ALA Powder

What Is 5-aminolevulinic Acid

ALA powder supplements find applications in various fields, including medicine, biotechnology, and agriculture. ALA is a natural compound. This organic acid is an important part of the synthesis of heme, an essential building block of many essential proteins in the body.

At its heart is a small molecule consisting of a five-carbon chain with an amino group at one end and a carboxyl group at the other. The presence of these functional groups endows 5-ALA with specific chemical and biological activities that allow it to play an important role in various biological processes.

One of its most notable roles is its involvement in heme biosynthesis. In vivo, it acts as an intermediate in the heme synthetic pathway, providing the necessary building blocks for the production of the heme molecule. Heme is an important building block of many proteins, including hemoglobin, myoglobin, and various enzymes involved in energy metabolism and oxygen transport.

In addition to its role in heme synthesis, it has been extensively studied for its potential applications in medicine. Examples include photodynamic therapy (PDT) and diagnostic applications. When administered orally or topically, 5-ALA selectively accumulates in certain tissues or cells, such as cancer cells or precancerous lesions. When exposed to specific wavelengths of light, the accumulated 5-ALA undergoes a photochemical reaction and generates reactive oxygen species that damage target cells. When administered as a fluorescent marker, it can aid in the detection and visualization of abnormal tissue.

In addition, ALA has also shown potential in the field of agriculture. It has been studied as a plant growth regulator and stress protectant.

The purity of our company's 5-aminolevulinic acid can reach 99%. Also, our prices are very competitive compared to other companies. If you want to know more, please contact Xi'an Sonwu Biotech Co. Ltd.

5-aminolevulinic Acid Price

Xi’an Sonwu has rich experience in the global trade and health industry. Reputation-based quality first is the principle of Xi’an Songwu Company. Xi’an Sonwu strictly controls product quality, so the selection of materials starts with raw materials. Also, we handle every detail and minimize costs so that our clients can get the most cost-effective products. Based on these, customers have given high praise to our products. If you need ala capsules, find Xi’an Sonwu Biotech Co. Ltd.

We completely make sure of the product’s quality, so samples can be supplied. Here is the quantity.

Customers’ Good Comment

OEM Service

Xi'an Sonwu not only can supply high-quality ala powder, but also supply ala capsules.

So any customers could customize capsules they want. And items below can be supplied.

Customized capsules shells (size, color, material)

Customized bottles(size, color, material, style)

Customized packaging(vacuum foil packaging, box, drum)

Customized label(paint film, matte film, optical mask)

What Are the Health Benefits of 5-ALA

1. Diagnosis and treatment of cancer: One of the most important applications of 5-ALA is the diagnosis and treatment of various types of cancer. When administered to patients, 5-ALA selectively accumulates in cancer cells. This enables enhanced tumor detection and visualization during diagnostic procedures such as fluorescence-guided surgery and photodynamic therapy (PDT). In PDT, 5-ALA is used to induce photosensitivity in cancer cells, making them more susceptible to targeted damage when exposed to specific wavelengths of light.

2. Photoprotection: Another important benefit of 5-ALA is its photoprotective effect. When applied topically, 5-ALA has been shown to increase the production of endogenous antioxidants, such as bilirubin and heat shock proteins, which help protect the skin from the harmful effects of ultraviolet (UV) radiation. This property makes 5-ALA a potential ingredient in sunscreens and skin care products aimed at preventing sun damage.

3. Anti-inflammatory Effects: 5-ALA has been found to possess anti-inflammatory properties, which can be beneficial in various inflammatory conditions. It has been shown to inhibit the production of pro-inflammatory cytokines and reduce the activation of inflammatory pathways. This anti-inflammatory activity may have potential applications in the treatment of inflammatory skin disorders, such as psoriasis and atopic dermatitis.

4. Neuroprotective: Studies have shown that 5-ALA has neuroprotective properties. It has been shown to protect neurons from oxidative stress and inflammation, which have been linked to the development and progression of neurodegenerative diseases such as Alzheimer's and Parkinson's. By reducing oxidative damage and promoting cell survival, 5-ALA may have potential therapeutic applications in the field of neurology.

5. Wound Healing: 5-ALA has been studied for its role in wound healing. When applied topically, it can accelerate the healing process by promoting collagen synthesis, enhancing cellular proliferation, and improving angiogenesis (formation of new blood vessels). These effects contribute to faster wound closure and improved tissue regeneration, making 5-ALA a potential therapeutic option for chronic wounds and skin ulcers.

6. Antioxidant Properties: 5-ALA exhibits antioxidant activity, allowing it to scavenge free radicals and protect cells from oxidative damage. By reducing oxidative stress, 5-ALA may have potential benefits in preventing or mitigating the development of various chronic diseases, including cardiovascular diseases, diabetes, and age-related macular degeneration (AMD).

7. Agricultural Applications: Apart from its human health benefits, 5-ALA has been investigated for its potential application as a plant growth regulator and stress protectant. It has been shown to improve plant growth, enhance photosynthesis, and increase tolerance to environmental stressors such as drought, salinity, and heavy metals. This makes 5-ALA a promising tool for sustainable agriculture and crop production.

What Are the Sources of 5-aminolevulinic Acid

5-aminolevulinic acid (ALA) can be obtained from various natural and synthetic sources. While the compound is produced endogenously in the human body as part of the heme biosynthesis pathway, there are also external sources from which ALA can be derived.

1. Plant Sources: ALA can be found in various plants, particularly in those belonging to the family Amaranthaceae. One notable source is the plant species Amaranthus dubius, commonly known as Spleen amaranth or Red Spinach. Extracts from this plant can be used to obtain ALA, which can then be further processed for various applications.

2. Microorganisms and Bacteria: Certain microorganisms and bacteria have been identified as sources of 5-aminolevulinic acid. For instance, various strains of the bacteria Rhodobacter sphaeroides and Rhodobacter capsulatus have been used to produce ALA through fermentation processes. These bacteria naturally produce ALA as part of their metabolic pathways, which can be harnessed for commercial production.

3. Synthesis: Alternatively, 5-aminolevulinic acid can be produced synthetically through chemical synthesis. Chemical reactions, such as the condensation of glycine and succinyl-CoA or other appropriate precursors, can yield ALA. Synthetic production allows for greater control over the process, purity, and yield of ALA. Chemical synthesis is often employed for large-scale production to meet industrial or research needs.

4. Pharmaceutical Grade ALA: Pharmaceutical-grade ALA, sometimes referred to as ALA hydrochloride or ALA methyl ester hydrochloride, can be produced under Good Manufacturing Practices (GMP) guidelines. These highly controlled processes ensure the production of high-quality ALA suitable for specific medical or therapeutic applications, such as photodynamic therapy (PDT).

5. ALA Derivatives: There are also ALA derivatives available that can be converted into ALA within the body. For example, methyl-ester derivatives of ALA, such as methyl aminolevulinate (MAL), are used in PDT treatments for certain skin conditions and precancerous lesions.

What Are the Risks of Taking ALA

1. Gastrointestinal Disturbances: ALA supplementation can sometimes cause gastrointestinal side effects, such as nausea, vomiting, abdominal discomfort, and diarrhea. These symptoms are generally mild and transient, but some individuals may be more susceptible to these effects than others. Taking ALA with food or dividing the dose throughout the day may help reduce these gastrointestinal disturbances.

2. Hypoglycemia: ALA has the potential to lower blood sugar levels. While this effect can be beneficial for individuals with diabetes, it may pose a risk for those already taking medications to lower blood sugar levels, such as insulin or oral anti-diabetic drugs.

3. Allergic Reactions: In rare cases, some individuals may experience an allergic reaction to ALA. Symptoms can range from mild skin rashes and itching to more severe reactions like difficulty breathing, swelling of the face or throat, and anaphylaxis.

4. Photosensitivity: Photodynamic therapy (PDT) involving ALA can make the skin and eyes more sensitive to light. It is important to follow the specific guidelines provided by healthcare professionals to avoid prolonged exposure to sunlight or bright lights during and after PDT sessions to minimize the risk of sunburns or eye damage.

5. Interactions with Medications: ALA may interact with certain medications, including certain antibiotics, chemotherapeutic drugs, and antidiabetic medications. These interactions can alter the effectiveness or side effects of both ALA and the medications in question. It is essential to inform healthcare providers about all medications, supplements, or herbs being taken to assess potential interactions.

6. Hormonal Effects: ALA has been shown to influence hormone levels. It might affect the production and activity of certain hormones, such as thyroid hormones, leading to potential thyroid dysfunction. Individuals with thyroid disorders should consult with their healthcare provider before using ALA.

7. Precautions during Pregnancy and Breastfeeding: Limited research is available on the safety of ALA supplementation during pregnancy and breastfeeding. It is advisable for pregnant or breastfeeding individuals to consult with their healthcare provider before using ALA to evaluate potential risks and benefits.

Factory

Xi'an Sonwu is located in a place with a beautiful natural environment, covering an area of 10,000 square meters. The factory has advanced production equipment, and the technical team is well-equipped, clean, and tidy, with sufficient stock. Under the leadership of the company, researchers insist on developing new products. The following is the testing environment of our laboratory, advanced testing equipment, and professional testers, with a strict attitude to providing valuable data for our products and providing our customers with a quality experience.

Certificate

Packaging

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In addition to guaranteeing product quality, the other most vital thing is clients can receive the goods smoothly. So, Xi'an Sonwu supplies all kinds of couriers according to different needs.

FAQ

1. How to inquire?

You can contact us by email, telephone number, or social media.

2. How to guarantee the quality of products?

Each batch needs to be tested so we can supply COA for customers. Additionally, our products pass the test: HPLC, UV, GC, TLC, etc. And we also cooperate with third parties, like, SGS.

3. How to pack and store the product?

Pack: Vacuum sealed foil packaging & Sealed export grade drum or pack according to customers' need

Storage: For a short time, you can keep it in a dry and cool place and make it avoid sunlight.

If you are interested in our company's ala powder or ala capsule, please contact Xi'an Sonwu Biotech Co. Ltd.

Email: sales@sonwu.com

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