Dihydroartemisinin Powder

Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of dihydroartemisinin powder in China. We warmly welcome yuo to wholesale bulk dihydroartemisinin powder for sale here from our factory. Quality products and reasonable price are available.

What Is Dihydroartemisinin

Dihydroartemisinin powder is a potent antimalarial compound and the active metabolite of artemisinin, a natural product derived from the plant Artemisia annua. It belongs to the artemisinin class of drugs, which have revolutionized the treatment of malaria, particularly in areas where drug resistance is a significant concern. DHA is widely used as part of artemisinin-based combination therapies (ACTs) to effectively treat uncomplicated malaria cases caused by Plasmodium falciparum, the most lethal malaria parasite species.

Artemisinin, the parent compound of DHA, was isolated from the Artemisia annua plant by Chinese scientists in the 1970s. Traditional Chinese medicine had long recognized the medicinal properties of the Artemisia plant, and the isolation of artemisinin marked a significant breakthrough in the fight against malaria. Artemisinin was found to possess remarkable antimalarial activity, but it's poor solubility and short half-life limited its therapeutic potential. This prompted the development of its more potent and stable derivative, DHA.

The mode of action of DHA sets it apart from many other antimalarial drugs. Once administered, DHA undergoes rapid metabolism in the body, primarily in the liver, to form its active compound. DHA's mechanism of action mainly involves the generation of reactive oxygen species (ROS) within the malaria parasite-infected red blood cells. In the presence of iron, DHA's endoperoxide bridge undergoes reductive activation, producing highly reactive free radicals, which are toxic to the parasite. These free radicals alkylate critical parasite proteins, disrupt the parasite's cell membrane integrity, and cause damage to its biomolecules, leading to the destruction of the parasite.

DHA is known for its rapid onset of action and ability to reduce parasite biomass rapidly. This is particularly important in treating severe malaria, where prompt and effective response is crucial. When combined with a partner drug, DHA helps to achieve the dual goal of rapidly reducing parasitemia while also preventing the emergence of drug-resistant malaria strains. ACTs are now considered the first-line treatment for uncomplicated cases of malaria in many regions.

In addition to its antimalarial properties, DHA has also garnered attention for its potential applications in other diseases. Some studies have explored its efficacy against other parasitic infections, such as schistosomiasis, as well as its antiviral activities against diseases like hepatitis B.

The purity of our company's dihydroartemisinin supplement can reach 99%. Also, our prices are very competitive compared to other companies. If you want to know more, please contact Xi'an Sonwu Biotech Co. Ltd.

Buy Dihydroartemisinin

Xi’an Sonwu has rich experience in the global trade and health industry. Reputation-based quality first is the principle of Xi’an Songwu Company. Xi’an Sonwu strictly controls product quality, so the selection of materials starts with raw materials. Also, we handle every detail and minimize costs so that our clients can get the most cost-effective products. Based on these, customers have given high praise to our products. If you need dihydroartemisinin supplement, find Xi’an Sonwu Biotech Co. Ltd.

We completely make sure of the product’s quality, so samples can be supplied. Here is the quantity.

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Xi'an Sonwu not only can supply high-quality dihydroartemisinin powder but also supply its capsules.

So any customers could customize the capsules they want. And items below can be supplied.

Customized capsules shells (size, color, material)

Customized bottles(size, color, material, style)

Customized packaging(vacuum foil packaging, box, drum)

Customized label(paint film, matte film, optical mask)

How Is Dihydroartemisinin Made

Dihydroartemisinin (DHA) is obtained through a multi-step process from its natural precursor, artemisinin, which is extracted from the Artemisia annua plant. Here's a breakdown of the typical manufacturing process for dihydroartemisinin:

1. Plant Extraction: Artemisia annua plant leaves are harvested, typically during the flowering stage, to obtain the highest concentration of artemisinin. The plant material is then dried to remove moisture, and the leaves are separated from stems and other impurities.

2. Solvent Extraction: The dried artemisia leaves are subjected to a solvent extraction process. The most commonly used solvents are non-polar solvents like hexane or petroleum ether. These solvents effectively extract artemisinin from the plant material. The artemisinin-rich extract is obtained after filtration or centrifugation steps to separate the solid plant residues.

3. Crystallization and Purification: The artemisinin-rich extract undergoes a crystallization process to isolate and purify the artemisinin compound. Typically, a solvent like ethyl acetate or diethyl ether is used to dissolve the extract, followed by controlled cooling or evaporation to induce crystal formation. The crystals are then filtered or centrifuged, and the solid artemisinin is obtained.

4. Conversion to Dihydroartemisinin: Once the artemisinin is obtained, it can be converted into dihydroartemisinin through a chemical reduction process. One common method involves the use of sodium borohydride (NaBH4) as the reducing agent. The artemisinin is dissolved in a suitable solvent, such as methanol or ethanol, and then the NaBH4 is added gradually under controlled conditions. The reaction is typically carried out at a specific temperature and pH, with stirring. The reduction process converts the artemisinin into dihydroartemisinin.

5. Crystallization and Purification of DHA: The reduction product, dihydroartemisinin, is often obtained as a crude mixture. This crude mixture can be further purified by various methods such as recrystallization or chromatography. Recrystallization involves dissolving the crude product in a suitable solvent and then slowly cooling or evaporating the solvent to encourage the formation of pure dihydroartemisinin crystals. Chromatography techniques, such as column chromatography or preparative high-performance liquid chromatography (HPLC), can also be employed for purification, especially for large-scale production.

6. Drying and Formulation: Once the pure dihydroartemisinin is obtained, it is typically dried to remove any residual solvent and obtain a solid form. The dried dihydroartemisinin can then be further processed and formulated into various pharmaceutical products, such as tablets or capsules, for oral administration. It is often formulated in combination with other antimalarial drugs as part of artemisinin-based combination therapies (ACTs) to enhance treatment effectiveness and reduce the risk of drug resistance.

What Is the Mode of Action of Dihydroartemisinin

The mode of action of dihydroartemisinin (DHA) involves multiple steps, ultimately leading to the destruction of the malaria parasite. DHA is a potent antimalarial compound and is the active metabolite of artemisinin. It has a unique mechanism of action that sets it apart from many other antimalarial drugs. Here's a detailed explanation of how DHA works:

1. Activation and Conversion: When DHA is administered orally or intravenously, it undergoes rapid metabolism and is converted into its active form primarily in the liver. This active metabolite is responsible for the antimalarial activity of DHA.

2. Generation of Reactive Oxygen Species: DHA's effectiveness against malaria parasites relies on the presence of an endoperoxide bridge in its molecular structure. In the presence of iron, DHA undergoes a process called reductive activation, where it generates highly reactive oxygen species (ROS), such as free radicals, within the parasite's infected red blood cells. The exact mechanism of this activation process is not yet fully understood but is believed to involve the parasite's food vacuole and heme degradation products.

3. Alkylation of Biomolecules: The generated ROS react with various biomolecules, including proteins and lipids present in the parasites. These reactions lead to the alkylation (addition of an alkyl group) of critical parasite proteins. This process disrupts the normal function of these proteins, which are necessary for the survival of the parasite.

4. Membrane Disruption: DHA also affects the parasite's cell membrane integrity. It has a high affinity for membrane lipids and can intercalate into the parasite's lipid bilayer. This interaction leads to structural changes in the membrane, compromising its integrity and causing it to become more permeable. As a result, essential ions and molecules necessary for parasite survival leak out of the cell, disrupting its normal cellular functions.

5. Reactive Endoperoxide Moiety: DHA's endoperoxide bridge plays a crucial role in its mode of action. This unstable bridge is highly sensitive to reducing agents, mainly present in the malaria parasite-infected red blood cells. In the presence of these reducing agents, DHA's endoperoxide bridge undergoes a cleavage reaction, which generates toxic free radicals that damage the parasite's proteins, membranes, and other biomolecules.

6. Selectivity and Resistance: DHA's mode of action appears to be selectively toxic to malaria parasites, as its activation and subsequent ROS generation occurs primarily in the parasite-infected red blood cells and does not significantly affect human cells. However, there have been reported cases of resistance to artemisinin and its derivatives, including DHA. This resistance mechanism is still under investigation but is thought to involve altered drug targets, reduced drug activation, increased drug efflux, or enhanced DNA repair mechanisms within the parasite.

What Are the Side Effects of Dihydroartemisinin

Here are some of the possible side effects associated with dihydroartemisinin supplement:

1. Gastrointestinal Side Effects: The most common side effects of dihydroartemisinin are related to the gastrointestinal system. These can include nausea, vomiting, diarrhea, abdominal pain, and loss of appetite. These symptoms are usually mild and self-limiting, but in some cases, they can be more severe and require medical attention.

2. Central Nervous System Effects: Some individuals may experience dizziness, headaches, and general malaise while taking dihydroartemisinin. These effects are usually transient and resolve on their own. However, if these symptoms persist or worsen, it is advisable to consult a healthcare professional.

3. Allergic Reactions: Although rare, some individuals may develop an allergic reaction to dihydroartemisinin. Symptoms of an allergic reaction may include rash, itching, hives, swelling of the face, lips, tongue, or throat, and difficulty breathing. Any signs of an allergic reaction should be taken seriously, and immediate medical attention should be sought.

4. Liver Toxicity: In rare cases, dihydroartemisinin has been associated with liver toxicity. Symptoms can range from mild elevation of liver enzymes to severe liver injury. Individuals with existing liver conditions, such as hepatitis or cirrhosis, may be at a higher risk. Regular monitoring of liver function tests is recommended during dihydroartemisinin treatment, especially in individuals with underlying liver problems.

5. Hematological Effects: Dihydroartemisinin may cause changes in blood cell count. This can include a decrease in red blood cells (anemia), white blood cells (leukopenia), and platelets (thrombocytopenia). These effects are generally mild and reversible, but in rare cases, they can be more severe and require medical intervention.

6. Cardiovascular Effects: There have been occasional reports of cardiovascular effects associated with dihydroartemisinin, such as palpitations, rapid heart rate, and changes in blood pressure. These effects are usually transient and resolve without intervention. However, individuals with pre-existing cardiovascular conditions should exercise caution when taking dihydroartemisinin and consult with a healthcare professional if any concerning symptoms arise.

Factory

Xi'an Sonwu is located in a place with a beautiful natural environment, covering an area of 10,000 square meters. The factory has advanced production equipment, and the technical team is well-equipped, clean, and tidy, with sufficient stock. Under the leadership of the company, researchers insist on developing new products. The following is the testing environment of our laboratory, advanced testing equipment, and professional testers, with a strict attitude to providing valuable data for our products and providing our customers with a quality experience.

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In addition to guaranteeing product quality, the other most vital thing is clients can receive the goods smoothly. So, Xi'an Sonwu supplies all kinds of couriers according to different needs.

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FAQ

1. How to inquiry?

You can contact us by email, telephone number, or social media.

2. How to guarantee the quality of products?

Each batch needs to be tested so we can supply COA for customers. Additionally, our products pass the test: HPLC, UV, GC, TLC, etc. And we also cooperate with third parties, like, SGS.

3. How to pack and store the product?

Pack: Vacuum sealed foil packaging & Sealed export grade drum or pack according to customers' need

Storage: For a short time, you can keep it in a dry and cool place and make it avoid sunlight.

If you are interested in our company's dihydroartemisinin powder, please contact Xi'an Sonwu Biotech Co. Ltd.

Email: sales@sonwu.com

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