What Is Citicoline
Citicoline powder (cytidine 5'-phosphocholine) belongs to nucleotide derivatives. It can participate in the synthesis of lecithin in the human body, improve blood circulation in the brain, increase blood flow in the brain, improve the brain's metabolic function and help the recovery of brain function normal. The role of citicoline is mainly to improve the blood supply to the brain by improving microcirculation, and it has a specific effect on cerebral ischemia and cerebral infarction. It can protect the brain by eliminating oxygen-free radicals. Citicoline has a good impact on eliminating brain damage caused by calcium overload and improving brain function. It is clinically used to treat brain neurological sequelae caused by trauma or cerebrovascular accident. Citicoline can use for patients with traumatic brain injury, cerebral hemorrhage, or cerebral infarction.
Citicoline can also improve the brain's processing, improve brain function, can be used for the treatment of dementia, improve memory, improve calculation, improve the functional state of the brain, and so on. Generally speaking, it plays a role in brain protection by improving microcirculation, eliminating oxygen free radicals, and calcium overload to enhance brain function. With the broader application of citicoline, more and more citicoline suppliers appear on the market. Xi'an Sonwu is one of them, so if you need it, you can contact Xi'an Sonwu.
Certificate Of Analysis
Analysis | Specification | Results |
C14H26N4O11P2 Assay(on dried basis) | ≥99.0% | 99.15% |
Appearance | White crystalline powder, odorless | Conforms |
Solubility | Easily soluble in water, unsoluble in ethanol | Conforms |
Solution clarity and color | Solution should be clear and colorless | Conforms |
Related substances | 5’CMP 0.3% Simple impurity Total other impurity | 0.01% 0.03% 0.10% |
Chloride | 0.05% | Conforms |
Ammonium | 0.05% | Conforms |
Loss on drying | ≤6.0% | Conforms |
Heavy metals | 10.0ppm | Conforms |
Arsenide | 0.1ppm | Conforms |
Bacterial endotoxins | 0.3 EU/mg | Conforms |
Conclusion | The product conforms with standard | |
Where To Buy Citicoline
Xi'an Sonwu Biotech Co. ltd. is a factory that has rich experience in the global trade and health industry. Insisting on faith-based and quality first is our company's principle. Xi'an Sonwu strictly controls product quality, which means selection starts from raw materials. Besides, Xi'an Sonwu handles every detail and reduces costs to the maximum extent, so our customers can get cost-effective products. Based on the service and product quality, customers have given much good feedback to products. So look for Xi'an Sonwu Biotech Co. ltd. when buying citicoline.
Xi'an Sonwu ensures the product's quality and supplies the samples. Here is the quantity.
Citicoline Form | Sample Amount | MOQ |
Powder | 50g | 100g |
Bulk capsules | 200 capsule | 200 capsule |
Bottle capsules | 5 bottles | 5 bottle |
Customers' Good Comment
OEM Service
Xi'an Sonwu can supply high-quality powder and capsules.
So any customers could customize the capsules they want. And can provide the following items.
1. Customized capsules shells (size, color, material)
2. Customized bottles(size, color, material, style)
3. Customized packaging(vacuum foil packaging, box, drum)
4. Customized label(paint film, matte film, optical mask)
Mechanism Of Action Of Citicoline
Citicoline can protect cardiolipin and sphingomyelin, protect arachidonic acid content in phosphatidylcholine and phosphatidylethanolamine, partially restore phosphatidylcholine levels, and stimulate glutathione synthesis and glutathione reductase activity. It also increases neurotransmitter levels to enhance cellular communication and may help increase the number of other chemicals that carry messages to a person's brain.
1. For disturbance of consciousness and post-stroke hemiplegia
(1) Improving the brain waves of patients with impaired consciousness under anaerobic or hypoxic conditions.
(2) It can inhibit the cortical brain wave arousal response and muscle-evoked potential threshold increase caused by the stimulation of the cerebral cortex. It can also promote the function of the ascending reticular activation system and the pyramidal system, thereby improving the level of consciousness and motor function.
(3) For patients with cerebral circulation disorders, it can increase cerebral blood flow and reduce cerebral vascular resistance, thereby improving cerebral circulation. Specifically increasing blood flow in the brainstem.
(4) For patients with cerebrovascular diseases, the electromyogram shows that it can increase the muscles with a reduced maximum working capacity of paralysis, prolong fatigue under heavy load, and improve central motor dysfunction.
(5) Promote glucose uptake in the brain, Inhibits the accumulation of lactic acid, improve the decreased respiratory function of the mitochondria in rabbits with experimental cerebral infarction, and promote the biosynthesis of acetylcholine due to the reduction of glucose. Remove cerebral ischemia and increase dopamine.，metabolic turnover, inhibiting free fatty acids in the brain during cerebral ischemia, etc.
2. For pancreatitis
(1) Reduce pancreas and liver tissue necrosis and prolong survival. In addition, when this product is combined with Gabecil or Aprotinin, its effect is more substantial than that used alone.
(2) This product is easily absorbed by pancreatic membrane lipids during the recovery period of rats with acute experimental pancreatitis. Participates in the repair of pancreatic biofilm by promoting the restoration of pancreatic biofilm lecithin biosynthesis.
(3) It can inhibit the activity of lecithinase in human pancreatic juice and serum of patients with acute pancreatitis and impede the decomposition of lecithin.
What Is Citicoline Used For
1. Glaucoma
A clinical study found the neuroprotective effect of citicoline in its muscle against glaucoma. After ten days of treatment with citicoline at a dose of 1 g per day, test patients found significant improvements in all aspects of the visual field. These treatment effects last at least three months and can be sustained through retreatment. In a two-year longitudinal study, patients treated with citicoline at a dose of 500 mg per day for four-month cycles significantly reduced the rate of glaucoma progression by an average of -0.15 +/- 0.3 dB/year.
In an eight-year trial of citicoline in glaucoma, some patients had improved visual field after two months of treatment. Still, it deteriorated after a four-month washout and some patients combined. The effect of treatment is better. Overall, an extension of citicoline therapy to 8 years resulted in stabilization or improvement of glaucomatous visual dysfunction.
2. Amblyopia and Non-arterial Ischemic Optic Neuropathy
Citicoline powder may improve amblyopia's retinal and retroretinal visual pathways by stimulating the dopaminergic system. It has been shown to enhance contrast sensitivity, visual acuity, visually evoked responses, combined occlusion effects, Campos, etc. There is also another study showing the beneficial results of Citicoline in amblyopia. After 15 consecutive days of citicoline treatment for ten patients with amblyopia, the visual acuity of both eyes of the users improved by 1.4-1.5, while that of the control group was 0.4.
Citicoline also had positive effects in patients with non-arterial ischemic optic neuropathy. Observing the comparison of data before and after 60 days of citicoline treatment found that compared with before treatment,
visual acuity, graphic electroretinogram, and visually evoked potential data all improved.
3. Nervous System Diseases
Many experimental studies have demonstrated that citicoline can reduce infarct volume and cerebral edema, improving stroke models' protective effect and neurological deficit. In clinical trials, citicoline has been reported to have ameliorative effects on ischemic stroke. In a study of 30 Alzheimer's patients, treatment with citicoline for 12 weeks showed enhanced cognitive performance, more pronounced in patients with mild dementia. This cure also increases cerebral blood flow velocity and brain bioelectrical activity.
Citicoline may inhibit the deposition of beta-amyloid in treating Alzheimer's disease. The neurotoxic effects of β-amyloid play a significant role in the progression of Alzheimer's disease. The β-amyloid protein in the dissolved state can promote the growth of neurites in a short period and improve the survival rate of neurons. In contrast, the β-amyloid protein in the deposited form has the opposite effect on neurons, which can cause Alzheimer's disease. Similar pathological changes --- neurite shrinkage and neuronal degeneration.
Citicoline Indications
1. Mainly used for disturbance of consciousness after acute craniocerebral trauma and brain surgery.
2. Impairment of consciousness in the acute stage of cerebral infarction.
3. Use for ischemic cerebrovascular disease, vascular dementia, tinnitus, and nerve deafness.
4. It is also suitable for coma and disturbance of consciousness caused by acute poisoning, infection, and massive cerebral infarction.
5. It is helpful for the recovery of upper and lower extremity functions of patients with stroke sequelae and post-stroke hemiplegia. Mix with drugs that promote brain metabolism and cerebral circulation. But only within one year after the onset, and in the case of functional rehabilitation training and oral drug therapy, the lower limb hemiplegia is relatively mild.
6. Treated with proteolytic enzyme inhibitors in the following items.
Acute pancreatitis.
Acute exacerbation of chronic recurrent pancreatitis.
Postoperative acute pancreatitis.
Citicoline Side Effects
The side effects of citicoline can cause a lack of energy, fatigue, easy drowsiness, and weakness of limbs. Digestive dysfunction and indigestion may occur, but the situation needs to vary from person to person. During the period of taking medicine, you should avoid eating greasy food not to affect the efficacy of the treatment. Occasionally, symptoms cause shock, and attention should be observed after administration. If symptoms such as blood pressure drop, chest tightness, and dyspnea occur, they should stop administration immediately, and appropriate treatment should be carried out.
Factory
1. The inventory of Xi'an Sonwu Biotech Co., Ltd has consistently been sufficient because Xi'an Sonwu has a factory to produce, manufacture, and store products. Xi'an Sonwu's production department is orderly, clean, and tidy. Under Xi'an Sonwu, researchers can continuously develop high-quality new products.
2. There are strict requirements for the staffing of Xi'an Sonwu. To ensure that each product meets the testing standards, professionals provide uncompromising data support and after-sales service.
Certificate
Package
Logistics
In addition to guaranteeing products, the most important thing is to help customers receive the goods smoothly. Therefore, according to customers' needs in different countries, Xi'an Sonwu supplies all kinds of express delivery.
FAQ
If you are interested in citicoline powder, you can contact Xi'an Sonwu. Click the email to get in touch with the best citicoline price and high-quality manufacturer.
Email:sales@sonwu.com
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