Is RU58841 effective?
So far, male alopecia is still a problem in the medical world. At present, only minoxidil and finasteride can effectively treat (control) hair loss.
In addition, there is no other medicine that can be certified by an authority for the treatment of male hair loss. However, Mino and Fina are not 100% effective, which leads to many fans who still can't keep their hair after taking the medicine. In order to retain their youth and appearance, friends from all over the world have begun to turn their attention to some folk remedies that have not been proven by rigorous medical experiments, but folk rumors can effectively treat male hair loss, such as AD-4001, dutasteride, and fluoride. Tamide, flurodil, CB0301, RU58841, inoterone acetate, ZIX solution, etc. And friends who often visit YouTube and hairlosstalk forums outside the wall should often see stories about RU58841 treating hair loss.
As a master's degree in pharmaceutical sciences, as well as a pharmaceutical researcher, I will give you a good chat today about the story of RU58841. RU58841 is a non-steroidal anti-androgen, which was first developed in the 1980s by researchers looking for androgen-blocking therapies. The difference between RU58841 and other anti-androgen drugs is that RU58841 focuses on testosterone receptors, rather than trying to reduce or block the production of testosterone or DHT. RU58841 blocks the contact between dihydrotestosterone and hair follicle receptors to achieve treatment The purpose of male alopecia. RU58841 binds to the receptor site. The mechanism of Phenixiong's action is to inhibit the type II 5α reductase, thereby reducing the production of dihydrotestosterone (DHT), reversing the miniaturization of hair follicles, thereby treating hair loss. From the principle point of view, compared to finasteride, RU58841 does not activate the receptor, so it does not cause any usual downstream effects, and theoretically has fewer side effects. Modern medicine shows that antiandrogens have the potential to treat male prostate cancer, acne and male hair loss.
RU 58841, a new specific topical antiandrogen drug: a drug candidate for the treatment of acne, androgenetic alopecia and hirsutism", because RU58841 exhibits abnormally high local activity but no systemic activity, this compound has caused a lot of research The attention and research of the readers. Initially, research on RU58841 for the treatment of hair loss mainly focused on animals. <p>For example, in this experiment called "Follicle Re-growth with 5α-Reductase Inhibitor (Finasteride) or Androgen Receptor Blocker (RU58841) in the Bald Skin of Cynomolgus Monkeys" The researchers arranged 3 groups of test subjects, each with 10 monkeys, the first group was given 1 mg of finasteride per day; the second group received the same dose of placebo every day; the third group of monkeys, 4 RU58841 was given at a concentration of 5%, 3 rats were given RU58841 at a concentration of 0.5%, and the other 3 were given vehicle. The results of the test showed that the hair growth follicles increased by 88% on average in the monkeys using finasteride, and the RU (5%) increased by 103%; while the hair follicles of the monkeys using finasteride increased by 12% to the end size. , The use of RU (5%) is 26%. The 0.5% concentration of RU showed a weak effect, while the placebo had no effect at all. Two groups of test subjects using finasteride and RU have observed hair regrowth to varying degrees. After only 2 months of treatment, RU58841 at a concentration of 5% induced the greatest growth. In addition, after 3 months of discontinuation, in the monkeys using 5% concentration of RU58841, 2 cases of RU and metabolites (10-20 ng/ml) were detected in the plasma, and 1 case was detected at 6 months . During the medication, the serum DHT of the monkeys using finasteride was reduced by about 70%, while the monkeys using RU had no significant change. There are many similar experiments based on animal models, and you can find them in some foreign literature. These experiments are similar, if you can use a simple sentence to summarize it: we used RU58841 on animals and found that it has a better effect in treating hair loss! The subjects of the above experiments were all animals, until a company obtained the rights to RU58841 and changed its name to PSK-3841, and carried out research on the treatment of androgenetic alopecia and acne in humans with RU58841. The company conducted Phase 1 and Phase 2 human clinical trials. A total of 30 people participated in the phase 1 clinical trial, and each person applied topically 5% RU58841 solution twice a day. The experiment time was 4 weeks for the phase 1 clinical trial. The next phase 2 clinical trial was a double-blind multi-center randomized trial with a total of 120 participants. Apply 5% and 2.5% RU58841 solution locally once a day for 6 months. After the end of the second phase of the experiment, the company issued the following statement: It got a very positive conclusion: Compared with finasteride, after six months of treatment with PSK3481, the effect is similar to or better than that of finasteride. it is good!