What Is Tadalafil
Raw tadalafil powder, also known as cialis powder, is a selective reversible inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase 5 (PDE5). When sexual stimulation leads to the local release of nitric oxide, PDE5 is inhibited by tadalafil, which increases the level of cGMP in the corpus cavernosum of the penis, which leads to smooth muscle relaxation, blood flow into the penile tissue, and erection; if there is no sexual stimulation, the drug may not work. It is mainly used to treat male erectile dysfunction (ED), benign prostatic hyperplasia (BPH) and pulmonary arterial hypertension (PAH). It is rapidly absorbed after oral administration, and the median time after taking the drug is 2 hours to reach the average maximum observed plasma concentration (cmax). The absolute bioavailability of this product after oral administration has not been determined. The absorption rate and extent of cialis are not affected by food, so this product can be taken with or without food. The time of taking the drug (morning or evening) has no clinically significant effect on the absorption rate and extent. The average distribution volume is about 63 liters, indicating that cialis is distributed into the tissue. At therapeutic concentrations, 94% of it in plasma is protein-bound. Protein binding is not affected by renal impairment. In healthy subjects, the average oral clearance of cialis is 2.5L/hr, and the average half-life is 17.5 hours. It is excreted mainly in the form of inactive metabolites, mainly in the feces (about 61% of the dose) and a small amount in the urine (about 36% of the dose). If you need tadalafil, Xi'an Sonwu can supply it. Xi'an Sonwu is looking forward to hearing from you.
Certificate Of Analysis
ITEMS |
SPECIFICATIONS |
TESTING RESULTS |
Assay |
≥99.0% |
99.42% |
Appearance |
White or almost white crystalline powder |
Conform |
Identification |
UV |
Conform |
Melting point |
302.0~303.0℃ |
302.1~30.7℃ |
Loss on drying |
≤0.5% |
0.20% |
Heavy metal |
≤10ppm |
Conform |
Special optical rotation |
[ a ]D20=+70°~+74° |
Conform |
Relative substance |
Total impurity: ≤0.5% |
0.43% |
Conclusion |
Conform with specifications |
Where To Buy Tadalafil
Xi'an Sonwu Biotech Co. Ltd. has rich experience in the global trade and the health industry. Insisting on faith-based and quality first is our company's principle. We strictly control product quality, which means selection starts from raw material. Besides, we handle every detail and reduce costs to the maximum so our customers can get cost-effective products. Based on these, customers have given a lot of good feedback about our products. So look for Xi'an Sonwu Biotech Co. Ltd. when buying tadalafil.
Xi'an Sonwu ensures product quality and can provide samples. Here is the quantity.
Tadalafil Form |
Sample Amount |
MOQ |
Powder |
100g |
100g |
Customers' Good Comment
What Is Tadalafil Used For
Tadalafil is primarily used for three main conditions:
1. Erectile Dysfunction (ED): It increases blood flow to the penis during sexual stimulation, which helps men with ED get and keep an erection. It can last up to 36 hours, making it a long-acting option for treating ED.
2. Benign Prostatic Hyperplasia (BPH): In addition, it is given to treat BPH symptoms like frequent urination, increased urgency, and trouble peeing. It functions by calming the muscles in the prostate and bladder.
3. Pulmonary Arterial Hypertension (PAH): It lessens the burden on the heart and enhances exercise capacity by relaxing blood vessels in the lungs, which aids in the treatment of PAH.
Each use involves its ability to relax smooth muscle tissue and improve blood flow in different body areas.
Does Tadalafil Have Other Benefits
Raw tadalafil powder has several potential advantages beyond treating erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and pulmonary arterial hypertension (PAH). However, these are not its primary indications:
1. Improved Exercise Tolerance: It can enhance exercise capacity, particularly in people with PAH, by improving blood flow and oxygen delivery to muscles. This benefit is mainly noted in people with specific cardiovascular or pulmonary conditions.
2. Potential for Cardiovascular Health: According to some research, cialis and other PDE5 inhibitors may protect the cardiovascular system by enhancing blood vessel lining and lowering blood pressure, among other things. However, these benefits are still being researched and are not a primary reason for prescribing the medication.
3. Raynaud's Phenomenon: According to some research, it may be able to lessen the symptoms of Raynaud's phenomenon, a disorder that causes restricted blood flow to the fingers and toes, frequently as a reaction to stress or cold. By improving circulation, it could reduce symptoms like pain and color changes in the extremities.
4. Off-Label Use for Altitude Sickness: It has been investigated as a possible treatment to prevent or lessen the symptoms of high-altitude sickness because of its capacity to widen blood vessels and enhance oxygenation; however, this use is less prevalent and not formally approved.
These additional benefits are still under investigation, and cialis is not typically prescribed for these purposes unless indicated explicitly by a healthcare professional.
What Is The Best Time To Take Tadalafil
The best time to take it depends on why you are taking it:
A. For Erectile Dysfunction (ED):
1. As Needed: It is often taken as needed, ideally half an hour or more before engaging in sexual activity. Compared to other ED drugs, its effects can last up to 36 hours, giving you more freedom. You do not need to time it as strictly around sexual activity.
Dosage: For this reason, 10 or 20 mg is a common dose, according on the patient and physician recommendations.
2. Daily Use: Regardless of when sexual activity is anticipated, it can also be taken as a daily low dose (2.5 mg to 5 mg) at the same time every day for individuals who enjoy spontaneity. This maintains a steady level of the drug in your system, making it possible to engage in sexual activity at any time.
B. For Benign Prostatic Hyperplasia (BPH):
It is typically taken once a day, with or without food, at the same time each day (usually 5 mg daily). This helps manage BPH symptoms continuously.
C. For Pulmonary Arterial Hypertension (PAH):
It is prescribed as a daily medication, and it's usually taken at the same time every day to manage PAH. The recommended dose for this condition is often 40 mg once daily, but your doctor will provide the correct dosage.
D. General Tips:
1. It can be taken with or without food.
2. If you are on a daily regimen, try to take it at the same time every day to maintain a consistent level of the drug in your system.
3. When using cialis, stay away from alcohol as it may raise your risk of experiencing negative effects like dizziness or a dip in blood pressure.
Always follow your healthcare provider's instructions on how and when to take cialis.
What To Avoid When Taking Tadalafil
When taking it, there are several things you should avoid to prevent adverse effects or interactions:
1. Nitrate Medications:
Avoid taking it with nitrates (e.g., nitroglycerin, isosorbide mononitrate, isosorbide dinitrate) commonly used for chest pain (angina). A hazardous drop in blood pressure brought on by the combination may result in fainting, a heart attack, or a stroke.
2. Excessive Alcohol:
Limit alcohol consumption when taking it. Excessive alcohol consumption may heighten the likelihood of adverse reactions such as lightheadedness, hypotension, and syncope. Additionally, alcohol may lessen the benefits of erectile dysfunction (ED) medicines.
3. Grapefruit and Grapefruit Juice:
Avoid grapefruit products. Cialis's metabolism may be hampered by grapefruit, which could result in elevated blood levels of the medication and a higher chance of negative effects.
4. Certain Other Medications:
Avoid taking it with certain other medications without your doctor's approval. These include:
Alpha-blockers (used for high blood pressure or prostate problems) – combining them can lead to an unsafe drop in blood pressure.
Some antibiotics, antifungals, and antiviral medications (clarithromycin, ketoconazole, or ritonavir) can also interact with it.
Blood pressure medications – as cialis lowers blood pressure, combining these drugs can intensify this effect.
5. Recreational Drugs (Poppers):
Avoid "poppers" (amyl nitrate or butyl nitrate). These recreational drugs have similar effects to nitrates and can dangerously lower your blood pressure when combined with it.
6. Heavy Meals:
Although cialis can be taken with or without food, avoid very heavy or fatty meals, as they may slow down the drug's absorption, delaying its effectiveness when taken as needed for erectile dysfunction.
7. Other PDE5 Inhibitors:
Do not combine it with other PDE5 inhibitors (like sildenafil/Viagra and vardenafil/Levitra). This can increase the risk of side effects without improving efficacy.
Before taking it, always check with your doctor to be sure there are no conflicts with any current medications you may be taking or medical issues you may have.
Factory
1. Xi'an Sonwu has a factory with sufficient stock. In addition, Xi'an Sonwu has a clean and tidy production department with advanced equipment. Under the company's leadership, researchers continue to develop new products to meet customers' needs.
2. Xi'an Sonwu has advanced testing equipment and professional testing personnel, all of which show that Xi'an Sonwu aims to provide accurate and effective data and good service.
Certificate
Packing
Logistics Update
In addition to guaranteeing product quality, the other most vital thing is that clients receive the goods smoothly. So, Xi'an Sonwu supplies all kinds of couriers according to different needs.
FAQ
1. How to inquire?
We can be reached by phone, email, or social media.
2. How do you guarantee the quality of products?
Each batch must be tested, and COA can be supplied to customers. Additionally, all the products pass the test: HPLC, UV, GC, TLC, etc. We cooperate with third parties as well, like SGS.
3. How do you pack and store?
Pack: Use sealed export-grade drums and vacuum-sealed foil packaging, or pack the goods according to customers' needs.
Storage: You can keep it in a dry and cool place and make it avoid sunlight.
If you want to know about the raw tadalafil powder, you can contact Xi'an Sonwu. Click the email, and then you get high-quality cialis powder.
Email: sales@sonwu.com
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