Piperlongumine Powder

Xi'an Sonwu Biotech Co., Ltd. is one of the most professional manufacturers and suppliers of piperlongumine powder in China. We warmly welcome yuo to wholesale bulk piperlongumine powder for sale here from our factory. Quality products and reasonable price are available.

What Is The Source Of Piperlongumine

Piperlongumine powder (a piperine amide compound, also commonly known as Piplartine) is a natural small-molecule alkaloid derived from plants of the genus Piper longum (such as Piper longum). Its molecular formula is C₁₇H₁₉NO₅, and its molecular weight is approximately 317.3. Its chemical structure features substituted aromatic rings and α,β-unsaturated amide side chains, resulting in a simple overall molecular configuration but prominent functionality. The presence of conjugated double bonds and multiple electronegative oxygen atoms in the molecule confers distinct chemical reactivity and biological interactions. The α,β-unsaturated amide structure is considered the key reaction site, acting as a Michael acceptor to interact with intracellular nucleophiles; this characteristic is of great significance for its bioactivity research. Physicochemically, it typically exists as a yellow to pale yellow crystalline powder, exhibiting good chemical stability and not easily degrading under normal storage conditions. It exhibits strong lipid solubility and is readily soluble in various organic solvents, while its solubility in water is relatively limited. This characteristic is of significant reference value in formulation development and delivery system research. The rational arrangement of aromatic rings and amide groups in the molecule enables it to maintain structural stability while exhibiting good cell membrane permeability. As a small-molecule compound with a well-defined natural source and a clear structure, it has been extensively studied in natural product chemistry, medicinal chemistry, and bioactive molecule screening. It is considered a research-grade raw material with high development potential.

As one of the most popular products, this powder has received many positive customer reviews. What mostly attracts customers is high quality. In addition, Xi'an Sonwu offers highly competitive prices. If you want to learn more, just contact Xi'an Sonwu Biotech Co., Ltd.

Certificate Of Analysis

Piperlongumine Supplement

Xi'an Sonwu Biotech Co., Ltd. has rich experience in the global trade and the health industry. Xi'an Sonwu's principle is to insist on faith-based, quality-first principles. Xi'an Sonwu strictly controls product quality, which means selection starts with raw materials. Besides, Xi'an Sonwu handles every detail and minimizes costs, so customers can get cost-effective products. Based on this, customers have given very positive feedback on the products. So look for Xi'an Sonwu Biotech Co., Ltd. when buying it.

Xi'an Sonwu ultimately ensures the product's quality, enabling the samples to be supplied. Here is the quantity.

Customers' Good Comment

What Is Piperlongumine Good For

Piperlongumine powder has garnered attention primarily for its ability to regulate cellular homeostasis and balance oxidative stress, and for its selective action on abnormal cells. Extensive basic research has demonstrated that this compound exhibits significant bioregulatory activity across various cell models, offering unique advantages, particularly for studies of differential responses between abnormally proliferating and normal cells. Unlike many traditional cytotoxic molecules, it often shows a more pronounced effect on cells in abnormal metabolic states or under high stress, making it an important tool for studying diseased cells and cellular stress. Furthermore, it is widely used to explore its ability to regulate the intracellular redox environment. In various research models, it has been found to significantly affect reactive oxygen species (ROS) levels, thereby intervening in processes related to cell survival, proliferation, and apoptosis. Since oxidative stress imbalance is considered closely related to various disease states, it has demonstrated broad application value in the study of diseased cells, inflammation-related research, and the mechanisms of cellular senescence. Its natural origin and relatively well-defined mechanisms of action make it a crucial raw material for research institutions and drug development units for mechanism studies, target validation, and screening of novel candidate molecules.

From a mechanistic perspective, the biological activity of Piperlongumine primarily involves its intervention in the intracellular oxidative stress regulatory network. Studies have shown that this compound can disrupt the cellular redox balance by affecting the activity of various antioxidant defense system-related proteins, leading to an increase in reactive oxygen species (ROS) levels. In cells with abnormal metabolism or high proliferation, this increase in oxidative stress is more likely to exceed the cell's tolerance threshold, triggering downstream signaling responses, including mitochondrial dysfunction, activation of stress signaling pathways, and programmed cell death. Furthermore, the α,β-unsaturated amide structure in the Piperlongumine molecule is believed to interact covalently or semi-covalently with certain thiol-containing proteins, thereby affecting the functional state of key regulatory proteins. This structure-driven, selective-response mechanism makes it more likely to affect cell populations with weaker regulatory capabilities against oxidative stress during its action. At the signaling pathway level, it has been used to study its regulatory effects on NF-κB, MAPK, and other stress-related pathways, which are crucial for cell survival, inflammatory responses, and abnormal proliferation. Through multi-level, multi-pathway comprehensive intervention, it has developed a mechanism of action centered on oxidative stress imbalance, a key factor in its continued popularity in biomedical research. From an overall application perspective, Piperlongumine is considered a natural small molecule raw material with high research value and application potential. Its significance lies not only in its single biological effects but also in providing an important research tool for understanding cellular stress regulation, selective intervention of abnormal cells, and redox networks. As modern biomedical research gradually shifts from a single-target model to a systemic, multi-pathway regulatory strategy, natural compounds like Piperlongumine, with well-defined structures and relatively clear pathways of action, are becoming important resources for mechanistic studies and candidate molecule development.

In studies of diseased cells, Piperlongumine is frequently used to explore novel differential regulatory strategies, namely, achieving selective action by amplifying the inherent oxidative stress vulnerabilities of abnormal cells. This research approach provides a valuable reference for novel anti-cytopathic mechanisms. Simultaneously, this compound also shows broad application prospects in studies of inflammation regulation, cellular senescence, and metabolic abnormalities. Its natural origin and relatively mature chemical research foundation provide a solid basis for raw material stability, quality control, and large-scale preparation. At the level of active pharmaceutical ingredients and research-grade products, it is suitable for a range of research scenarios, including cell experiments, animal model studies, mechanism validation, and the development of structurally modified derivatives. As a parent molecule, it also provides structural templates for the design and screening of derivatives with superior pharmacokinetic properties. Therefore, it is gradually becoming one of the most promising raw materials, attracting attention in the fields of diseased cell biology, oxidative stress research, and natural product drug development, and offering value for continued in-depth research and industrial exploration.

Factory Environment

Xi'an Sonwu production factory is well-equipped, clean, and tidy, with sufficient stock. Under the company's leadership, researchers insist on developing new products. The laboratory's testing environment includes advanced testing equipment and professional testers, with a strict focus on providing valuable data for the products and ensuring customers have a quality experience.

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Logistics Record

In addition to ensuring product quality, the most vital thing is that clients receive the goods smoothly. So, Xi'an Sonwu offers a range of couriers to meet different needs.

FAQ

1. How do you contact Xi'an Sonwu Biotech Co., Ltd.?

You can contact me by email, telephone, or social media.

2. How do you ensure the quality of the product?

Xi'an Sonwu tests each batch, enabling it to supply COAs to customers. Additionally, the products pass tests for HPLC, UV, GC, and TLC. Xi'an Sonwu also cooperates with third parties, like SGS.

3. How to pack and store?

Pack: Vacuum-sealed foil packaging & Sealed export-grade drum or pack according to customers' needs.

Storage: Keep it in a dry, cool place, away from direct sunlight and heat.

If you want to buy piperlongumine powder, feel free to contact Xi'an Sonwu.

Email: sales@sonwu.com

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