Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of magnesium threonate powder in China. We warmly welcome yuo to wholesale bulk magnesium threonate powder for sale here from our factory. Quality products and reasonable price are available.
What is magnesium l-threonate?
Magnesium threonate powder derives from magnesium l-threonate, also called l-threonic acid magnesium or magnesium threonate, which is a synthesized form of magnesium that forms when threonic acid combines with magnesium. Threonic acid is a byproduct that occurs when vitamin C breaks down metabolically. It was developed by a team of neuroscientists at Massachusetts Institute of Technology and Tsinghua University in Beijing that bound magnesium to l-threonate, a vitamin C metabolite. Magnesium is probably one of the most underrated supplements available today. Its health benefits are not as well-known as other popular supplements, like vitamin C or vitamin E, but they are just as important. It can help in the development of the brain and nervous system. This form of magnesium may have potential brain-related benefits and could be useful for managing certain brain disorders like age-related memory loss and depression. It exhibits anti-stress, anti-anxiety, anti-depressive, and neuroprotective properties. Xi'an Sonwu, as magnesium l-threonate supplier, can provide high purity powder with high quality and competitive price. If you're interested in, please feel free to contact Xi'an Sonwu.
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Specification
ANALYSIS | SPECIFICATION | RUSULT |
Appearance | White Crystalline Powder | Conforms |
Assay | ≥99% | 99.4% |
Identification | IR spectrum of sample corresponds to that of reference standard. | Conforms |
Appearance of Solution | Clear | Conforms |
Grade Standard | Food Grade; Medicine Grade | Conforms |
PH | 5.8-7.0 | Conforms |
Heavy Metals | ≤10ppm | Conforms |
Type | Vitamins, Amino Acids & Coenzymes | Conforms |
Usage | Animal Pharmaceuticals | Conforms |
Water Solubility | Soluble | Conforms |
Loss on drying | ≤1.0% | Conforms |
Conclusion | Conforming to Enterprise Standard | |
What does magnesium l-threonate do for the brain?
As you might have guessed, the key benefits of magnesium l-threonate involve the brain. Numerous research studies indicate that the beneficial components of it primarily target the brain. It has been shown to help with age-related memory loss, emotional disorders, neuro-inflammation, and enhance cognitive function.
For these reasons, the powder is beneficial for people suffering from:
-Parkinson's disease
-Alzheimer's disease
-Poor memory
-Depression
-Anxiety
-Post-traumatic stress disorder
-Difficulty in sleeping
-Difficulty in focusing
Improving Parkinson's Disease
Magnesium is essential for cell function and a lack of magnesium can result in neurological disorders. A research study conducted in China used magnesium l-threonate to elevate the levels of magnesium within cerebrospinal fluid and reduce motor deficits and dopamine neuron loss in a mouse model with Parkinson's disease. The results showed that the supplement significantly increased the magnesium levels in the cerebrospinal fluid and it also remarkably reduced the MPTP-induced motor deficits and DA neuronal degeneration in mice. MPTP is a chemical compound that acts as a prodrug for the neurotoxin MPP. As a result, it causes permanent symptoms of Parkinson's disease by damaging the dopaminergic neurons found in the substantia nigra of the brain. Reducing the MPTP-induced motor deficits delays, and possibly prevents, the onset of Parkinson's disease symptoms.
Enhancing Memory And Learning Capabilities
Memory and knowledge gained through learning are fundamental brain functions frequently influenced by dietary and environmental factors.
In a 2010 study, researchers wanted to improve learning and memory in rats by increasing the brain's magnesium levels through the use of magnesium l-threonate. The researchers first discovered that increasing brain MG2+ levels in both young and aged rats could enhance various learning forms and memory retention. Administering chronic treatment showed an increase in the activation of downstream signaling molecules in the hippocampus. It corresponded to a significant increase in short-term synaptic facilitation and long-term potentiation, which are both important in learning and memory. In conclusion, the supplement effectively raises magnesium levels in the brain and improves learning and memory in both young and old rats. Given magnesium's critical role in the human brain, its application may have a similar effect on human subjects.
Another experimental trial used the powder to prevent and restore short–term memory loss associated with neuropathic pain. According to recent clinical studies, about two-thirds of patients with chronic pain suffer from short-term memory loss and currently, no drugs effectively treat these neurological disorders. It showed that chronic oral administration of magnesium l-threonate could prevent and restore short-term memory deficits and LTP at CA3-CA1 synapses in the hippocampus caused by SNI. The preventative and therapeutic oral application of the powder blocks the regulation of tumor necrosis factor alpha in the hippocampus, which is critical for memory deficits.
Helping Treating Alzheimer's Disease
Alzheimer's disease is associated with magnesium ion deficits and interleukin-1β elevations in the brains of AD patients. To address this issue, cellular and molecular immunology researchers conducted a study on magnesium ion influx to reduce neuroinflammation and suppress the expression of interleukin-1β which terminates the possibility of Alzheimer's disease.
Mice and rats are commonly used in Alzheimer's research because they have good memories and develop brain diseases similar to those experienced by humans. The researchers used two model systems: human cells and mouse brain glial cells. They discovered that the supplement suppresses IL-1β in glial cells outlined within the signaling pathways. Incubating magnesium l-threonate stimulates the activity of extracellular signal-related protein kinase and peroxisome proliferator-activated receptor-gamma (PPARγ) signaling pathways by phosphorylation. The powder shows potential for treating dementia and Alzheimers disease.
Improving Anxiety And PTSD
Some research suggests that magnesium also helps with anxiety and post-traumatic disorder. A study in 2011 examined the effects of elevating brain magnesium on fear conditioning, fear extinction, and neuronal plasticity in specific areas of the brain. Anxiety and PTSD are common in adults, and there are cases where cognitive therapies cannot treat the condition.
The researchers used magnesium l-threonate (MgT) to treat anxiety disorders in rats by administering MgT orally and investigating the basis of MgT treatment on fear memory and extinction. The results show that increasing the amount of magnesium in the brain improves synaptic plasticity in the hippocampus and the learning and memory of rats.
This just shows that increasing brain magnesium levels can improve synaptic plasticity in a region-specific manner, allowing it to enhance the efficacy of extinction without enhancing or impairing fear memory formation. This means that specific receptors suppress any fear-related memory to the extent that it does not interfere with the good memories.
How does magnesium l-threonate get into the brain?
Magnesium comes in many different forms, but there's always been a quandary surrounding the use of magnesium supplements for cognitive and mental health issues — they do not readily enter the brain. Before any substance can reach the brain via the bloodstream, it must pass through a "filter" membrane called the blood-brain barrier (BBB). It's essentially the bouncer on the door, keeping out potential troublemakers and carefully controlling numbers inside. Magnesium can come in but it has to be escorted, limiting the amount that gets through. Unlike other forms of magnesium supplement (e.g. citrate, oxide), l-threonate is highly effective at escorting magnesium across the BBB. Most magnesium supplements are chelated and magnesium l-threonate is no exception. Chelated simply means that the magnesium molecules are bonded to another molecule. Chelation can improve a magnesium supplement's stability, absorption, and bioavailability. Magnesium l-threonate is the latest magnesium chelate.
Here are the three known ways in which magnesium l-threonate works:
1. Magnesium l-threonate readily crosses the brain's protective filter, the blood-brain barrier, to get into the brain where it is needed.
2. Magnesium l-threonate has been shown to increase brain plasticity. Neuroplasticity (brain plasticity) is the brain's ability to change and grow, and is fundamental for memory and learning to take place.
3. There's evidence that magnesium l-threonate can increase brain-derived neurotrophic factor (BDNF), a protein that stimulates the formation of new brain cells.
How much magnesium l-threonate should I take?
Magnesium threonate powder promotes brain development and reduces the likelihood of developing any brain-related disorders. Unlike other types of magnesium, magnesium l-threonate is more bioavailable and can readily cross the blood-brain barrier. It is available in powder and capsule forms, allowing you to take it with you wherever you go.
The dosage hinges on a few factors, including sex, age, and the intended use. For instance, a typical dose for 19 to 30-year olds is about 400mg while females will use about 300mg. Anyone above 31 years can raise the quantity by 20mg, for both sexes. When taking the supplement for boosting cognition, the dose may shoot up to 1200mg per day. Contrary, the amount falls to 400mg when using magnesium l-threonate sleep supplement for its hypnotic properties. When taking this compound as a dietary supplement, you can use between 1000mg and 2000mg per day.
In short, it is recommended that you consult a doctor before taking it.
Side Effects
Magnesium l-threonate can be taken on a full stomach in the morning and evening to reduce any discomfort or side effects. Yes, there may be side effects, but they will be milder than you might think. It is simply the body's natural reaction to a new substance.
However, taking too much magnesium can cause loose stools or watery bowel movements. This is most commonly seen in people who exceed dosages of 1,000 mg. Generally, magnesium l-threonate is one of the most gentle forms of magnesium and is not likely to result in this side effect as much as other forms.
In some cases, people tend to feel drowsy after taking it. Others may experience mild headaches, while some can feel an increased sensation of blood flow in the head. These side effects are minor and may only last a few minutes or hours, but if you are uncomfortable then don't ignore them.
You should consult your doctor or medical care provider before taking magnesium l-threonate, especially if you are taking antibiotics, blood thinners, muscle relaxants, or have a history of hypertension or osteoporosis. It is also strictly forbidden for people who have kidney disease.
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Why choose us
1. Xi'an Sonwu has been engaged in import-export for over 10 years with rich experience in development, research and production of API, plant extract, food additives, and other raw ingredients of health care products.
2. Xi'an Sonwu has a professional team with clear division of labor.
3. Products are tested by third parties.
4. OEM service is available.
If you need and want to buy magnesium threonate powder, welcome to contact Xi'an Sonwu.
Email ID: sales@sonwu.com
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