Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of ceftiofur free acid powder in China. We warmly welcome yuo to wholesale bulk ceftiofur free acid powder for sale here from our factory. Quality products and reasonable price are available.
What Is Ceftiofur Crystalline Free Acid
Ceftiofur free acid powder (CCFA) is an antibiotic drug in the crystalline form of ceftiofur, mainly used in veterinary medicine. It belongs to the cephalosporin class of drugs, especially the third-generation cephalosporins. Ceftiofur crystalline free acid has broad-spectrum activity against Gram-negative and Gram-positive bacteria, including Escherichia coli, Salmonella, and Klebsiella. CCFA works by inhibiting the growth of bacteria and interfering with their cell wall synthesis. This disruption eventually kills the bacteria and helps resolve the infection. CCFA refers specifically to the crystalline form of ceftiofur processed in the free acid form. It has enhanced stability and solubility compared to other forms of ceftiofur, making it suitable for use in veterinary medicine. Its unique properties allow for a more sustained release of the active drug, prolonging the therapeutic effect.
Ceftiofur crystalline-free acid is commonly used to treat bacterial infections in animals, especially cattle, pigs, and horses. Various pathogens, such as Escherichia coli, Pasteurella multocida, Haemophilus somnus, and Mannheimia haemolytica, can cause these infections. Of note, ceftiofur crystalline-free acid is for veterinary use only and should not be used in humans unless specifically prescribed by a healthcare professional.
If bacteria infect your animal, please remember to treat it urgently. Xi'an Sonwu currently has bulk ceftiofur crystalline-free acid in stock. It can be sent to you within 24 hours if needed.
Certificate Of Analysis
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Test |
Specification |
Result |
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|
Character |
Off-white to yellow powder |
Off-white powder |
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|
Identification |
1. In the chromatogram of the assay, the retention time of the principal peak in the chromatogram obtained with the test solution corresponds to that of the principal peak in the chromatogram obtained with reference solution |
Conform |
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|
Water |
Not more than 3.0% |
0.35% |
|
|
Acidity(pH) |
5.5~7.5 |
6.2 |
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|
Color of solution |
No more intensity colored than reference solution Yedllow 9 or Orange-yellow 9 |
Conform |
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Clarity of solution |
No more pronounced than that of reference suspension I |
Clear |
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|
Assay (Ceftiofur sodium) |
No less than 98.0%(anhydrous and acetoe free) |
98.8% |
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|
Related substances |
Biggest individual impurity |
No more than 0.5% |
0.1% |
|
Total |
No more than 3.0% |
0.98% |
|
|
Residual solvents |
Acetoe: no more than 2.0% |
1.0% |
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|
Particulate matter |
≥10μm:no more than 5000 particles/g |
597 particles/g |
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|
≥25μm:no more than 500 particles/g |
27 particles/g |
||
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Bacterial endotoxin |
No more than 0.2EU/mg (Ceftiofur) |
Conform |
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Sterility |
No growth of micro-organisms should occur after 14 days of incubation |
Conform |
|
Where To Buy Ceftiofur Crystalline Free Acid
Xi'an Sonwu Biotech Co. Ltd. is a manufacturer and distributor with more than ten years of experience. It has extensive and stable cooperation with countries worldwide in the Americas, Asia, Europe, and Oceania. Xi'an Sonwu has always insisted on product quality first; serving every customer well and satisfying every customer is Xi'an Sonwu's pursuit. Xi'an Sonwu strictly controls every step, from the selection of raw materials, and pursues high-quality products from all aspects, such as material selection, manufacturing, sample testing, and personnel professionalism. In addition, Xi'an Sonwu strives to handle every detail to minimize costs and allow customers to get products with high-cost performance. Based on these, customers have given good feedback on the product. So if you need any veterinary raw materials, don't hesitate to contact Xi'an Sonwu.
Xi'an Sonwu ultimately ensures the product's quality and offers a sample for your test. Here is the quantity.
|
CCFA Form |
Sample Amount |
MOQ |
|
Powder |
100g |
1kg |
Customers's Good Comment
What Is The Mode Of Action Of Ceftiofur
Ceftiofur free acid powder is an antibiotic in the cephalosporin class of drugs. Its action includes inhibiting the growth of bacteria and interfering with their cell wall synthesis. Ceftiofur targets the bacterial cell wall, a vital structure that gives the bacteria strength and shape.
To understand how ceftiofur works, it is essential first to have some background knowledge of the bacterial cell structure. A cell membrane composed of peptidoglycan layers surrounds the bacterial cell. The peptidoglycan layer is a network of sugar chains called glycan chains cross-linked by short peptide chains. Ceftiofur targets bacterial cell walls primarily by binding to specific proteins called penicillin-binding proteins (PBPs). PBPs are enzymes involved in the synthesis and remodeling of the peptidoglycan layer. They catalyze the cross-linking of glycan chains through the formation of peptide bonds, contributing to the structural integrity and stability of the cell wall.
When ceftiofur binds to PBP, it interferes with its enzymatic activity. This disruption prevents the correct cross-linking of peptidoglycan chains, forming weakened and defective cell walls. The fragile cell wall cannot withstand normal osmotic pressure and structural requirements, leading to lysis or rupture of the bacterial cell. In addition, the interaction of ceftiofur with PBP also disrupts the enzymatic function of transpeptidase, the enzyme responsible for forming peptide bonds during cross-linking. By inhibiting transpeptidase activity, ceftiofur impairs the formation of stable peptide bonds in the peptidoglycan layer, further leading to cell wall defects. Ceftiofur breaks down the bacterial cell wall, eventually leading to the death of the bacteria. Weakened cell walls and increased permeability make bacteria more susceptible to osmotic pressure, causing them to rupture or lyse. This destruction of the bacterial cells prevents them from growing and multiplying, effectively controlling the infection.
What Bacteria Does Ceftiofur Treat
Here are some examples of the main bacterial species that ceftiofur can target:
1. Enterobacteriaceae
Ceftiofur is effective against various members of the Enterobacteriaceae family, such as Escherichia coli, Salmonella spp., Klebsiella spp., and Enterobacter spp. These bacteria are commonly associated with urinary tract infections, respiratory tract infections, gastrointestinal infections, and septicemia.
2. Staphylococcus spp.
Ceftiofur has activity against certain strains of Staphylococcus aureus, including methicillin-susceptible Staphylococcus aureus (MSSA). These bacteria can cause soft tissue, skin, and more serious systemic infections.
3. Streptococcus spp.
Ceftiofur can be effective against some species of Streptococcus, such as Streptococcus pyogenes and Streptococcus agalactia. These bacteria cause various infections, including pharyngitis, skin and soft tissue infections, and respiratory tract infections.
4. Pasteurella multocida
Ceftiofur is commonly used to treat infections caused by Pasteurella multocida, particularly in animals. This bacterium is a common pathogen in respiratory tract infections in cattle, swine, and other domesticated animals. In addition to these bacteria, ceftiofur targets pathogens like Haemophilus spp ., Moraxella spp., Actinobacillus spp., and various other bacteria associated with respiratory and systemic infections.
Ceftiofur has a broad-spectrum bactericidal effect and is effective against Gram-positive and Gram-negative strains, including lactamase-producing songs. Sensitive bacteria include Pasteurella, Actinobacillus, Salmonella, Streptococcus, and Staphylococcus. The antibacterial activity is more substantial than ampicillin, and the action against Streptococcus is also more significant than quinolone antibacterial drugs. Pathogenic bacteria have been isolated from bovine respiratory disease materials. After testing, their M1C90 are: Pasteurella hemitrope ≤0.06 (0.03~0.13), Pasteurella multocida ≤0.06 (0.03~0.25), Haemophilus somniferous (≤0.06 (0.03~0.13), is highly sensitive. Bordetella bronchitis is resistant to this product. The MIC90 against swine pathogens are Actinobacillus pleuropneumoniae ≤0.03, Pasteur multocida Bacillus ≤0.03, Pasteurella multocida ≤0.03, and Salmonella cholera ≤01.0, Salmonella typhimurium 2.0, Escherichia coli 1.0.
What Are The Side Effects Of Ceftiofur
1. Allergic reactions include erythema, urticaria, itching, drug fever, occasionally angioedema, asthma, and hypotension.
2. Gastrointestinal reactions such as nausea, vomiting, and diarrhea.
3. Serum alanine aminotransferase can be slightly elevated.
4. Rarely have nervous system reactions such as headache and dizziness.
Factory
1. Xi'an Sonwu Biotech Co., Ltd has its factory to produce, manufacture and store the products, so have adequate stock. Xi'an Sonwu has a well-ordered, clean, and tidy production department. Under Xi'an Sonwu, researchers can continuously develop high-quality new products.
2. Xi'an Sonwu has strict requirements on personnel allocation from production and testing to sales. To ensure that each product is escorted, rigorous data support and after-sales service are provided.
Certificate
Packaging
Logistics
Besides guaranteeing the product, the other most important thing is customers can receive the goods smoothly. So, Xi'an Sonwu supplies all kinds of couriers according to different needs.
FAQ
1. The application of this product to horses under stress conditions may be accompanied by acute diarrhea, which can be fatal. Once this happens, stop the drug immediately and take corresponding treatment measures.
2. Use cefotaxime sodium according to the prescribed dose, course of treatment, and route of administration. There is no withdrawal period before slaughter and no milk waste period.
3. The kidneys mainly excrete it. For animals with renal insufficiency, attention should be paid to adjusting the dose.
If you want to know ceftiofur price, you can contact Xi'an Sonwu. Click the email then you get high-quality ceftiofur free acid powder.
Email: sales@sonwu.com
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