Rapamycin Powder

Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of rapamycin powder in China. We warmly welcome yuo to wholesale bulk rapamycin powder for sale here from our factory. Quality products and reasonable price are available.

Rapamycin powder, also known as AY 22989 powder or sirolimus powder, is a solid form of rapamycin used in research, pharmaceutical formulations, and sometimes as a supplement under medical supervision. It retains the same properties and mechanisms of action as other rapamycin forms. It is a macrolide compound with antifungal, immunosuppressant, and potential anti-aging properties. It was originally a product of Streptomyces hygroscopicus found on Easter Island (Rapa Nui) and gained attention for its antifungal properties. Later, it gained attention for its ability to suppress the immune system and could be used to prevent organ transplant rejection, especially kidney transplants. It functions by blocking the mammalian target of rapamycin (mTOR), an essential route for the expansion and multiplication of cells. AY 22989 and its analogs, or rapalogs, are being researched and used to treat damaged cells due to its capacity to limit cell proliferation. Research is exploring the potential of it to prevent restenosis (re-narrowing) of arteries after balloon angioplasty. Researchers are also looking into using its immunosuppressive qualities to treat autoimmune conditions including rheumatoid arthritis and lupus. It also has potential anti-aging properties and may have anti-aging effects. It has been shown to extend lifespan and improve healthspan (life span in a healthy state) in various model organisms. If you need, Xi'an Sonwu can supply rapamycin. Xi'an Sonwu is looking forward to hearing from you.

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Rapamycin For Sale Online

Xi'an Sonwu Biotech Co. Ltd. has rich experience in the global trade and the health industry. Insisting on faith-based and quality first is our company's principle. We strictly control product quality, which means selection starts from raw material. Besides, we handle every detail and reduce costs to the maximum so our customers can get cost-effective products. Based on these, customers have given a lot of good feedback about our products. So look for Xi'an Sonwu Biotech Co. Ltd. when buying rapamycin.

Xi'an Sonwu ensures product quality and can provide samples. Here is the quantity.

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Rapamycin Uses

Rapamycin powder (sirolimus) has a variety of uses in medicine and research, primarily due to its immunosuppressive, antiproliferative, and potential anti-aging properties. Here is an overview of its primary uses:

A. Medical Uses

1. Organ Transplantation

Immunosuppression: It primarily prevents organ transplant rejection, especially kidney transplants. It lessens the possibility that the body will reject the donated organ by suppressing the immune system.

2. Treatment of Diseased Cell Groups

Renal Cell Diseases: AY 22989 and its analogs (rapalogs) treat certain diseased cell groups, especially renal cell disease. It inhibits cell growth and proliferation, helping to slow disease progression.

Other Diseased Cells: Studies are ongoing to explore the efficacy of it in treating other diseased cell groups, such as breast cell disease, glioblastoma, and lymphoid disease.

3. Cardiovascular Health

Prevention of Restenosis: Rapamycin-coated stents are used in angioplasty to prevent restenosis (re-narrowing) of arteries. The drug inhibits smooth muscle cell proliferation, helping to keep arteries open.

4. Autoimmune diseases

Lupus and rheumatoid arthritis: Due to its immunosuppressive properties, it is being studied to treat autoimmune diseases such as lupus and rheumatoid arthritis.

B. Research and experimental uses

1. Anti-aging and longevity

Extending lifespan: Studies in various model organisms, such as mice and worms, have shown that it can extend lifespan and improve health. Studies are ongoing to understand its potential anti-aging effects in humans.

Age-related diseases: Researchers are looking at AY 22989's ability to postpone the onset of age-related illnesses like diabetes, cardiovascular disease, and Alzheimer's disease.

2. Neurodegenerative diseases

Alzheimer's and Parkinson's disease: Studies are exploring AY 22989's ability to prevent neurodegenerative diseases and improve cognitive function in diseases such as Alzheimer's and Parkinson's disease.

3. Metabolic disorders

Diabetes and obesity: Its effects on the mTOR pathway, which is involved in metabolism, make it a candidate for investigational treatment of metabolic disorders such as diabetes and obesity.

4. Inflammatory Diseases

Inflammatory Bowel Disease (IBD): Studies are looking into the possibility of using it to treat conditions including ulcerative colitis and Crohn's disease by reducing inflammation.

How Does Rapamycin Work

The mechanism of action of AY 22989 is to suppress the protein kinase known as mammalian target of AY 22989 (mTOR), which controls cell division, growth, survival, and metabolism. Here's a detailed look at how AY 22989 exerts its effects:

A. Mechanism of Action

1. Binding to FKBP12

Initial Interaction: It binds to an intracellular protein called FKBP12 (FK506-binding protein 12).

Complex Formation: This binding forms a complex between it and FKBP12, essential for its subsequent action.

2. Inhibition of mTOR

Targeting mTORC1: The rapamycin-FKBP12 complex specifically inhibits the mTORC1 (mTOR Complex 1), one of the two complexes that mTOR forms. One key regulator of cell growth and metabolism is mTORC1.

Blocking mTORC1 Activity: By inhibiting mTORC1, it blocks several downstream processes that mTORC1 controls, including protein synthesis, lipid synthesis, and cell cycle progression.

B. Effects of mTOR Inhibition

1. Cell Growth and Proliferation

Reduced Protein Synthesis: By suppressing the eukaryotic translation initiation factor 4E-binding protein (4E-BP1) and activating ribosomal protein S6 kinase (S6K), mTORC1 stimulates protein synthesis. Inhibition of mTORC1 by it reduces protein synthesis, which limits cell growth and proliferation.

Cell Cycle Arrest: mTORC1 activity is necessary for cell cycle progression. By inhibiting mTORC1, it can cause cell cycle arrest, particularly at the G1 phase, thereby preventing cell division.

2. Metabolism and Nutrient Sensing

Nutrient Response: mTORC1 is a crucial sensor of cellular nutrient status, including amino acids, glucose, and energy levels. Inhibition of mTORC1 by it can alter cellular metabolism and energy balance, impacting processes like autophagy (the degradation and recycling of cellular components).

3. Autophagy Induction

Enhanced Autophagy: mTORC1 typically inhibits autophagy, which helps cells survive under stress by degrading and recycling cellular components. Rapamycin-mediated inhibition of mTORC1 enhances autophagy, which can have protective effects in nutrient deprivation and stress conditions.

4. Immune Suppression

T-Cell Inhibition: mTORC1 is crucial for the activation and proliferation of T cells, a type of immune cell. By inhibiting mTORC1, it suppresses T-cell activation and proliferation, contributing to its immunosuppressive effects. This is particularly useful in preventing organ transplant rejection and treating autoimmune diseases.

5. Potential Anti-Aging Effects

Lifespan Extension: Inhibition of mTORC1 has been shown to extend lifespan in various model organisms, such as yeast, worms, flies, and mice. The exact mechanisms are still being investigated but may involve enhanced autophagy, reduced cellular senescence, and improved metabolic health.

C. Specific Pathways Affected by mTOR Inhibition

1. S6 Kinase (S6K) Pathway: mTORC1 activates S6K, which promotes protein synthesis and cell growth. Inhibition of mTORC1 by it reduces S6K activity.

2. 4E-BP1 Pathway: mTORC1 inhibits 4E-BP1, a repressor of cap-dependent translation initiation. AY 22989's inhibition of mTORC1 leads to the activation 4E-BP1, reducing protein synthesis.

3. Autophagy Pathways: mTORC1 inhibits autophagy by phosphorylating and inhibiting key autophagy-related proteins. It relieves this inhibition, promoting autophagy.

Factory

1. Xi'an Sonwu has a factory with sufficient stock. In addition, Xi'an Sonwu has a clean and tidy production department with advanced equipment. Under the company's leadership, researchers continue to develop new products to meet customers' needs.

2. Xi'an Sonwu has advanced testing equipment and professional testing personnel, all of which show that Xi'an Sonwu aims to provide accurate and effective data and good service.

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Packing

Logistics Update

In addition to guaranteeing product quality, the other most vital thing is that clients receive the goods smoothly. So, Xi'an Sonwu supplies all kinds of couriers according to different needs.

FAQ

1. How to inquire?

We can be reached by phone, email, or social media.

2. How do you guarantee the quality of products?

Each batch must be tested, and COA can be supplied to customers. Additionally, all the products pass the test: HPLC, UV, GC, TLC, etc. We cooperate with third parties as well, like SGS.

3. How do you pack and store?

Pack: Use sealed export-grade drums and vacuum-sealed foil packaging, or pack the goods according to customers' needs.

Storage: You can keep it in a dry and cool place and make it avoid sunlight.

If you want to know about the rapamycin powder, you can contact Xi'an Sonwu. Click the email, and then you get high-quality AY 22989 powder.

Email: sales@sonwu.com

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