Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of mk 777 acetamoren powder in China. We warmly welcome yuo to wholesale bulk mk 777 acetamoren powder for sale here from our factory. Quality products and reasonable price are available.
MK777 Supplement
MK 777 acetamoren powder is a selective growth hormone secretagogue receptor (GHSR) antagonist. Its chemical name is [3-[4-(2-methylpropyl)phenyl]-N-[(1R)-1-(methylcarbamoyl)-2-phenylethyl]propionamide. This compound belongs to the phenylpropanamide class of derivatives. MK-777 acts by specifically blocking the ghrelin receptor (growth hormone secretagogue receptor type 1a). Its structure mimics some features of the natural ligand ghrelin, but it acts as an antagonist rather than an agonist. It is an optimized analog of MK-677 (ibutamole). It has enhanced binding affinity for the ghrelin receptor (GHS-R1a) and improved pharmacokinetics. Its binding affinity is reportedly 92% higher than that of MK-677, its half-life is longer (approximately 8-10 hours), and it produces sustained increases in IGF-1 levels for 18-22 hours. From a chemical stability perspective, MK-777 is a solid at room temperature, exhibiting good chemical stability. However, its solubility is low at neutral pH, posing a challenge to its formulation development. Crystal structure analysis reveals that specific spatial conformations are crucial for receptor binding, with the stereocenter (R configuration) in particular having a decisive influence on biological activity. MK-777 is an experimental growth hormone-releasing agonist currently in laboratory research. As a derivative of MK-677, it is gaining increasing interest among researchers. If you are interested in this product, just feel free to contact Xi'an Sonwu. Xi'an Sonwu can supply pure MK777, so get in touch with Xi'an Sonwu!
MK 777 Third Party testing –HPLC
Where To Buy MK777
Xi'an Sonwu Biotech Co., Ltd. Ltd. Has rich experience in global trade and the health industry. Xi'an Sonwu insists on faith-based and quality-first principles. Xi'an Sonwustrictly controls product quality, which means selection starts from raw materials. Besides, Xi'an Sonwu handles every detail and reduces costs to the maximum extent, allowing our customers to obtain a cost-effective product. Based on these, customers have provided very positive feedback on our products. So, look for Xi'an Sonwu Biotech Co., Ltd. when buying it.
Xi'an Sonwu ensures the product's quality thoroughly so that a sample can be supplied. Here is the Quantity.
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MK 777 Form |
Sample Amount |
The minimum of Quantity |
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Powder |
10g |
10g |
Customer's Good Comment
MK 677 VS MK 777
MK 777 acetamoren powder and MK-677 are two growth hormone secretion agonists (GHSR agonists) that have garnered significant attention in recent years in bodybuilding, anti-aging, and regenerative medicine research. Neither directly delivers growth hormone, but instead stimulates the body's natural secretion to increase GH (growth hormone) and IGF-1 (insulin-like growth factor-1) levels. Their mechanisms of action are similar, but they exhibit key differences in structure, efficacy, and side effects. Ibutamoren was initially developed to treat conditions such as growth hormone deficiency, muscle atrophy, and senile Osteoporosis. Acetamoren was designed as an optimized version of MK-677, enhancing its efficacy and minimizing its side effects.
Both MK-777 and MK-677 act on the GHSR, but their structures lead to distinct pharmacological effects. MK-677's indole-steroid hybrid structure makes it a potent agonist, while MK-777's phenylalanamide structure leads to antagonist activity. This structural difference is also reflected in their physicochemical properties-MK-677 has a larger molecular weight and higher lipid solubility, which may affect their pharmacokinetic profiles. MK-777 and MK-677 target the same receptor, but their effects on downstream signaling pathways are opposed. MK-677 activates signaling pathways including the Gq-PLC-IP3/DAG pathway, calcium-dependent signaling, the MAPK/ERK pathway, and activation of the GH-IGF-1 axis. MK-777, on the other hand, inhibits all of these pathways. Interestingly, the two compounds have comparable receptor binding affinities but elicit diametrically opposite functional outcomes, highlighting the complexity of G protein-coupled receptor (GPCR) ligand selectivity (biased signaling).
In research applications, although MK-777 and MK-677 target the same receptor system, their potential applications are nearly opposite. As an agonist, MK-677 is primarily explored for anabolic stimuli (muscle growth, trauma recovery, etc.); as an antagonist, MK-777 is more focused on appetite suppression and potential anti-pathological effects.
MK 777 Benefits
1. Promotes Muscle Growth and Recovery
MK-777 activates the ghrelin receptor GHSR-1a, which in turn stimulates the pituitary gland to secrete growth hormone (GH), indirectly increasing levels of IGF-1 (insulin-like growth factor-1). These two hormones play a key role in muscle synthesis and repair. IGF-1 is one of the most critical hormones for muscle growth, stimulating satellite cell proliferation and differentiation, promoting muscle fiber hypertrophy; GH enhances amino acid uptake and protein synthesis. Following a caloric deficit or intense training, GH reduces muscle protein breakdown, preserving muscle mass.
2. Increases Bone Density and Prevents Osteoporosis
Bone density refers to the mineral content of bone tissue per unit volume and is an essential indicator of bone strength and osteoporosis risk. GH and IGF-1 are key hormones for maintaining bone density. Individuals with growth hormone deficiency or low IGF-1 levels often experience decreased bone density, increased fracture risk, and Osteoporosis. For this reason, investigational drugs such as MK-677 and MK-777 have theoretical value in this area.
3. Aids Traumatic and Postoperative Recovery
Recovery after tissue damage involves three phases: inflammation, proliferation, and remodeling. GH and IGF-1 play a role in these three phases, respectively. GH enhances immune response, increases cellular metabolism, and stimulates IGF-1 secretion. IGF-1 promotes the proliferation and migration of cells in tissues such as muscle, nerves, skin, and bone, accelerating wound healing.
Factory
1. Xi'an Sonwu Biotech Co., Ltd has its factory to produce, manufacture, and store the products, so it has adequate stock. Xi'an Sonwu has a well-ordered, clean, and tidy production department. Under Xi'an Sonwu, researchers can continuously develop high-quality new products.
2. Xi'an Sonwu has strict requirements on personnel allocation from production and testing to sales. To ensure that each product is escorted, rigorous data support and after-sales service are provided.
Certificates
Packaging
Logistics
Besides guaranteeing the product, the other most crucial thing is that customers can receive the goods smoothly. So, Xi'an Sonwu supplies all kinds of couriers according to different needs.
FAQ
MK-777 is a powerful tool for studying the ghrelin system, but caution is advised.
Currently limited to research use, it is not approved for human use or non-research purposes.
Suggested Research Directions
Exploring intermittent dosing regimens (to reduce the risk of long-term GH suppression).
Combination studies (e.g., with selective androgen receptor modulators).
In-depth mechanistic studies (e.g., satellite cell activation, autophagy regulation, etc.).
If you are looking for MK 777 acetamoren powder manufacturer, you can contact Xi'an Sonwu. Click the email, and you'll receive high-quality product.
Email: sales@sonwu.com
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