What is flurbiprofen
Flurbiprofen powder is a nonsteroidal anti-inflammatory drug mainly used to relieve pain and reduce inflammation. It belongs to the phenyl propionic acid class of NSAIDs that ease pain and inflammation by reducing the production of inflammation-related chemicals. It is clinically suitable for rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, etc. It can also be used for the symptomatic treatment of soft tissue diseases such as sprains and strains and mild and moderate pain such as dysmenorrhea, postoperative pain, and toothache. It belongs to the propionate class of NSAIDs and has similar effects to other NSAIDs, such as aspirin and ibuprofen. Flurbiprofen exerts its action by inhibiting cyclooxygenase (COX), thereby reducing the synthesis of prostaglandins. These prostaglandins are substances produced in the body that can cause pain and inflammation. Anti-inflammatory powder flurbiprofen is more and more widely used in daily life. If you need raw flurbiprofen, don't hesitate to contact Xi'an Sonwu.
What is flurbiprofen used for
Pure flurbiprofen is a nonsteroidal anti-inflammatory drug that relieves pain and reduces fever and inflammation. Its action reduces pain and inflammation by inhibiting the formation of prostaglandins, especially COX-2. COX-2 is a class of enzymes synthesizing prostaglandins, mainly in damaged and inflamed tissues. It is a critical molecule in the inflammatory response, regulating pain, inflammation, heat generation, and tissue damage. During these processes, prostaglandins produced by COX-2 induce vasodilation, platelet aggregation, inflammatory mediators release, and neurotransmission modulation.
The target of Flurbiprofen is COX-2, and it can reduce pain and inflammation by inhibiting the activity of COX-2. However, it should be noted that COX-1 is also an enzyme involved in synthesizing prostaglandins. Still, it also plays an essential protective role in normal cells, such as promoting the growth of gastric mucosa and maintaining kidney function. COX is an important enzyme that plays a crucial role in inflammatory reactions, and its catalysis can convert arachidonic acid (AA) into a series of biologically active substances. Among them, prostaglandin is a significant mediator in the inflammatory response, so the inhibition of COX can play an anti-inflammatory and analgesic role.
In addition to COX-2 inhibition, flurbiprofen also has some other pharmacological effects. For example, it can also inhibit the function of eosinophils and reduce the infiltration and excretion of inflammatory cells. In addition, flurbiprofen can also prevent thrombosis by inhibiting platelet aggregation. Although the drug's antithrombotic effect is relatively weak, flurbiprofen can reduce thrombotic complications in some specific cases, such as after heart valve replacement and aneurysm surgery.
Indications
1. (1) Prevention of aphakic cystic punctate edema after lens removal in ophthalmic surgery.
(2) Treatment of inflammation of the anterior segment of the eye after cataract and trabeculoplasty argon laser surgery.
(3) Inhibition of pupil constriction during surgery.
2. It is clinically used to inhibit miosis during inner eye surgery and postoperative anti-inflammation. Treatment of inflammation after laser trabeculoplasty and other anterior segment tissues. It also has a therapeutic effect on giant papillary conjunctivitis, anterior uveitis, and cystoid macular edema caused by contact lenses.
3. For rheumatoid arthritis.
What drugs can affect flurbiprofen
1. Combination of flurbiprofen with acenocoumarol, dicoumarol, phenprocoumon, eptifibatide, low-molecular-weight heparin, anisindione, phenindione, warfarin, etc., causing Increased risk of bleeding.
2. Caution should be exercised when flurbiprofen is combined with alendronate sodium, as both can cause gastrointestinal irritation.
3. Combined with calcium channel blockers, the risk of gastrointestinal bleeding increases.
4. Wild chamomile can increase the incidence of adverse reactions to flurbiprofen, especially gastrointestinal damage and kidney damage, because wild chamomile also has the effect of inhibiting prostaglandins.
5. When combined with ketorolac, the stimulation of the gastrointestinal tract increases, and peptic ulcer, gastrointestinal bleeding, and (or) perforation may occur in severe cases. Combined use should be prohibited.
6. When used in combination with lithium, the clearance rate of lithium decreases, and the risk of lithium poisoning increases.
7. When combined with methotrexate, the clearance rate of methotrexate decreases, the risk of poisoning increases, and adverse reactions such as leukopenia, thrombocytopenia, anemia, and toxic kidney damage may occur.
8. When combined with cyclosporine, the toxicity of the latter increases, and reactions such as renal function damage, cholestasis, and paresthesia may occur, and the mechanism of action is still unclear.
9. Combining levofloxacin, lox ofloxacin, and flurbiprofen can increase the risk of epilepsy. The possible mechanism is the inhibition of GABA, leading to central nervous system excitation.
10. When flurbiprofen is combined with aspirin, the serum concentration of flurbiprofen is reduced by about 50%, so the two should not be used together.
11. Flurbiprofen can inhibit the metabolism of sulfonylureas and increase the risk of hypoglycemia.
12. Flurbiprofen can reduce the antihypertensive effect of β-adrenoceptor blockers.
13. Because flurbiprofen can reduce renal prostaglandins production when combined with loop diuretics and thiazide diuretics, diuretics' diuretic and antihypertensive effects will be reduced.
14. When combined with potassium-sparing diuretics, the diuretic effect will be reduced, and hyperkalemia or toxic kidney damage may occur.
15. When angiotensin-converting enzyme inhibitors are combined with flurbiprofen, the antihypertensive and natriuretic effects of the former are reduced.
16. When combined with immunosuppressive drugs, flurbiprofen may cause acute renal failure, and the mechanism of action is not yet precise.
17. Some studies have pointed out that taking flurbiprofen and then using acetazolamide flurbiprofen can increase acetazolamide's plasma protein binding rate, but there is no statistical significance. Flurbiprofen also slightly increased the steady-state volume of distribution of acetazolamide (statistically significant) but had no significant effect on acetazolamide clearance, half-life, or area under the curve. Flurbiprofen is, therefore, safer than aspirin in patients receiving acetazolamide.
FAQ
During the use of this drug, please pay attention to the following:
Do not take with other NSAIDs, including aspirin, to avoid drug interactions.
Please do not take it for a long time because long-term use may cause adverse reactions in the gastrointestinal tract, liver, and kidneys.
Please do not use it during pregnancy and breastfeeding.
Before taking it, tell your doctor about your drug allergies, any prescription or over-the-counter medication you are using, and your medical history.
If you want to know a flurbiprofen manufacturer, you can contact Xi'an Sonwu.
Email: sales@sonwu.com