NMN anti-aging supplement, recently has been found a new function---to alleviate a hangover and protect liver.
1. Why can alcohol be harmful for our body?
There are three steps to breakdown and metabolize alcohol un human body:
(1) Alcohol (ethanol) will be converted into acetaldehyde under the effect of aldehyde dehydrogenase (ADH) and NAD+;
(2) Acetaldehyde will be converted into ethanoic acid under the effect of acetaldehyde dehydrogenase 2 (ALDH2) and NAD+;
(3) Ethanoic acid will enter the tricarboxylic acid cycle and convert into carbon dioxide and water.
Acetaldehyde can not only cause DNA damage, is also a cancerogen. It is also related with brain damage, immunosenescence, fracture and changes of folic acid metabolism (affecting the next generation). The main place to metabolize alcohol is liver, which will get the most harm from over-drinking. People who has normal ALDH2 gene can decompose acetaldehyde in time. However, people with ALDH deficiency cannot do it. At that time, acetaldehyde will stack in liver and will be slowly oxidized and metabolized by the oxidase P450 in the liver, causing facial flushing, rapid heartbeat, dizziness, nausea and vomiting. The worse thing is that it is very easy to harm internal organs. The most important thing is almost 30% to 50% people is ALDH deficiency.
2. How does NMN help to alleviate a hangover and protect liver?
From above, we can see that NAD+ participate every step of alcoholic metabolism. Therefore, researchers believe that it can speed up the metabolism of alicohol to increase the level of NAD+ in human body.
NAD+ +CH3CH2OH →NADH+H++CH3CHO
NAD+ +CH3CHO+H2O →NADH+H++CH3COOH
NMN supplement can rapidly enhance the level of NAD+ in human body. Studies also showed that NMN can not only alleviate a hangover, but also can protect liver. NMN supplement can prevent the increase of ALT and AST induced by ethanol. ALT and AST is exact the biomarkers of liver damage. Meanwhile, studies also found that ethanol significantly changed the expression of 1778 genes, and NMN treatment could attenuate the effect of ethanol on 437 genes (about 25%).
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