Best Creatine Monohydrate
99 creatine monohydrate powder is an endogenous nitrogen-containing compound that can increase the storage of creatine phosphate to help produce ATP. Therefore, creatine can help the brain obtain sufficient energy for optimal human brain operation, which plays a key role. As a pharmaceutical raw material and health product additive, it can also be used to prevent the development of factors that cause muscle fatigue, lessen fatigue and tension, improve physical fitness, speed up protein synthesis in the body, strengthen muscles, increase muscle elasticity, lower cholesterol, blood lipids, and blood sugar levels, improve muscular dystrophy in middle-aged and older adults, and postpone aging.
In daily life, there are three primary sources of creatine. First, creatine can be produced and synthesized in the human body through a two-step reaction in the liver and brain. Second, it can be ingested through daily dietary sources (such as red meat and seafood). Finally, it can also be obtained through commercially produced creatine. Creatine monohydrate has been acclaimed as one of the most well-liked and successful nutritional supplements over the past ten years. Its standing is sufficient to keep up with protein goods, and it has consistently been listed among the "best-selling supplements." It is regarded as a "must-use" supplement for bodybuilders and is frequently used by players in other sports, like basketball and football, who wish to increase their stamina and strength.
Creatine is not an illegal drug and is naturally found in many foods. Therefore, creatine is not prohibited by any sports organization. If you are interested in this supplement and want pure creatine powder, you can contact Xi'an Sonwu online anytime.
What Type Of Creatine Is Best For The Brain
Creatine is a popular supplement known for its potential benefits in enhancing physical performance and muscle strength. However, when it comes to the brain specifically, research on the cognitive effects of creatine remains relatively limited. The most extensively researched and often utilized form of creatine is creatine monohydrate. Its impact on athletic performance, muscle strength, and potentially cognitive function have been extensively studied. Some studies suggest that creatine supplementation positively affects cognitive tasks that require short-term memory concentration and reduces mental fatigue.
1) Cognitive ability
Cognitive functions include attention, executive functions, decision-making, memory, reasoning, perception, language, creativity, and knowledge. As aging progresses, cognitive functions will also decline significantly, with attention, memory, and reaction ability being the most obvious. Through animal studies, creatine has been identified as necessary in high-energy cognitive tasks involving learning and memory. For example, after ingesting creatine, aged C57Bl/6J mice improved their object recognition memory and were more inclined to explore new environments. In addition to animal studies, more human clinical studies are also being conducted. However, the results across studies are inconsistent, with some showing improvements in cognitive function and others showing no benefit. For example, creatine supplementation (20 g/day for seven days) in healthy elderly participants improved their memory. In contrast, in young adults, creatine supplementation (0.03 g/kg/day; approximately 2.2 g/day) for six weeks did not significantly improve their cognitive function.
2) Insufficient brain energy
Decreased sleep quality and reduced deep sleep time are also significant problems accompanying aging. Insufficient brain energy caused by sleep deprivation, hypoxia, and mental exhaustion is particularly detrimental to older people's health in all areas, and creatine supplementation has been shown to repair the damage. For example, creatine supplementation (20 g/day for seven days) in young, healthy individuals reduced omission errors on a continuous performance test during acute hypoxia. Additionally, after performing lengthy computing tasks, five consecutive days of creatine supplementation reduced mental fatigue in young, healthy adults.
3) Mood disorders
The leading causes of disability worldwide are mood disorders such as major depressive disorder, bipolar illness, anxiety disorders, etc. The COVID-19 epidemic has caused an increase in mental disorders among older people during the past few years. It has become an essential factor threatening the longevity and quality of life of older people worldwide. Research suggests that creatine concentrations within the frontal cortex may be related to symptoms of mood disorders, with higher creatine concentrations associated with lower levels of depression, anxiety, or stress. For this reason, increasing creatine levels in the prefrontal cortex may help relieve some symptoms of depression and anxiety. For example, in 25 depressed women, supplementing with 5 g of creatine daily for eight weeks synergized the antidepressant effects of the drug (selective serotonin reuptake inhibitor escitalopram).
4) Neurodegenerative diseases
Neurodegenerative diseases are disabling diseases that progress slowly and are also one of the types of elderly systemic infections caused by aging. Because the creatine phosphate system plays a critical role in many cellular and energy pathways, some have speculated that creatine supplementation may be an effective strategy to slow the progression of neurodegenerative diseases. No experimental evidence exists that creatine supplementation can improve amyotrophic lateral sclerosis and conditions other than muscular dystrophy (Alzheimer's disease, Parkinson's disease, etc.). In a trial of creatine supplementation in patients with amyotrophic sclerosis, researchers found that creatine supplementation prevented neuronal loss, reduced cortical glutamate concentrations (which play a role in neuronal degeneration and death), and prolonged Mice survival rate. These findings may provide some evidence for a potential mechanistic role of how creatine may contribute to increased longevity and improved athletic performance.
How Does Creatine Work In The Brain
The effect of creatine on improving our brain health is affected by many factors, and its impact on people of different ages and genders is not the same or even very different. Also, there is a limit to how efficiently our brains can absorb external creatine. So, how does creatine work in the brain?
Creatine enters the cell membrane through the blood-brain barrier, CRT in neurons, and oligodendrocytes, where it helps maintain glycolytic ATP levels. Creatine enters the mitochondria through MtCK and converts ATP to PCr through oxidative phosphorylation. ATP and PCr can be recycled back to the cell membrane from mitochondria to regulate energy demand, promoting brain energy metabolism. One of the critical obstacles is the creatine transporter (CT1) on our blood-brain barrier. Dietary creatine and creatine synthesized in the liver are transported across the blood-brain border to the brain via creatine transporters. CT1 is a sodium- and chloride-dependent multi-channel membrane protein. CT1 at the blood-brain barrier is the main pathway and is crucial in regulating creatine levels. Whether its function is normal or not is closely related to the brain's creatine intake. , which also provides a theoretical basis for the damage of blood-brain barrier function leading to cognitive function impairment. However, CT1 is not an abundant component of blood-brain barrier capillaries; therefore, the adult central nervous system cannot uptake creatine from the circulation. In addition, the function of CT1 will be down-regulated due to exogenous creatine intake, which may lead to possible brain resistance or a weakened response to creatine after long-term consumption. That also explains why only high-dose, long-term creatine supplementation significantly benefits brain function.
Additionally, brain creatine levels can be increased by consuming some of the precursors of creatine, such as guanidinoacetic acid and cyclocreatine. These precursors can be absorbed into the brain through transporters other than CT1. They can be methylated into creatine at any time, thus avoiding the limitation of creatine absorption caused by the quantitative and functional limitations of CT1 itself. However, there is also evidence that both during development and in adulthood, the two enzymes required for creatine synthesis (L-arginine, glycine aminotransferase, and guanidinoacetate N-methyltransferase) are only present in widely expressed in brain blasting cells, which further limits the brain's ability to absorb creatine and its precursors from the circulation.
Is It Safe To Stack Creatine
Consider your specific goals and individual needs when stacking creatine monohydrate with other supplements. However, a few joint supplements are often stacked with creatine monohydrate for enhanced benefits.
Protein Powder: Protein is essential for recovery and muscle growth. Combining creatine monohydrate with a protein powder can help support muscle development and optimize performance.
Branched-Chain Amino Acids (BCAAs): BCAAs, such as leucine, isoleucine, and valine, are crucial for muscle repair and recovery. Adding BCAAs to your creatine monohydrate stack can further support muscle growth and reduce exercise-induced muscle damage.
Beta-Alanine: Beta-alanine can enhance exercise performance and increase endurance. Combining beta-alanine with creatine monohydrate may have additive effects on muscular strength, power, and endurance.
Citrulline Malate: Citrulline malate is a compound that can increase nitric oxide production, leading to enhanced blood flow and improved exercise performance. Stacking citrulline malate with creatine monohydrate may support better workouts and enhance muscle growth.
Creatine monohydrate can be used as a food additive, cosmetic surfactant, feed additive, beverage additive, pharmaceutical raw material, and health product additive. It can also be directly made into capsules for oral administration. If you want to know about creatine manufacturers, you can contact Xi'an Sonwu. Get high-quality creatine supplements with just a click of your email.
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