MK 777 Powder

What Is MK777

MK 777 powder, also known as acetamoren powder, is a novel non-peptide growth hormone secretagogue (GHSR agonist) and an optimized derivative of MK-677 (ibutamoren). It mimics the effects of ghrelin, binding to the growth hormone receptor (GHS-R1a), thereby stimulating the secretion of growth hormone (GH) and insulin-like growth factor-1 (IGF-1). MK-777 is an orally active small molecule with a chemical formula of C28H40N6O5S, a molecular weight of 558.68, and a CAS number of 950841-87-9. Compared to MK-677, MK-777 exhibits improved receptor affinity and selectivity, resulting in a more effective boost in GH secretion while reducing side effects such as increased appetite and cortisol interference. MK-777 exhibits excellent metabolic and thermal stability, and has demonstrated potential in experimental studies to promote muscle growth, improve bone density, aid in anti-aging, and enhance recovery from exercise. If you need MK 777, Xi'an Sonwu can supply it. Xi'an Sonwu is looking forward to hearing from you.

HPLC Of MK 777

MK 777 For Sale

Xi'an Sonwu Biotech Co., Ltd. has rich experience in global trade and the health industry. Insisting on faith-based and quality-first principles is our company's guiding principle. We strictly control product quality, which means our selection process begins with raw materials. Additionally, we handle every detail and minimize costs to the maximum, allowing our customers to obtain cost-effective products. Based on this, customers have provided a lot of positive feedback about our products. So look for Xi'an Sonwu Biotech Co., Ltd. when buying MK 777.

Xi'an Sonwu ensures product quality and can provide samples upon request. Here is the quantity.

Customers' Good Comment

OEM Service

Xi'an Sonwu can supply high-quality MK 777 powder, its capsule, and liquid.

Customers can customise the capsules they want. The items below can be supplied.

Customised capsule shells (size, colour, material)

Customized bottles(size, color, material, style)

Customized packaging(vacuum foil packaging, box, drum)

Customized label(paint film, matte film, optical mask)

Mk 777 benefits

Here are the potential benefits based on current lab data and early research:

1. Higher Growth Hormone & IGF-1 Boost

Strong binding to the ghrelin receptor (GHS-R1a) triggers the pituitary to release GH.

IGF-1 levels may remain elevated for 18–22 hours, supporting tissue repair and growth.

2. Muscle Growth & Preservation

Promotes lean muscle mass development.

May help reduce muscle wasting during aging, injury recovery, or calorie restriction.

3. Bone Strength & Healing

Stimulates bone remodeling, potentially aiding in fracture healing and preventing osteoporosis.

4. Improved Recovery & Sleep

Similar to MK-677, may increase REM sleep quality.

Faster post-workout recovery and better joint/tendon repair.

5. Less Hunger Increase vs. MK-677

Reported to cause ~68% less hunger stimulation, making it easier to manage diet.

6. Possible Cognitive & Neuroprotective Support

Ghrelin receptor activation has been linked to memory improvement and neuroprotection in early studies.

7. Lower Impact on Cortisol & Blood Sugar

Early data suggest minimal interference with stress hormones and glucose metabolism compared to MK-677.

MK-677 VS MK-777

Here's a side-by-side comparison of MK-677 (Ibutamoren) and MK-777 (Acetamoren) based on published data and vendor-reported research results:

MK-677 vs MK-777 Comparison

Key Takeaways

MK-777 is essentially a refined version of MK-677, aiming for longer IGF-1 elevation, less appetite spike, and reduced cortisol/blood sugar disruption.

MK-677 has actual human trial data, MK-777 does not yet - so MK-777's advantages are mostly predicted from lab research.

If the lab data holds true in humans, MK-777 could be more user-friendly for those who found MK-677's hunger increase and water retention problematic.

Mechanism Of Action Of MK 777

MK-777 (Acetamoren) works through a mechanism very similar to MK-677, but with some chemical tweaks that make it more selective and longer-lasting.

Here's the step-by-step mechanism of action:

1. Ghrelin Receptor Agonism (GHS-R1a Activation)

MK-777 binds to the growth hormone secretagogue receptor type 1a (GHS-R1a) in the hypothalamus and pituitary gland.

This receptor is the same one activated by ghrelin, the natural "hunger hormone."

2. Hypothalamic Signaling

Receptor activation stimulates hypothalamic neurons to release growth hormone–releasing hormone (GHRH).

GHRH signals the anterior pituitary to release growth hormone (GH) into the bloodstream.

3. Increased Growth Hormone (GH) Release

GH levels rise in a pulsatile but elevated fashion.

MK-777's design allows for 8–10 hours of active receptor engagement, leading to a sustained GH pulse pattern.

4. Hepatic IGF-1 Production

Elevated GH stimulates the liver (and other tissues) to produce insulin-like growth factor-1 (IGF-1).

IGF-1 remains elevated for 18–22 hours post-dose with MK-777 - longer than with MK-677.

5. Anabolic & Metabolic Effects of IGF-1

Muscle: Stimulates protein synthesis and satellite cell activation → muscle growth & repair.

Bone: Promotes osteoblast activity → increased bone density.

Skin/Connective Tissue: Increases collagen synthesis.

Brain: May enhance neurogenesis and synaptic plasticity.

6. Reduced Ghrelin-Linked Side Effects

Unlike MK-677, MK-777's structure causes less hypothalamic hunger stimulation (~68% lower).

Also appears to cause less activation of pathways linked to cortisol and glucose dysregulation.

7. Summary Flow:

MK-777 → GHS-R1a activation → ↑ GHRH → ↑ GH → ↑ IGF-1 → anabolic, metabolic, and regenerative effects

MK 777 Side Effect

Here are the possible side effects of MK-777 (Acetamoren) based on its similarity to MK-677 and limited preclinical data:

Commonly Suspected Side Effects

(based on ghrelin receptor agonists in general)

1. Mild Water Retention / Edema

Likely less than MK-677, but still possible due to increased GH → IGF-1 activity.

2. Joint Pain or Stiffness

A result of rapid fluid shifts or collagen remodeling.

3. Numbness / Tingling in Hands or Feet

Similar to "carpal tunnel–like" symptoms sometimes seen with higher GH levels.

4. Fatigue or Lethargy

Some users may feel temporarily tired after the GH spike.

5. Insulin Sensitivity Changes

MK-777 is reported to have less impact than MK-677, but glucose regulation should still be monitored in theory.

Potential but Less Likely Risks

Increased Blood Pressure (from mild fluid retention)

Headaches (due to IGF-1 changes)

Hormonal Imbalance if misused long-term

Unknowns

No completed human trials → side effect frequency and severity are not fully established.

Most data come from animal studies or extrapolation from MK-677.

Factory

1. Xi'an Sonwu has a factory with sufficient stock. In addition, Xi'an Sonwu has a clean and tidy production department with advanced equipment. Under the company's leadership, researchers continue to develop new products to meet customers' needs.

2. Xi'an Sonwu has advanced testing equipment and professional testing personnel, all of which show that Xi'an Sonwu aims to provide accurate and effective data and good service.

Certificate

Packing

Logistics Update

In addition to guaranteeing product quality, the other most vital thing is that clients receive the goods smoothly. So, Xi'an Sonwu supplies all kinds of couriers according to different needs.

FAQ

1. How to inquire?

We can be reached by phone, email, or social media.

2. How do you guarantee the quality of products?

Each batch must be tested, and a COA can be supplied to customers. Additionally, all the products pass the test: HPLC, UV, GC, TLC, etc. We also cooperate with third parties, such as SGS.

3. How do you pack and store?

Pack: Use sealed export-grade drums and vacuum-sealed foil packaging, or pack the goods according to customers' needs.

Storage: Store it in a dry, cool place, away from sunlight.

If you want to know about the MK 777 powder, you can contact Xi'an Sonwu. Click the email, and then you get high-quality acetamoren powder.

Email: sales@sonwu.com

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