Geniposide Powder

Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of geniposide powder in China. We warmly welcome yuo to wholesale bulk geniposide powder for sale here from our factory. Quality products and reasonable price are available.

Geniposide Supplement
Geniposide powder, also known as gardenia and geniposidic, is an iridoid glycoside, a product extracted from the dried and mature fruits of the Rubiaceae plant gardenia. Gardenia contains more than 40 physiologically active substances, among which the active ingredient of gardenia, a traditional Chinese medicine recognized at home and abroad, is iridoids. The iridoids contained in gardenia include gardeniposide, geniposidic, hydroxygeniposide, etc. Among them, the most active ingredients are gardeniposide and geniposidic. Gardenia glycoside is an intermediate in the production of gardenia blue, gardenia red, and gardenia violet and is also an effective monomer for crude drugs.
Modern research shows that it significantly affects diseases of the digestive system, cardiovascular system, and central nervous system. In addition, it also has specific anti-inflammatory and soft tissue damage effects. In addition to its medicinal uses, it is also widely used in other fields. Fermentation under different conditions can produce natural food pigments, geniposidic blue, and Gardenia red, which are also used to treat cardiovascular, cerebrovascular, hepatobiliary, and other diseases, such as diabetes. Due to its potential therapeutic efficacy, it has been the subject of attention in traditional medicine and modern research. It has shown promise in various preclinical studies for treating conditions such as inflammation, oxidative stress, cognitive impairment, and diabetes. If you are also interested in individual implants, please get in touch with Xi'an Songwu. Xi'an Songwu can provide you with pure geniposidic.

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Where To Buy Extract Powder Geniposide
Xi'an Sonwu Biotech Co. Ltd. has more than ten years of industry experience specializing in producing and selling raw materials. Xi'an Sonwu has established solid and reliable partnerships with countries in America, Asia, Europe, and Oceania. Xi'an Sonwu puts product quality first and strives to provide every customer with high-quality services to meet their needs fully.
Xi'an Sonwu prioritizes high-quality products, and its commitment to excellence is evident in every aspect, including material selection, manufacturing techniques, sample testing, and the professionalism of its personnel. By meticulously managing every detail, Xi'an Sonwu can minimize costs without compromising quality, ensuring customers receive products of exceptional value.
Xi'an Sonwu is proud of the positive feedback it has received from customers, who have consistently recognized the quality of the products. To further prove product confidence, Xi'an Sonwu is pleased to provide extract powder geniposide samples for you to test.

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What Is The Function Of Geniposide
1. Hypoglycemic and lipid-lowering effects
Geniposide powder can significantly reduce blood sugar and improve glucose tolerance in diabetic model rats. Glucose consumption tests showed that geniposidic can substantially promote glucose absorption by preadipocytes, and its hypoglycemic effect in vivo and in vitro may be related to the activation of PPARy.

2. Hepatoprotective and choleretic effects
Gardenia is the main ingredient in gardenia with hepatoprotective and choleretic effects. Studies have shown that administering geniposidic through the duodenum of rats can significantly increase the bile flow and reduce the cholesterol content in the bile of rats. Gardeniposide can prevent liver cell damage and reduce the density of P450 3A immune-related protein in liver microsomes. The hepatoprotective mechanism of geniposidic against non-alcoholic fatty liver disease may be related to its anti-oxidation, regulation of adipocytokine release, and PPARα expression.

3. Neurotrophic and neuroprotective effects
Geniposide can reduce the expression of inflammatory factors such as TNF-α, IL-1β, and ICAM-1 in the brain of rats with cerebral ischemia and minimize ischemia damage to cranial nerves. Experimental studies have found that gardenia crude extract with gardenia glycoside as the main component can improve dementia-like model mice's learning and memory functions. Experiments have confirmed that it can inhibit the expression of HIF-1α and HIF-1-dependent apoptosis-related gene RTP801 mRNA caused by focal cerebral ischemic injury, thereby reducing neuronal apoptosis.

4. Antithrombotic and fibrinolytic effects
Studies on the bypass circulation thrombosis model and the standard carotid artery thrombosis model have shown that it and its aglycone can significantly prolong coagulation and bleeding time and reduce the thrombus weight in the two models. Gardeniposide and its metabolite can substantially delay the occlusion time of femoral artery thrombosis in rats and inhibit the activity of phosphatidase.

5. Treatments for Osteoarthritis
Gardeniposide can promote the proliferation of ligament fibroblasts, tissue repair, and healing of ligament injuries. After using it to intervene in the rabbit knee osteoarthritis model, it was found that the histological score of the osteoarthritis animal model was improved. Gardenia is clinically effective in healing sprains and contusions, and studies have shown that it can stimulate fibroblast proliferation and collagen formation.

6. Anti-inflammatory effects
Studies have shown that the therapeutic effect of gardenia total glycosides on rheumatoid arthritis (RA) is related to its inhibition of inflammatory cytokine activity and reduction of provocative mediator content in inflammatory lesions. Gardenia total glycosides inhibit NO and nitric oxide synthase (NOS). ) level is an essential mechanism of its anti-RA action. Studies have found that gardeniposide can prevent human umbilical cord vein endothelial cells from producing interleukin 6 IL-6 and IL-8 induced by lipopolysaccharide. The medium and high dose (15 mg/kg, 30 mg/kg) groups of gardenia total cycloid could significantly reduce the levels of cell necrosis factor (TNF-α) and IL-1β in brain tissue around the hematoma, inhibit The expression of ICAM-1 exerts an inhibitory effect on the initiation of upstream signals of the inflammatory response, and has a protective effect on secondary brain damage caused by the inflammatory response after cerebral hemorrhage.

7. Antioxidant effect
Geniposidic activates the glucagon-like peptide-1 receptor (GLP-1R), promotes the production of intracellular cAMP, activates the downstream PI3K/Akt-Nrf2 signaling pathway, and increases the activity of heme oxygenase (HO-1) Expression, resists oxidative damage to nerve cells caused by H2O2 and ONOO-donor (SIN-1). It was found that gardeniposide can upregulate the movement of the intracellular oxidative defense system, scavenge free radicals, and promote the generation and release of endogenous NO, thereby protecting cells from oxidative stress damage.

8. The role of the original body
Geniposidic has a direct neutralizing effect on lipopolysaccharide (LPS) in vitro and shows an excellent dose-effect relationship; at the same time, it can dose-dependently inhibit the activation of TLR4 and TNF in RAW264·7 cells caused by LPS stimulation - The expression of an RNA is downregulated, and the production of cytokine TNF-α is reduced; it can reduce the LPS level in the blood of LPSemia model animals in vivo; it has a significant protective effect on mice challenged with lethal doses of heat-inactivated Escherichia coli. , it was clarified that gardenia glycoside is the active ingredient of gardenia in antagonizing bacterial sepsis.

Factory
1. Xi'an Sonwu Biotech Co., Ltd has a factory to produce, manufacture, and store the products, so it has adequate stock. Xi'an Sonwu has a well-ordered, clean, and tidy production department. Under Xi'an Sonwu, researchers can continuously develop high-quality new products.
2. Xi'an Sonwu has strict requirements on personnel allocation from production and testing to sales. To ensure that each product is escorted, rigorous data support and after-sales service are provided.

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Besides guaranteeing the product, the other most important thing is customers can receive the goods smoothly. So, Xi'an Sonwu supplies all kinds of couriers according to different needs.

FAQ
Geniposidic is a natural compound found in various plants, including Gardenia jasminoides. Some reported side effects of geniposidic include:

Gastrointestinal Issues: Some individuals may experience stomach upset, nausea, or diarrhea after consuming it.

Liver and Kidney Effects: There is some concern that it may affect liver and kidney function, particularly at high doses.

Allergic Reactions: As with any natural compound, allergic reactions are possible in some individuals.

Other Potential Side Effects: Additional side effects may be identified through ongoing research and individual reactions.

If you want to know the extract powder geniposide manufacturer, you can contact Xi'an Sonwu. Click the email, and then you get high-quality geniposide powder.
Email: sales@sonwu.com

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