Abaloparatide Powder

Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of abaloparatide powder in China. We warmly welcome yuo to wholesale bulk abaloparatide powder for sale here from our factory. Quality products and reasonable price are available.

What Is Abaloparatide

Abaloparatide powder is a medication used for the treatment of osteoporosis in postmenopausal women at high risk of fractures. It is a synthetic peptide analog of human parathyroid hormone-related protein (PTHrP) and works by stimulating bone formation and reducing bone resorption, ultimately increasing bone mass and strength.

Osteoporosis is a condition characterized by low bone density and increased risk of fractures. It primarily affects postmenopausal women due to hormonal changes that occur after menopause. Estrogen levels decrease, leading to accelerated bone loss and deterioration. Osteoporotic fractures, particularly of the spine, hip, and wrist, can result in significant pain, disability, and a decreased quality of life.

It is specifically indicated for postmenopausal women at high risk of fracture. This includes women with a history of osteoporotic fracture, those with multiple risk factors for fracture, or those who have failed or are intolerant to other available osteoporosis therapies.

The mechanism of action of its involves binding to and activating the parathyroid hormone 1 receptor (PTH1 receptor) on osteoblasts and osteocytes, which are cells involved in bone synthesis and remodeling. By activating the PTH1 receptor, abaloparatide stimulates bone formation, enhances the differentiation and maturation of osteoblasts, and increases bone mineral density (BMD).

In addition to stimulating bone formation, it indirectly inhibits bone resorption. It reduces the production of receptor activator of nuclear factor kappa-B ligand (RANKL), a signaling molecule that promotes the formation and activation of osteoclasts. Osteoclasts are responsible for breaking down and removing old bone tissue. By inhibiting bone resorption, it helps maintain bone mass and prevent further bone loss.

Furthermore, it activates the Wnt signaling pathway, which plays a crucial role in regulating bone development and remodeling. Wnt signaling promotes the proliferation and differentiation of osteoblasts, leading to increased bone formation.

The purity of our company's abaloparatide supplement can reach 99%. Also, our prices are very competitive compared to other companies. If you want to know more, please contact Xi'an Sonwu Biotech Co. Ltd.

COA

Tymlos Cost

Xi’an Sonwu has rich experience in the global trade and health industry. Reputation-based quality first is the principle of Xi’an Songwu Company. Xi’an Sonwu strictly controls product quality, so the selection of materials starts with raw materials. Also, we handle every detail and minimize costs so that our clients can get the most cost-effective products. Based on these, customers have given high praise to our products. If you need abaloparatide supplement , find Xi’an Sonwu Biotech Co. Ltd.

We completely make sure of the product’s quality, so samples can be supplied. Here is the quantity.

Customers' Good Comment

OEM Service

Xi'an Sonwu not only can supply high-quality abaloparatide powder, but also supply customized packaging.

So any customers could customize packaging they want. And items below can be supplied.

1. Customized packaging(vacuum foil packaging, box, drum)

2. Customized label(paint film, matte film, optical mask)

What Is the Mechanism of Action of Abaloparatide

Abaloparatide, the active ingredient in Tymlos, is a synthetic peptide analog of human parathyroid hormone-related protein (PTHrP). Its mechanism of action involves the regulation of bone formation and resorption, ultimately leading to increased bone mass and improved bone strength. Here is a detailed explanation of the mechanism of action of abaloparatide:

1. Activation of PTH1 Receptor: It acts as an agonist at the parathyroid hormone 1 receptor (PTH1 receptor) on osteoblasts and osteocytes. The PTH1 receptor is predominantly expressed in bone cells and plays a crucial role in mediating the effects of parathyroid hormone (PTH) and PTHrP on bone.

2. Stimulation of Osteoblast Activity: Binding of abaloparatide to the PTH1 receptor leads to activation of intracellular signaling pathways, including cyclic adenosine monophosphate (cAMP) and protein kinase A (PKA) pathways. This activation stimulates osteoblasts, which are responsible for bone formation.

3. Increased Bone Formation: It promotes the differentiation and maturation of osteoblasts, leading to increased bone formation. It enhances the synthesis of collagen and other bone matrix proteins, promoting the deposition of new bone tissue.

4. Inhibition of Osteoblast Apoptosis: It reduces osteoblast apoptosis (programmed cell death), thereby prolonging the lifespan of osteoblasts. This allows for sustained bone formation activity and contributes to the accumulation of bone mass.

5. Suppression of Osteoclast Activity: It indirectly influences osteoclasts, the cells responsible for bone resorption. It inhibits the production of the receptor activator of nuclear factor kappa-B ligand (RANKL) by osteoblasts and osteocytes. RANKL is a signaling molecule that promotes the differentiation and activation of osteoclasts. By reducing RANKL expression, abaloparatide indirectly suppresses osteoclast activity and bone resorption.

6. Enhanced Wnt Signaling: It also stimulates the Wnt signaling pathway, which plays a crucial role in bone formation and remodeling. Activation of Wnt signaling promotes the proliferation and differentiation of osteoblasts, leading to increased bone mass.

7. Increased Bone Strength: Through its effects on bone formation and resorption, it improves the overall quality and strength of bone. It increases both cortical (outer) and trabecular (inner) bone density, making the bone more resistant to fractures.

What Are the Negative Side Effects of Tymlos

1. Orthostatic hypotension: Some individuals may experience orthostatic hypotension while using Tymlos. Orthostatic hypotension refers to a sudden drop in blood pressure upon standing up or changing positions. Symptoms may include dizziness, lightheadedness, or feeling faint. Patients should be cautious when transitioning from lying down or sitting to standing to minimize the risk of falls or injury. It is advisable to get up slowly and hold onto something for support if needed.

2. Nausea: Nausea is another potential side effect of Tymlos. Some individuals may experience feelings of queasiness or an upset stomach. Taking Tymlos with food may help alleviate these symptoms. If nausea persists or becomes bothersome, it is recommended to consult a healthcare professional.

3. Headache: Headaches have been reported as a side effect of Tymlos. These headaches can vary in intensity and may be temporary or recurring. If headaches become severe or persistent, it is advisable to seek medical attention for further evaluation and management.

4. Dizziness: Some individuals taking Tymlos may experience dizziness. This symptom can be accompanied by a feeling of lightheadedness or a sensation of unsteadiness. Patients should avoid activities that require alertness or coordination if they experience dizziness while using Tymlos.

5. Hypercalciuria: Tymlos may increase the levels of calcium in the urine, a condition known as hypercalciuria. This side effect may lead to an increased risk of developing kidney stones. Adequate fluid intake is important to help minimize the risk of kidney stone formation. If individuals experience symptoms such as severe abdominal or back pain, blood in the urine, or difficulty urinating, they should seek medical attention promptly.

6. Hypercalcemia: In rare cases, Tymlos can lead to high levels of calcium in the blood, a condition called hypercalcemia. Symptoms of hypercalcemia may include excessive thirst, frequent urination, constipation, abdominal pain, muscle weakness, confusion, or fatigue. Regular monitoring of serum calcium levels is recommended during treatment with Tymlos to detect and manage this condition promptly.

What Is the Difference Between Abaloparatide and Teriparatide

Abaloparatide and teriparatide are both medications used for the treatment of osteoporosis, particularly in postmenopausal women at high risk of fractures. Although they have similarities in their mechanism of action and indications, there are some differences between these two drugs. Here is a detailed comparison of abaloparatide and teriparatide:

1. Chemical Structure: Abaloparatide and teriparatide are synthetic analogs of human parathyroid hormone-related protein (PTHrP) and human parathyroid hormone (PTH), respectively. It is a 34-amino acid peptide, while teriparatide consists of the first 34 amino acids of intact PTH.

2. FDA Approval: Abaloparatide supplement was approved by the U.S. Food and Drug Administration (FDA) in 2017 for the treatment of postmenopausal women with osteoporosis at high risk of fracture. Teriparatide, on the other hand, was approved earlier in 2002 for the treatment of osteoporosis in both men and postmenopausal women at high risk of fracture.

3. Dosage and Administration: It is administered as a daily subcutaneous injection at a dose of 80 mcg. Teriparatide is also given as a subcutaneous injection, but the recommended dose is 20 mcg once daily. Both drugs are self-administered by patients after receiving proper training.

4. Duration of Treatment: The duration of treatment differs for abaloparatide and teriparatide. AIt is recommended for a treatment duration of 18 months. On the other hand, teriparatide is typically used for a maximum of 24 months due to concerns about potential bone tumors associated with long-term use.

5. Efficacy: Both abaloparatide and teriparatide have been shown to increase bone mineral density (BMD) and reduce the risk of fractures in clinical trials. However, direct head-to-head studies comparing the efficacy of abaloparatide and teriparatide are limited. In separate clinical trials, abaloparatide demonstrated a significant reduction in the risk of vertebral and non-vertebral fractures compared to placebo. Teriparatide has also been shown to reduce the risk of vertebral and non-vertebral fractures when compared to placebo.

6. Side Effects: The side effects of abaloparatide and teriparatide are generally similar. Both medications can cause dizziness, orthostatic hypotension (low blood pressure upon standing), nausea, headache, and injection site reactions. Additionally, both drugs carry a black box warning regarding the risk of osteosarcoma, a rare bone cancer. However, it is important to note that the clinical relevance of osteosarcoma risk in humans, especially with short-term use, is still not fully understood.

7. Long-Term Safety: Due to the risk of osteosarcoma, the long-term safety profile of both abaloparatide and teriparatide is an area of ongoing monitoring and investigation. Close monitoring and adherence to treatment guidelines are recommended for patients receiving these medications.

8. Cost: The cost of abaloparatide and teriparatide can vary depending on the country, healthcare system, and insurance coverage. Generally, teriparatide has been available for a longer period of time and may have more generic alternatives, which can potentially reduce the cost compared to abaloparatide.

Factory

Xi'an Sonwu is located in a place with a beautiful natural environment, covering an area of 10,000 square meters. The factory has advanced production equipment, and the technical team is well-equipped, clean, and tidy, with sufficient stock. Under the leadership of the company, researchers insist on developing new products. The following is the testing environment of our laboratory, advanced testing equipment, and professional testers, with a strict attitude to providing valuable data for our products and providing our customers with a quality experience.

Certificate

Packaging

Recent Logistics Record

In addition to guaranteeing product quality, the other most vital thing is clients can receive the goods smoothly. So, Xi'an Sonwu supplies all kinds of couriers according to different needs.

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FAQ

1. How to inquiry?

You can contact us by email, telephone number, or social media.

2. How to guarantee the quality of products?

Each batch needs to be tested so we can supply COA for customers. Additionally, our products pass the test: HPLC, UV, GC, TLC, etc. And we also cooperate with third parties, like, SGS.

3. How to pack and store the product?

Pack: Vacuum sealed foil packaging & Sealed export grade drum or pack according to customers' need

Storage: For a short time, you can keep it in a dry and cool place and make it avoid sunlight.

If you are interested in our company's abaloparatide powder, please contact Xi'an Sonwu Biotech Co. Ltd.

Email: sales@sonwu.com

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