What is spermidine?
Spermidine HCL Powder is made of Spermidine, which is a polyamine, meaning it has two or more primary amino groups. It is naturally occurring and is widely encountered in ribosomes and living tissues. It plays a critical role in cell function and survival. The spermidine levels in human’s body begin to decline with age. While Spermidine has the potential to stop the natural process of cellular aging and to fight diseases that are associated with aging. That's why spermidine supplementation is important, especially if people get older because our body does not produce enough of it.
Where does spermidine come from?
Spermidine was first discovered in 1678 by Dutch scientist Anton Van Leeuwenhoek in a sample of human semen. Shortly after, spermidine was discovered in human sperm. In the body, spermidine is created from its precursor putrescine. It is the precursor for another polyamine called spermine, which is also important for cellular function.
Spermidine and putrescine are known to stimulate autophagy, which is a system that breaks down waste inside cells and recycles cellular components. It is an important quality control mechanism for the mitochondria, the powerhouses of our cells. Autophagy allows damaged or defective mitochondria to be broken down and disposed of. The disposal of mitochondria is more tightly controlled than was before believed. Polyamines can bind to many different types of molecules making them very useful. They support processes, including cell growth, DNA stability, cell proliferation, and apoptosis. It also appears that polyamines function in a similar way to growth factors during cell division. This is why putrescine and spermidine are important for healthy tissue growth and function.
What's more, It was discovered that this great vital substance can actually be found in all living beings. Spermidine even appears in plant foods, such as mushrooms, legumes, aged cheese, soybean, chickpea, green peas, mango, whole grain products, and wheat germ. Soy contains a particularly high level of this valuable substance and is therefore used to obtain pure spermidine for dietary supplements. However, these natural sources are generally very low in spermidine concentration, 1%, 2%, or even lower. Therefore, Xi'an Sonwu, the high-quality spermidine hcl powder supplier, is your best choice if you want to increase your spermidine levels.
What is spermidine used for?
Spermidine plays an essential role in organisms, like humans and even plants. One of spermidine's biggest and most profound functions, from which other functions stem from, is the ability to counteract aging and promote autophagy.
Our bodies are made up of cells. As we age, our cells age as well. When these cells become old or damaged, it can cause build up of dead or toxic organelle matter in our bodies, potentially leading to age-related disease and injury. Spermidine in our cells optimizes autophagy and cellular renewal.
Autophagy is a cellular recycling routine that can help cells remove waste and unwanted components. It is the ultimate recycling system of the cell. The word comes from ancient Greek and means "eating of self". Although its name might sound harmful, it appears to have longevity-promoting effects.
Here are some benefits of autophagy:
-Removing toxic proteins from the cells that may be a cause of some age-related diseases;
-Recycling residual proteins;
-Providing energy and building blocks for cells;
-Promoting regeneration and healthy cells, etc.
Autophagy is an important maintenance and repair mechanism, especially in the context of aging, which have aroused the interests of a number of researchers who are working on triggering or increasing its activity in cells.
Spermidine is also known to regulate various cellular processes including: DNA stability, cellular growth, cellular differentiation, apoptosis (Which is cellular death as a normal part of growth and development in organisms)
What's the benefit?
Spermidine & autophagy
As mentioned before, spermidine triggers autophagy.
The ability of spermidine to trigger autophagy is thought to be the main mechanism by which it appears to slow down aging and support longevity. Spermidine also plays a central role in a number of important biological processes, including aspartate receptors, cGMP/PKG pathway activation, nitric oxide synthase, and cerebral cortex synaptosome activity.
Spermidine & Anti-inflammatory properties
Although the primary way in which spermidine appears to support longevity is via autophagy, there is also evidence that it supports health and longevity in other ways. Some studies suggest that it has anti-inflammatory properties and is involved in lipid metabolism, cell growth and proliferation, and programmed cell death, which is known as apoptosis.
It is widely accepted that while inflammation plays a helpful role in wound healing and repelling invading pathogens, the persistent inflammation associated with aging, often called inflammaging, is harmful. Chronic inflammation prevents healthy tissue regeneration, causes immune cells to become dysfunctional, and can even accelerate the speed at which healthy cells become senescent. Spermidine appears to reduce this chronic inflammation and may slow down one way in which cells and tissues age.
Spermidine & May delay aging
On the longevity front, the administration of spermidine has been shown to increase lifespan in a number of animal studies and prevents liver fibrosis and hepatocellular carcinoma. This also appears to be the case with a diet rich in polyamines. There is also some evidence to suggest that it improves resistance to stress and that the age-related decline of spermidine supports the onset of age-related diseases.
Lipid metabolism is a known regulator of lifespan, and dysfunctional lipid metabolism can have serious ramifications for both healthspan and lifespan. The role that spermidine plays in the process of adipogenesis, the creation of adipocytes (fat cells) from stem cells, and its ability to modify lipid profiles could suggest another way in which spermidine influences lifespan. Spermidine facilitates the differentiation of preadipocyte cells into mature adipocyte cells as part of the adipogenesis process.
Spermidine & Cancer and cardiovascular health
There is also some evidence that it might reduce the risk of cardiovascular disease. In a 2016 study, spermidine was found to turn back the aging clock and improve cardiovascular function in aged mice. At the organ level, heart structure and function were improved in the aged mice given spermidine. The same mice also saw improvements to their metabolism due to restoration of mitochondrial structure and function following spermidine supplementation.
In humans there were two population based studies (summarized in the same paper) whose data suggests that spermidine intake is linked to a reduction of all cause, cardiovascular and cancer-related mortality in humans.
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References:
https://www.lifespan.io/news/a-summary-of-spermidine/
https://spermidinelife.us/pages/what-is-spermidine