What is Tianeptine Sodium
Tianeptine Sodium is an antidepressant medicine discovered in the 1960s by the French Society of Medical Research. It is mainly used in the treatment of major depressive disorders including anxiety, asthma, and many other syndromes. There are various other names by which tianeptine sodium is called stablon, coaxial and tatinol. Tianeptine is a prescription drug used for depression in some European, Asian, and Latin American countries. It is not approved for use in the US.
Tianeptine affects brain chemicals. It seems to affect mood when used in low doses. In higher doses, it works like an opioid and can cause addiction and other serious side effects. It can also cause withdrawal. So must be carful when pure tianeptine sodium is used.
Benefits of Using Tianeptine Sodium
In those countries where it is approved, tianeptine is mainly used for depression and anxiety disorders. It can be used for the following symptoms.
Depressive Symptoms
Tianeptine was as effective as several classical antidepressants in patients with major depression, dysthymia or adjustment disorder. Also, extended treatment with tianeptine decreased the incidence of relapse/recurrence of depression.
According to the related research, in a clinical trial on 18 people with Parkinsons’ disease (PD), tianeptine decreased the severity of depression and also improved the quality of life in these patients.
In rats, tianeptine helped with drug-induced seizures and learning and memory impairment. This study shows that tianeptine may benefit depressive patients with epilepsy.
Tianeptine may have additional potential for a specific subgroup of depressed patients like the elderly and those with chronic alcoholism due to a relative lack of sedative, anticholinergic and cardiovascular adverse effects. Tianeptine helps depressive symptoms in postmenopausal women and may decrease appetite. However, it does not affect weight long-term and should not be used for obesity treatment.
Anxiety, Stress, and PTSD Symptoms
In a clinical trial on 164 elderly, depressive patients, a drug regimen of tianeptine or escitalopram improved anxiety symptoms and subjective and objective neurocognitive functions.
In another trial on 20 panic disorder patients, tianeptine appeared to reduce their reaction to panic challenge.
In a study on 90 people, tianeptine (at 37.5 mg dosage) was effective in treating post-traumatic stress disorder (PTSD) patients when compared to the control.
In rats with predator-caused posttraumatic stress disorder (PTSD), tianeptine most effectively prevented the effects of psychosocial stress.
Asthma
During asthma attacks, catecholamines and free serotonin are found circulating in the blood. Tianeptine decreases free serotonin in the blood by enhancing serotonin uptake by platelets and serotonergic brain cells. Free serotonin is taken up by lung cells, which induces bronchial contraction (via 5-HT(3) and 5-HT(4) postsynaptic receptors).
In a clinical trial on 25,000 asthmatic patients, treatment with tianeptine provoked an abrupt disappearance of asthma attacks. In another trial on 69 asthmatic children, tianeptine improved lung function and reduced free serotonin levels.
Irritable Bowel Syndrome
Serotonin plays an important role in the nervous system of the intestinal tract, where it controls intestinal secretions and the movement of digestive material. Increased serotonin causes elevated secretions and movement, which contributes to pain, bloating and diarrhea in patients with irritable bowel syndrome (IBS).
Tianeptine decreases serotonergic activity, and thus improves the symptoms associated with IBS and nonulcer dyspepsia.
In a clinical trial on 122 people, tianeptine was effective as the standard drug (amitriptyline) for treating IBS-D (irritable bowel syndrome with diarrhea). In another trial on 100 people with either IBS-D or IBS-C (irritable bowel syndrome with constipation), tianeptine improved the symptoms and quality of life in both groups, especially IBS-C.
Mechanism of Action
Previous studies have owed its action to its effect on the serotonin receptor, dopamine (D2/3) receptors, and glutamate receptors as discussed below:
Tianeptine has challenged the monoaminergic hypothesis of depression, as well as the widely supported monoaminergic mechanisms whereby the action of most known antidepressants have been explained.
Specifically, this drug is thought to persistently alter glutamate receptor bursting of the hippocampal CA3 commissural associational synapse. Current research suggests that tianeptine produces its antidepressant effects through the modulation of glutamate receptor activity (for example, AMPA receptors and NMDA receptors) and affect the release of brain-derived neurotrophic factor (BDNF), which impacts neural plasticity. More recent studies by support the role of tianeptine in the modulation of glutaminergic activity in the amygdala, the emotional region of the brain associated with memories.
Tianeptine reduces the hypothalamic-pituitary-adrenal response to stress, and thus prevents stress-related behavioral issues. In rodents, the stress of acute restraint increases extracellular levels of glutamate in the basolateral amygdala an effect that was inhibited by tianeptine. Interestingly, the SSRI fluoxetine increased extracellular glutamate levels in the basolateral amygdala regardless of stress conditions. These data demonstrate that the mechanism of action of tianeptine is distinct from SSRIs and support the hypothesis that the mechanism of action of tianeptine relates to alteration of glutaminergic activity in the amygdala and the hippocampus.
In addition to the above mechanisms, tianeptine is a unique antidepressant and anxiolytic medication that stimulates the uptake of serotonin (5-hydroxytryptamine; 5-HT), and 5-hydroxyindoleacetic acid (5-HIAA) in brain tissue.
Although the monoaminergic neurotransmitters serotonin (5-HT), noradrenaline (NA) and dopamine (DA) are proven to be related to the occurrence of depressive disorders, it is now recognized that monoamine deficits are not sufficient to explain the mechanism of action of antidepressant medications.
Potential Side Effects
Being a nootropic, Tianeptine Sodium is generally safe with no toxicity to human beings. There have been very few reports of Tianeptine causing side effects when used within the recommended dosage range of 12.5mg to 25mg per day. Most cases of notable side effects have been reported in users sensitive to Tianeptine, or in cases where significantly high doses are administered.
Common side effects that have been reported include dry mouth, irregular sleep patterns, dizziness, constipation, and nausea. These, however, can be easily reversed by reducing the dosage or temporarily stopping the use of this drug. In cases where the side effects persist or escalate, be sure to contact your doctor immediately for intervent.
While tianeptine is available by prescription in certain countries, it has a risk of misuse and abuse. Taking high doses of tianeptine can cause drowsiness, confusion, difficulty breathing, coma, and death. Long-term use can cause dependence and withdrawal.
Where to Buy Tianeptine Sodium
Tianeptine is a drug with antidepressant and anti-anxiety properties, which is primarily used to improve the symptoms of major depressive disorder (MDD). It has also been used to help irritable bowel syndrome and asthma.
Tianeptine is available in some European, Asian, and South American countries. However, it is banned in the United Kingdom, and is not medically prescribed by doctors in the United States due to concerns over its potential for abuse and addiction. However, Tianeptine has challenged the monoaminergic hypothesis of depression, as well as the proposed monoaminergic mechanisms whereby the action of most known antidepressants was explained. Therefore, nowadays it 's widely bought by people who suffered diseases related to MDD.
Tianeptine Sodium is the hot product of Xi'an Sonwu Biotech Co., Ltd., a professional Chinese tianeptine sodium manufacturer and product supplier, which focuses on the development, research and production of API, food additives, plant extract, and other raw ingredients of health care products. You can buy a variety of products from multiple categories, including tianeptine sodium for sale, which you can get for a reasonable price.
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References:
https://drugs.selfdecode.com/blog/tianeptine/
https://healthpurelives.com/all-you-need-to-know-about-tianeptine-sodium-and-its-uses/
https://www.webmd.com/vitamins/ai/ingredientmono-1587/tianeptine
https://nootropicsrevealed.com/tianeptine-sodium/