Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of marbofloxacin powder in China. We warmly welcome yuo to wholesale bulk marbofloxacin powder for sale here from our factory. Quality products and reasonable price are available.
Marbofloxacin
Marbofloxacin powder, MBF for short, is a new fluoroquinolone antibiotic. It is often suggested to treat bacterial infections in animals. Especially for veterinary-grade use for acute upper respiratory tract infections in cats and dogs, skin and soft tissue infections, deep and superficial skin infections, and dog urinary tract infections. MBF prevents the growth and spread of bacteria by impeding the action of specific enzymes required for DNA from bacteria synthesis. MBF has been clinically used to treat deep and Superficial skin infections, urinary tract infections, infections of the soft and skin tissues, as well as severe upper respiratory tract infections that affect cats. Pharmacokinetic studies on MBF in cattle, sheep, chickens, and pigs also show that the drug has great potential in treating the digestive tract, respiratory tract, genitourinary tract, and livestock and poultry skin infections. With the wide application of 99 veterinary marbofloxacin, there are more and more suppliers in the market; if you need wholesale MBF, Xi'an Sonwu can provide it.
Certificate Of Analysis
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ANALYSIS |
SPECIFICATION |
RESULTS |
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Appearance |
Light yellow crystalline powder |
Complies |
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Solubility Water Methylene chloride Ethanol(96%) |
Slight suluble Sparingly soluble Very slightly soluble |
Complies Complies Complies |
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Assay (Dried substance) |
99.0%~101.% |
99.53% |
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Identification I.R. Spectrum |
Concordant with the spectrum of reference substance |
Complies |
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Absorbance |
≤0.20 |
0.15 |
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Related substances |
Impurity A |
≤0.1% |
Not detected |
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Impurity B |
≤0.1% |
Not detected |
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|
Impurity C |
≤0.2% |
0.01 |
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Impurity D |
≤0.2% |
Not detected |
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Impurity E |
≤0.2% |
Not detected |
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Unspecified Impurity |
≤0.2% |
0.14 |
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Total Impurity |
≤0.5% |
0.33 |
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Heavy Metal |
<20ppm |
<20ppm |
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Loss on drying |
<0.5% w/w |
0.09 |
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Sulphated ash |
<0.10% w/w |
0.01 |
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Residual solvents |
Ethanol |
<5000ppm |
284ppm |
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Dichloromethane |
<600ppm |
Not detected |
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Where To Buy Marbofloxacin
Xi'an Sonwu Biotech Co. Ltd. has more than ten years of manufacturing experience. Xi'an Sonwu has established solid and reliable partnerships with countries in America, Asia, Europe, and Oceania. Xi'an Sonwu puts product quality first and strives to provide every customer with high-quality services to meet their needs fully.
Xi'an Sonwu prioritizes high-quality products, and its commitment to excellence is evident in every aspect, including material selection, manufacturing techniques, sample testing, and the professionalism of its personnel. By meticulously managing every detail, Xi'an Sonwu can minimize costs without compromising quality, ensuring customers receive products of exceptional value.
Xi'an Sonwu is proud of the positive feedback it has received from customers, who have consistently recognized the quality of the products. To further prove product confidence, Xi'an Sonwu will provide samples for you to test.
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MBF Form |
Sample Amount |
MOQ |
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Powder |
50g |
100g |
Customers's Good Comment
How Does Marbofloxacin Work
MBF's mode of action involves targeting specific bacterial enzymes called DNA gyrase and topoisomerase IV. Bacterial DNA replication, transcription, and repair depend on these enzymes.
MBF is an antibiotic in the fluoroquinolone family. Although it shares a similar structural makeup to other fluoroquinolones, it has distinct qualities that enable it to have a broader range of effectiveness against different bacteria. The primary target of marbofloxacin is DNA gyrase. DNA gyrase is responsible for introducing negative supercoils into the bacterial DNA molecule, which is crucial for DNA replication and transcription. By inhibiting DNA gyrase, MBF disrupts the normal functioning of the enzyme and prevents the proper coiling and unwinding of bacterial DNA.
In addition to targeting DNA gyrase, it also affects topoisomerase IV. Topoisomerase IV is involved in separating interlinked daughter chromosomes during bacterial cell division. By inhibiting this enzyme, MBF disrupts the separation process, forming abnormal DNA structures and inhibiting bacterial cell division.
By targeting these two enzymes, marbofloxacin interferes with vital bacterial DNA processes, inhibits bacterial growth, and eventually leads to the death of susceptible bacteria.
What Is The Function Of Marbofloxacin
Marbofloxacin powder has the characteristics of a broad antibacterial spectrum and vigorous antibacterial activity. Its activity on aerobic bacteria is similar to or slightly more potent than ofloxacin, and it shows higher activity than ofloxacin on most anaerobic bacteria. The in vitro activity of MBF was tested against 816 strains of clinically isolated bacteria that caused illness in dogs and cats. The study showed it was more effective against most Gram-positive organisms and more sensitive to Gram-negative microbes. After MBF, the MIC90 for Pasteurella multocida was 0.08-0.28 g/ml, and for most Enterobacteriaceae (including E. coli, Klebsiella, and Proteus), MIC90 was 0.08-0.28 g/ml. The result was higher at 3.8g/ml. In addition, MBF also has increased activity on some pathogenic bacteria of cattle, such as Pasteurella hemolyticus, Pasteurella multocida, and Haemophilus sleeping.
MBF could still successfully inhibit Staphylococcus intermedia and Pseudomonas aeruginosa 24 hours after administration in dogs' simulated in vivo antibacterial activity test. At the same time, enrofloxacin could not stop the regrowth of the bacteria above.
As can be seen, while enrofloxacin has somewhat higher in vitro activity than MBF against Staphylococcus intermedius and Pseudomonas aeruginosa, MBF has better, longer-lasting antibacterial action in simulated in vivo circumstances.
By controlling the inflammatory response that macrophages are a component of, MBF can also boost macrophage activity and support the body's non-specific immunological function.
MBF also exhibits post-antimicrobial effects (PAE). The PAE values of MBF to several main pathogenic bacteria in dogs and cats are 1.6-2.4h and 1.0-1.7h, respectively. Because MBF has a good PAE, its antibacterial activity in various body fluids and tissues can last 24 hours or longer.
Marbofloxacin Veterinary Use
1. Small animals
MBF has been used to treat various skin, urinary tract, digestive tract, respiratory tract infections, and postoperative infections in dogs and cats. It was more effective at 2 mg/kg than enrofloxacin in dogs with Pseudomonas aeruginosa and moderate staphylococcus infections. Pyoderma in dogs caused by Staphylococcus intermedia and Escherichia coli and cat pyoderma carried on by Staphylococcus aureus may be treated effectively.
Experimental results show that MBF + amoxicillin + clavulanic acid is mixed, the dose is 2mg/kg, once a day, and utilized consistently for five days to track the outcomes of the acute upper respiratory infection in cats cure rate. It is found that this combination can make the cure. The speed reaches 77.8%~87.8%. The cure rate of canine urinary tract infection can get 85.0%~96.2% with MBF + amoxicillin + clavulanic acid mixture.
2. Cattle and sheep
MBF has good activity on a variety of respiratory pathogens of cattle, such as Pasteurella multocida, Pasteurella hemolytic, Haemophilus sleeping, and Mycoplasma bovis, which makes it a good prospect in the treatment of livestock respiratory diseases. In addition, after administration, MBF can quickly and widely penetrate milk, reach a higher concentration, and maintain it for a long time. It can also be used to treat mastitis in cattle and sheep.
3. Pigs and poultry
Parenteral administration of MBF can be used to treat mastitis, metritis, and agalactia in sows, but there is no report of using MBF to treat poultry diseases. Clinically, it can be combined with enrofloxacin and norfloxacin Flufloxacin, etc., are used as controls for treating livestock and poultry diseases to broaden the scope of application of MBF further.
Factory
1. Xi'an Sonwu Biotech Co., Ltd has its factory to produce, manufacture and store the products, so have adequate stock. Xi'an Sonwu has a well-ordered, clean, and tidy production department. Under Xi'an Sonwu, researchers can continuously develop high-quality new products.
2. Xi'an Sonwu has strict requirements on personnel allocation from production and testing to sales. To ensure that each product is escorted, rigorous data support and after-sales service are provided.
Certificate
Package
Logistics
Besides guaranteeing the product, the other most important thing is customers can receive the goods smoothly. So, Xi'an Sonwu supplies all kinds of couriers according to different needs.
FAQ
Should MBF be given with food?
MBF can be given with food or by itself, depending on specific instructions provided by your veterinarian. However, taking it on an empty stomach or at least several hours before or after meals is recommended.
Food, especially meals high in fat, may prevent it from adequately absorbing from the digestive tract, reducing its effectiveness. Administering MBF on an empty stomach helps ensure optimal absorption and distribution of the medication.
In addition, oral ingestion of metal cations, including calcium, iron, magnesium, aluminum, and others, may lessen the star's bioavailability.
When theophylline is given in conjunction with it, the dosage needs to be decreased.
If you want to know a marbofloxacin supplier, you can contact Xi'an Sonwu. Click the email then you get 99 veterinary marbofloxacin powder.
Email: sales@sonwu.com
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