could cause many cell cycle arrests in the G2/M phase.

3. Increase the sensitivity of sarcoma cells to chemotherapy drugs

3,3′-Diindolylmethane can induce the apoptosis of squamous cells, bile duct epithelium, colon, cervix, and other sarcoma cells. The study found that the inhibitory effect of DIM on cervical SiHa cells was time-dose dependent. In addition, studies have shown that it can also increase the induction effect of chemotherapy drugs on sarcoma cell apoptosis and the sensitivity of sarcoma to these drugs. The apoptosis rate was significantly increased, which may be achieved by down-regulating Bcl-xL, XIAP, cIAP, and Surivin.
DIM also enhances the apoptosis-inducing effect of the EGFR inhibitor erlotinib. In terrible prostate cells, the use of 0.5 mg/L of daunorubicin combined with 60 μmol/L of DIM increased the growth inhibition rate of the combined drugs on bad cell cells from 27.8% to 69.9%, the rate of induced apoptosis rose from 3.2% to 47.0%, equivalent to the effect of 10 times the dose (5 mg/L) of IDA, showing that DIM can significantly enhance the growth inhibitory effect of IDA on PC-3M cells. Its mechanism is related to apoptosis related to the induction effect.

4. Inhibition of bad cell angiogenesis

DIM has an inhibitory effect on sarcoma angiogenesis, and five μmol/L DIM can significantly inhibit the proliferation, invasion, migration, and angiogenesis of HUVECs. The in vivo model found that it can also effectively inhibit the growth of human mammary gland cell MCF-7 deficient cell-bearing nude mice and show the effect of anti-sarcoma angiogenesis.

5. Effects on cell signal transduction pathways

Effects on NFrB

After DIM acted on breast disease, MCF-7 cells for 24 hours significantly inhibited the DNA-binding activity of NF-kB and the nuclear translocation ability of p65. In addition, many studies have found that DIM-induced apoptosis may be achieved through the regulation of the NF-kB pathway. In the study of breast diseases, DIM has a synergistic effect on the inhibition of NF-kB induced by the chemotherapy drug docetaxel, indicating that this is also an essential mechanism for DIM to enhance the chemosensitivity of docetaxel. In prostate disease cells, DIM can down-regulate the expression of its target genes such as VEGF, IL-8, uPA, and MMP-9 by inhibiting the DNA binding activity of NF-kB and then affect the angiogenesis, migration, and metastasis of harmful cells.

Effect on Survivin
Survivin, a classic inhibitor of caspase-9, is one of the critical molecules regulating apoptosis. Survivin is related to multiple signaling pathways, affecting bad cells' proliferation and cell cycle. Survivin has become a potentially important target for preventing and treating harmful cells. DIM can reduce the expression of Survivin in breast disease cell MDA-MB-231, and interfering Survivin expression with si-RNA can further enhance the apoptosis and growth inhibition of breast disease cells induced by DIM. When Survivin is overexpressed, DIM Apoptosis and growth inhibition are significantly blocked.

Effects on uPA and its receptors
uPA is a critical member protein of the urokinase plasminogen activation system. Existing studies have shown that uPA is closely related to the development and metastasis of various diseases. In the process of DIM-induced apoptosis of prostate disease cell PC3, along with the down-regulation of uPA expression, the cell proliferation and metastasis activity can be further reduced after using specific si-RNA to interfere with uPA, showing that uPA participates in the regulation of the effect of DIM on prostate disease. In addition, in the result of DIM on breast disease cells MDA-MB-231 and MCF-7, uPA is involved in the regulation.

Factory
1. Xi'an Sonwu has production, manufacturing, and storage plants with sufficient inventory. Xi'an Sonwu has an orderly and clean production department. At Xi'an Sonwu, researchers can continuously develop high-quality new products.
2. Xi'an Sonwu has strict staffing requirements from production and testing to sales. To ensure every product escort, provide uncompromising data support and after-sales service.

Certificate

Packing

Logistics

Xi'an Sonwu, besides guaranteeing product quality, the other thing is to help customers can receive the goods smoothly. So, Xi'an Sonwu can supply all kinds of couriers according to different needs.

FAQ
The primary purpose of DIM is to balance estrogen metabolism. Depending on the dose used, it can effectively affect estrogen levels in the body. DIM also prevents testosterone from producing estrogen through an aromatase inhibitor. Too high a DIM amount has the opposite effect, increasing estrogen synthesis. It can also affect the metabolism of estrogen, making it less effective.
If you want to know a DIM manufacturer, you can contact Xi'an Sonwu. Click the email then you get high-quality 3,3′-Diindolylmethane.
Email: sales@sonwu.com

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