Home / Products / Nootropic / Details
video
Cladribine Powder

Cladribine Powder

Appearance: White crystalline powder
Specification: ≥99%
CAS: 4291-63-8
Molecular Formula: C10H12ClN5O3
Molecular Weight: 285.69
Shelf Life: 2 Years Proper Storage
Stock: Adequate Stock
Certificate: ISO,GMP, HACCP SGS
Service: OEM Service(Private Package)

Product Introduction

What Is The Origin of Cladribine

Cladribine Powder(CDA Powder), 2-chlorodeoxyadenosine (CDA), is a synthetic nucleoside analog drug used to treat certain blood cancers and multiple sclerosis. It was first synthesized in the 1970s by researchers at the Southern Research Institute in Birmingham, Alabama, United States.
 

Cladribine molecular formula

 

The development of cladribine was based on studying the chemical structure and properties of nucleosides, which are the building blocks of DNA and RNA. Nucleoside analogs are modified versions of natural nucleosides, and they can interfere with the normal function of DNA and RNA, leading to inhibition of cell division or cytotoxic effects on bad cells.

 

The researchers at the Southern Research Institute were investigating the potential antiviral properties of nucleoside analogs when they synthesized them. They found that it exhibited antiviral activity and prevented cytopathy properties. This discovery led to further studies on its efficacy and safety in treating lousy cell disease.

 

Since this raw powder assumes a significant part in all parts of clinical treatment and can successfully control cell lesions, Cladribine has become a hot-selling item among homegrown manufacturers, vast and small. When confronted with such countless decisions, the nature of the article has turned Xi'an Sonwu into not simply ready to give high-immaculateness crude powder but also the most favorable price.

 

Certificate of Analysis

ANALYSIS

SPECIFICATION

RESULT

Appearance

White crystalline powder

Conforms

Assay

99%

99.31%

Odor&Taste

Characteristic

Characteristic

Particle size

100% through 80 mesh

80 mesh

Ash

≤0.5%

0.09%

Loss on drying

≤2.0%

0.13%

Heavy metal

≤15ppm

4ppm

Cadmium(Cd)

≤0.5ppm

Complies

Lead(Pb)

≤1ppm

Complies

Arsenic(As)

≤2ppm

0.2ppm

Mercury(Hg)

Negative

Negative

Total bacteria count

≤1000cfu/g

71cfu/g

Fungi

≤100cfu/g

13cfu/g

Samonella

Negative

Negative

E. Coli

Negative

Negative

Conclusion

This product complies with international standards

 

Where To Buy CDA Powder

Sonwu has nearly 15 years of experience in international trade and possesses a high level of knowledge and technology to ensure proper pharmaceutical raw material quality and compliance with the production process standards.

Secondly, Xi'an Sonwu has vital research and development capabilities and innovative technologies with competitive advantages in the market. Finally, we have excellent customer service and support: we can provide our customers with timely and professional service and support so that customers get a better experience.

At the same time, communicate with customers regularly to ensure that the requirements of customers are met and provide customers with industry-related information and technical support. So look for Xi’an Sonwu Biotech Co. Ltd. when buying CDA.

 

Xi’an Sonwu ensures the product’s quality so samples can be supplied. Here is the quantity.

Form

Sample Amount

The Minimum of Quantity

Powder

50g

100g

 

Customers' Good Comment 

 

Cladribine Powder comment

 

OEM Service

Xi'an Sonwu cannot only supply high-quality Cladribine Powder But also supply its packaging customization.

So, any customers could customize the packaging they want. The items below can be supplied.

1. Customized bottles(size, color, material, style)

2. Customized packaging(vacuum foil packaging, box, drum)

3. Customized label(paint film, matte film, optical mask)

 

What Is The Mechanism of Action of Cladribine

The mechanism of action of cladribine involves its ability to interfere with the synthesis and repair of DNA through its incorporation into DNA strands. This disruption inhibits cell division and leads to the death of rapidly dividing cells, such as lesion cells and specific immune cells involved in autoimmune diseases like multiple sclerosis (MS).

 

CDA is also a nucleoside analog, specifically a deoxyadenosine analog. Nucleosides are the building blocks of DNA and RNA, and they consist of a sugar molecule (deoxyribose in the case of DNA) and a nitrogenous base (adenine, guanine, cytosine, or thymine). Cladribine is structurally similar to deoxyadenosine, except for a chlorine atom on the purine ring.

 

DNA damage

 

Once incorporated, cladribine triphosphate acts as a "masked chain terminator," preventing the further addition of deoxyribonucleotides to the growing DNA chain. Containing cladribine triphosphate leads to the termination of DNA strand elongation and inhibits the formation of DNA strands necessary for cell division and proliferation.

 

Furthermore, cladribine triphosphate inhibits the enzyme ribonucleotide reductase, which converts ribonucleotides to deoxyribonucleotides, essential precursors for DNA synthesis. By blocking ribonucleotide reductase, cladribine reduces the availability of deoxyribonucleotides needed for DNA replication and repair.

 

Cellular Health

 

In cancer treatment, cladribine's mechanism of action is especially relevant in rapidly dividing lesion cells. These cells rely more on DNA replication and repair processes, making them more susceptible to the disruption caused by CDA. As a result, cladribine induces apoptosis (programmed cell death) in lesion cells, ultimately reducing lesion cell growth.

 

What Is The Purpose of Cladribine

CDA has been approved in several countries for treating relapsing-remitting MS (RRMS) and active secondary progressive MS (SPMS). It is available orally, offering convenience and ease of administration to patients. Clinical studies have demonstrated that CDA significantly reduces the frequency of relapses, slows disability progression, and delays the accumulation of lesions in the CNS. It provides an important treatment option for MS patients, particularly those who may not tolerate or respond sufficiently to other disease-modifying therapies.

 

CDA treats specific blood lesion cells, such as hairy cell leukemia, chronic lymphocytic leukemia, and non-Hodgkin lymphoma, by inhibiting DNA synthesis and inducing apoptosis in rapidly dividing lesion cells. Additionally, it is used to manage multiple sclerosis by modulating the immune system and reducing inflammation in the central nervous system. The use of CDA should be determined by healthcare professionals based on individual patient characteristics and the specific indications for which it is approved.

 

Factory Environment

 

Cladribine Powder factory

 

Certificates

 

Cladribine Powder certificates

 

Packaging

 

Cladribine Powder packaging

 

Logistics

 

Cladribine Powder certificates

 

In addition to guaranteeing product quality, the other most vital thing is clients can receive the goods smoothly. So, Xi’an Sonwu supplies all kinds of couriers according to different needs.

 

courier

 

Why Choose Us

1. Best Quality

Choose the best raw material, and with the help of professional equipment and a research team, make sure to produce the best quality products.

2. OEM Service

Not only powder products, but also customized products can be supplied, like customized capsule shells, bottles, packaging, and labels. With rich experience in OEM, Xi’an Sonwu guarantees efficient delivery on time with high goods.

3. Good Service

With more than 10-year trade experience, Xi’an Sonwu can help customers solve all kinds of problems and supply professional service before and after sales, making sure customers receive goods smoothly.

 

If you want to know the Cladribine Powder, please get in touch with Xi'an Sonwu Biotech Co Ltd.

E-mail: sales@sonwu.com

Hot Tags: cladribine powder, China, suppliers, manufacturers, factory, wholesale, buy, price, bulk, pure, raw, supply, for sale, RAW Powders Noopept, NSI 189 Phosphate Powder, PRL 8 53 Powder, Sunifiram Powder, Pramiracetam Powder, Nefiracetam Powder

Send Inquiry

whatsapp

teams

E-mail

Inquiry

Bag